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The closed-state inactivation of human N-type voltage-gated calcium channel CaV2.2 and its drug regulation mechanism
Time of Update: 2021-11-14
Voltage-gated calcium channels (Ca V ) are widely present in the human body and are closely related to a series of important physiological processes such as muscle contraction, neurotransmitter release, and pain perception .
This study reveals for the first time the structural basis of closed-state inactivation of voltage-gated calcium channels .
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The cellular mechanism of Tripterygium wilfordii against obesity
Time of Update: 2021-11-14
Williams, a researcher at the Hypothalamus Research Center of Southwestern University of Texas, said: "This new understanding of how celastrol functions at the cellular level provides more possibilities for targeted pathways that can be used in different ways.
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Chinese scholars have made progress in developing new methods of high-precision neural network force fields
Time of Update: 2021-11-14
With funding from the National Natural Science Foundation of China (approval numbers: 22073089, 22033007), the research group of Professor Bin Jiang from the University of Science and Technology of China developed a high-precision machine learning force field method based on the concept of "linear combination of atomic orbitals" in quantum chemistry This method is expected to greatly improve the accuracy of atomic simulation of complex chemical systems .
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Nature Sub-Journal: The Changing Voice of Spring
Time of Update: 2021-11-14
An international research team led by the University of East Anglia (UEA) has developed a new technology that combines world-leading citizen scientific bird monitoring data with records of individual species in the wild, reconstructing more than 200,000 people in the past 25 years Soundscapes of locations .
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Chinese scholars have made progress in artificial intelligence-assisted imaging diagnosis of new coronary pneumonia
Time of Update: 2021-11-14
In response to the above problems, the intelligent information processing team of Guangdong University of Technology based on the attention mechanism, deformable convolution theory and method, proposed an adaptive attention deep learning network AANet for "fast image detection of new coronary pneumonia" (as shown in Figure 1) .
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Chinese scholars have made new progress in the study of comprehensive myopia prevention and control in children and adolescents
Time of Update: 2021-11-14
On the basis of discovering the mechanism of reduced human choroidal blood flow and hypoxia in the sclera to induce myopia, the research team found that daily gavage of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) can significantly reduce the form deprivation of guinea pigs and mice The development of myopia and guinea pig negative lens-induced myopia (Figure 1) .
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New reagent for non-invasive imaging detection of thrombus: target fibrin to detect dangerous blood clots in the body
Time of Update: 2021-11-14
Researchers at Massachusetts General Hospital (MGH) have recently developed and tested a radiotracer [64 Cu]FBP8 that can bind to fibrin in blood clots, using positron emission tomography/PET technology to achieve non-invasive detection and Imaging thrombus in the left atrial appendage (LAA) .
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Scientists have discovered the reason why Alzheimer's disease develops in the brain-which is very different from previous views
Time of Update: 2021-11-14
"This study shows the value of using human data instead of imperfect animal models for research," said Professor Thomas Knowles, a senior co-author also from the Department of Chemistry .
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Gastroenterology: How pancreatic injury causes cancer to form
Time of Update: 2021-11-14
Researchers from Vanderbilt University and the Salk Institute for Biological Research in the United States have recently discovered through single-cell transcriptomics analysis that acinar cells in the pancreas can form new cell types to reduce damage, but they are more likely to be in the presence of mutations.
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Chinese scholars and overseas scholars have made progress in the research of acidic medium electrolytic water oxygen release catalysts
Time of Update: 2021-11-14
"Doping synergistic torsion strain effect improves the activity and stability of acidic oxygen release electrocatalysts (Torsion strained iridium oxide for efficient acidic water oxidation in proton exchange membrane electrolyzers)", on October 25, 2021 Published on "Nature Nanotechnology" .
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How do DNA particles self-assemble?
Time of Update: 2021-11-14
Brujic said: "The beauty of this process is that we can program the properties of specific materials to make them elastic or brittle, and even have self-healing ability after breaking, because bonds can be formed and broken, and they are reversible.
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Science Sub-Journal: New Antibodies
Time of Update: 2021-11-14
The antibody was determined by a team from the Duke Human Vaccine Institute (DHVI) and tested in an animal model at the University of North Carolina at Chapel Hill .
"After isolating the antibodies, the DHVI team turned to researchers at the University of North Carolina with expertise in animal coronaviruses .
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Post "Nature"!
Time of Update: 2021-11-14
In a study on mice published in the journal Nature on October 13, 2021, the team identified a subset of neurons that must exist in acupuncture and moxibustion to trigger resistance through this signaling pathway.
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Breakthrough study reveals clues to predict mortality from rare VEXAS syndrome
Time of Update: 2021-11-14
A new study published this week at the annual meeting of the American Academy of Rheumatology, ACR, shows the relationship between genotype, bone marrow failure, and the survival of patients with the rare autoinflammatory disease VEXAS syndrome, which is only in 2020.
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The first evidence that mammals regenerate kidneys
Time of Update: 2021-11-14
Their research showed that even though spiny rats suffered the same degree of tissue damage initially, they were still able to heal completely: They regenerated an apparently healthy kidney with no signs of fibrosis .
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PNAS: A new type of nerve cell found in the retina!
Time of Update: 2021-11-14
Tian said: "Based on its morphological, physiological and genetic characteristics, this type of cell does not belong to the five types of retinal neurons that were first discovered more than 100 years ago .
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Chinese scholars and overseas collaborators have made progress in bimetallic catalysis
Time of Update: 2021-11-14
The reaction has the following characteristics: (1) A new bifunctional carbene ligand was synthesized for bimetallic Ni and Al catalysis; (2) The selective olefination reaction of pyridine C3–H was completed; (3) Excellent site selection (4) The substrate has good universality and can be used for the synthesis of various simple pyridines, nitrogen-containing heterocycles and complex pyridine derivatives with biological activity (Figure 1) .
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PNAS: Sperm locates the egg by changing its swimming pattern
Time of Update: 2021-11-14
By revealing the mechanism, this research not only solves the mystery of how sperm navigate to the egg, but also has implications for human in vitro fertilization and cow reproduction, and provides new information for engineers to design miniature swimming robots .
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Nature Sub-Journal: Enhance human mental function by stimulating the brain
Time of Update: 2021-11-14
In a preliminary human study, researchers from the University of Minnesota Medical School and Massachusetts General Hospital stated that by combining artificial intelligence with targeted brain stimulation , It is possible to improve certain human brain functions related to self-control and thinking flexibility .
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From DNA molecule to super conductive electronic memory
Time of Update: 2021-11-14
"The research team used a 10-mer and a 90-mer (representing the number of nucleotides that make up the length of the molecule) of DNA to form a zipper-like structure and attach it to the gold surface or the metal of a scanning tunneling microscope.
