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On the basis of discovering the mechanism of reduced human choroidal blood flow and hypoxia in the sclera to induce myopia, the research team found that daily gavage of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) can significantly reduce the form deprivation of guinea pigs and mice The development of myopia and guinea pig negative lens-induced myopia (Figure 1)
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At the same time, intraocular injection of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) can inhibit the progression of myopia in form-deprived guinea pigs
The study shows that ω-3 PUFAs are expected to be an effective, safe and convenient drug to be used in interventions to inhibit myopia in children and adolescents, and provide a better choice for the comprehensive prevention and control of myopia in children and adolescents
Figure 1 ω-3 PUFAs inhibit form deprivation and negative lenses induce negative refractive power in myopic eyes,
Lengthening of the depth of the glass cavity and the length of the eye axis
Figure 2 ω-3 PUFAs inhibit the reduction of choroidal thickness and blood flow induced by form deprivation and negative lenses