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What are the new developments in gene editing, stem cell therapy, and cancer vaccines?
Time of Update: 2022-02-23
At the JPM conference, the company announced its Phase 2/3 clinical trial evaluating a neoantigen vaccine in combination with an immune checkpoint inhibitor as first-line maintenance therapy for newly diagnosed microsatellite stable (MSS) metastatic colorectal cancer , the first patient registration has been completed .
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Anti-cancer therapy has been upgraded with new weapons and drugs that can directly take effect on tumors!
Time of Update: 2022-02-23
The research calls this new drug SEAKER cells (Synthetic Enzyme-Armed KillER), which can act as a miniature pharmacy, and to play a role in killing tumors is a molecule called AMS found in past research, which is in A compound discovered in the development of antibiotics can safely and effectively kill cancer cells when produced only in the area of a tumor .
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Opdivo Approved for Postoperative Adjuvant Treatment of Esophageal Cancer/Gastroesophageal Junction Cancer in Taiwan, China
Time of Update: 2022-02-23
Ono Pharma recently announced that the anti-PD-1 therapy Opdivo (Opdivo, generic name: nivolumab, nivolumab) has been approved in Taiwan, China: for adjuvant therapy in patients receiving neoadjuvant concurrent chemoradiotherapy (CRT) and patients with esophageal cancer (ESC) or gastroesophageal junction cancer (GEJC) with residual pathological disease after complete resection .
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Significant improvement in dry eye symptoms New mechanism of action eye drops Phase 2 clinical results are positive
Time of Update: 2022-02-23
Recently, Aldeyra Therapeutics announced positive top-line data from a Phase 2 clinical trial of its investigational therapy reproxalap eye drops in patients with dry eye disease .
References:[1] Aldeyra Therapeutics Announces Positive Top-Line Data from Phase 2 Dry Eye Chamber Clinical Trial of Reproxalap, an Investigational New Drug, Compared to Xiidra®.
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Cell therapy GMP is really a "great" challenge
Time of Update: 2022-02-23
It can be seen from the draft released by NMPA that the scope of the GMP quality system established by cell therapy companies should be fully extended to the hospital side and the transportation side in addition to the GMP production plant, so as to form a closed-loop full-cycle quality management system for patient treatment.
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Focusing on AI and difficult-to-drug targets AstraZeneca reaches two R&D collaborations
Time of Update: 2022-02-23
Today, AstraZeneca has entered into R&D agreements with BenevolentAI and Scorpion Therapeutics, respectively, to use AI drug development platforms to accelerate the development of new drugs for systemic lupus erythematosus and heart failure, as well as to develop innovative anti-cancer therapies for difficult-to-treat transcription factors .
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Reduced bleeding rate by 85% Positive long-term results in Phase 3 clinical trial of hemophilia gene therapy
Time of Update: 2022-02-23
The trial results showed that patients who received a single gene therapy treatment had an 85% reduction in annual bleeding rate (ABR) from baseline after two years of treatment, which was superior to coagulation factor VIII prophylaxis .
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Nature sub-journal: 'kick and kill' strategy to eliminate HIV-infected cells
Time of Update: 2022-02-22
Jocelyn Kim said the strategy uses cells naturally produced by the immune system to kill infected cells that are hiding in the body and have may eradicate them .
In the new study, the researchers used SUW133 to flush HIV-infected cells out of hiding when mice were treated with antiretroviral drugs .
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How to deal with dull yellow and dull complexion?
Time of Update: 2022-02-22
As a woman, everyone wants their skin to be white and red, full of elasticity, and beautiful, so today we will talk about how to solve the problem of dark, yellow and dull complexion .
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Omicron is also "introverted" and "stealth variant" at work
Time of Update: 2022-02-22
2 variant of the new coronavirus Omicron strain were found in the country.
1% to 30% of the total number of new coronavirus samples uploaded in the country, while the BA.
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'Ice' lubricant improves osteoarthritis symptoms
Time of Update: 2022-02-22
Inspired by this surface, Chinese researchers have developed a treatment for osteoarthritis that enhances lubrication and reduces friction and inflammation in murine joints .
The researchers then injected the drug-loaded HA-MPC particles into the knee joints of rats with early-stage osteoarthritis .
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Differential expression of Afa/Dr fimbriae in multidrug-resistant Escherichia coli ST131 clones
Time of Update: 2022-02-22
check carefullyafa/dr companyThe gene complexity of ST131 suggests that regulatory regions are hotspots for the integration of is elements, and we demonstrate that is1The insertion resulted in increased Afa pili expression, highlighting the ability of the IS element to drive altered virulence at the strain level .
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The symbiotic total genome can be viewed as a solid unit for the adaptive evolution of host and gut microbes
Time of Update: 2022-02-22
The study found that under long-term artificial selection, both the host's genetic material and gut microbes have undergone adaptive changes, and there is a complex symbiotic interaction between the two .
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New link between brain cell development and mental illness
Time of Update: 2022-02-22
Scientists at Cardiff University have discovered a new link between disorders in the development of brain cells and the risk of schizophrenia and other mental illnesses .
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Unveiled behind the "1.2 million" Achilles - CAR-T cell therapy drug veil
Time of Update: 2022-02-22
The first-generation CAR consists of the variable region of the BCR and the constant region of the TCRThen, in order to put this technology into disease treatment, Eshhar cooperated with the Rosenberg laboratory to successfully construct chimeric antigen receptors for 3 different cancer targets using the single-chain antibody fragment scFv derived from antibodies.
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New coronavirus nucleic acid 20-in-1 mixed detection technical specifications released
Time of Update: 2022-02-22
Recently, the Medical Rescue Team of the Joint Prevention and Control Mechanism of the State Council issued the "Technical Specifications for 20-in-1 Mixed Collection and Detection of New Coronavirus Nucleic Acids" .
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Challenging conventional wisdom: cellular processes can be mediated by nonstructural proteins
Time of Update: 2022-02-22
Molecular simulations can provide the finest details and are then tightly coupled to experiments and instructed to provide reliable "snapshots" of the molecules under study, providing clues as to how tight interactions can also dynamically unravel genes functionally .
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Close relatives of new coronavirus variants show varying degrees of virulence
Time of Update: 2022-02-22
However, alpha and ommicron have the same furin-cleaving mutation, which in different genetic backgrounds may explain why ommicron spreads like wildfire but seems to cause less severe disease .
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Shanghai Jiaotong University's latest article: Revealing the new fate of bombesin receptor subtype 3 via extracellular vesicles
Time of Update: 2022-02-22
Further proteomic analysis found that cell-secreted extracellular vesicles were regulated by the RhoA signaling pathway, revealing a new fate of BRS-3 via extracellular vesicles, providing insights for G protein-coupled receptor (GPCR) research.
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Harnessing brain plasticity for epilepsy resilience
Time of Update: 2022-02-22
A research team led by Professor Ko Matsui of the "Super-network Brain Physiology Lab" at Tohoku University in Japan reports a stimulation modality used in laboratory animals that stimulates Patterns may develop resilience against epilepsy .
