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UBA6 Crystal Structure Publication reveals which mutations in UBA6 selectively shut down ubiquitination and FAT10 function
Time of Update: 2022-09-21
A key to the study is to identify UBA6 mutations that can cause UBA6 selective FAT10 deficiency or ubiquitin deficiency.
A key to the study is to identify UBA6 mutations that can cause UBA6 selective FAT10 deficiency or ubiquitin deficiency.
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Hailin Peng's research group and collaborators in the School of Chemistry and Molecular Engineering reported on the infrared detection of a new two-dimensional semiconductor Bi2O2Se heterojunction
Time of Update: 2022-09-21
2D semiconductor Bi2O2Se/BP van Der Waals heterojunction infrared photodetector with quantum efficiency and polarization characteristics As the "clairvoyance" for people to observe nature, infrared light detectors play an important role in infrared night vision, security reconnaissance and military remote sensing.
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Aging Cell: How interpersonal memories decay with age
Time of Update: 2022-09-21
Image credit: University of Maryland School of Medicine Figure: PDE11A memory enzyme (green) in the brains of young (left) and elderly (right) mice.
Image credit: University of Maryland School of MedicineFigure: PDE11A memory enzyme (green) in the brains of young (left) and elderly (right) mice.
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【Research Dynamics】Professor Guo Anyuan's team at the School of Life Sciences of Huazhong University of Science and Technology identified RNA features in a single extracellular vesicle for the first time
Time of Update: 2022-09-21
Figure 1 Article informationThis study proposes a high-throughput sequencing method for EVs based on the 10x Genomics platform, which explores the characteristics of the EVs transcriptome at the single EV level.
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Science: Donkeys, which were domesticated in East Africa about 7,000 years ago
Time of Update: 2022-09-21
European researchers recently reported in the journal Science that through genetic analysis of more than 200 donkeys around the world, they believe that the animal was domesticated in East Africa about 7,000 years ago.
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【Scientific research dynamics】Professor Xue Yu's team collaborated to propose a cross-omic core kinase inference algorithm
Time of Update: 2022-09-21
In this work, the researchers integrated phosphorylation group and transcriptome data to develop a cross-omics "central kinase inference" (CKI) algorithm.
In this work, the researchers integrated phosphorylation group and transcriptome data to develop a cross-omics "central kinase inference" (CKI) algorithm.
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Save the Northern White Rhino! The 10th oocyte collection yields 5 new embryos
Time of Update: 2022-09-21
The biological rescue team collected 23 oocytes from Fatu, the younger of the two remaining female northern white rhinos.
The biological rescue team collected 23 oocytes from Fatu, the younger of the two remaining female northern white rhinos.
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Science: Are you anxious? This may be because of the effects of your gut microbiome
Time of Update: 2022-09-21
According to a prospective article recently published in the journal Science by a researcher at the University of Texas Southwest, there is now growing evidence that microbes in the human gut also affect a person's neurological and emotional health.
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Intracellular in vivo imaging of novel conditionally active immunofluorescence probes
Time of Update: 2022-09-21
essayIntra Q-body: an antibody-based fluorogenic probe for intracellular proteins that allows live cell imaging and sorting Figure: (a) The double-labeled fluorescent dye in the q body of the antigen fragment binds to the target antigen and is de-quenched, thereby displaying a fluorescent signal to show the intracellular target.
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Textbooks have been updated again, with different effects of elevated carbon dioxide concentrations on plant growth
Time of Update: 2022-09-21
"We found that the increase in phytic acid levels in plants needs to be tightly controlled in order for plants to grow in a high carbon dioxide environment.
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MIT conducted an in-depth study of duplicate protein sequences
Time of Update: 2022-09-21
They found that while LCRs will vary in different proteins and species, they often have a similar role — helping proteins join larger combinations, such as nucleoli, a type of organelle found in almost all human cells.
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South China Botanical Garden made progress in the resource and environmental impact assessment of the green ammonia remote coupling system
Time of Update: 2022-09-21
As a renewable energy medium suitable for long-distance trading, chloroamine has become a new hot spot in the energy transformation strategies of many countries and multinational companies. However,
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Confirmed the effectiveness of Treg cell transplantation in the treatment of fragile bone disease
Time of Update: 2022-09-21
Quantitative increase in T regulatory cells enhances bone remodeling in osteogenesis imperfecta Mehrotra hopes to find the root cause of brittle bone disease, not just a palliative.
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Shandong University and Tsinghua University Science recently published a new paper: a new mechanism for the regulation of early human embryonic translation
Time of Update: 2022-09-21
On September 8, the team of Academician Chen Zijiang and Professor Zhao Han of the Reproductive Medicine Research Center of Shandong University, together with the team of Professor Jie Wei of Tsinghua University, discovered a new mechanism for the regulation of early human embryonic translation, and published a role of TPRXs in human zygotic genome in Science in the form of a long article entitled "Translatome and transcriptome co-profiling reveals.
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Nature Sub-Journal: A New Marker of Cancer Immunotherapy Response
Time of Update: 2022-09-21
"Understanding the T cell phenotype of CAR-T cells before and after infusion gives us insight into why patients respond or not to this potential life-saving therapy," said Catherine Wu, co-senior author of the study and a member of the Broad Institute, a professor of medicine at Harvard Medical School, and attending physician at Dana-Farber and Brigham Women's Hospital.
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Chinese scholars have made progress in the study of the mechanism of fat-brain communication mediating cognitive dysfunction in diabetes
Time of Update: 2022-09-21
Using fat grafting and a variety of exosome tracing techniques, the research team found that liver-derived extracellular vesicles (EVs) cannot mediate peripheral tissue and inter-brain communication, and adipose tissue-derived EVs are an important biological medium for forming communication between the two; In insulin-resistant and diabetic states, adipose tissue EVs carry contents miRNAs promote hippocampal synapse loss and cognitive impairment.
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iScience: A potential way to combat inherited neurological disorders
Time of Update: 2022-09-21
Image credit: Ioannou Laboratory, Department of Genetics and Genomic Sciences, Icahn School of Medicine, Mount SinaiScientists at the National Center for The Advancement of Translational Science (NCATS) at the Icahn School of Medicine in Mount Sinai, New York, and other researchers have reversed the effects of several life-threatening inherited neurodegenerative diseases— lysosomal storage disorders (LSDs) in patient cells and mice.
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Li Dan's research group and collaborators at Shanghai Jiaotong University explained the molecular mechanism of Hsp27 inhibiting pathological aggregation and toxicity of pTau in Alzheimer's disease
Time of Update: 2022-09-21
Alzheimer's disease (AD) as the most common neurodegenerative disease, the current global confirmed patients have exceeded 50 million, there is no specific drug, which seriously affects human life and
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New techniques to puzzle the hidden genome: Unknown DNA sequences may be critical to human health
Time of Update: 2022-09-21
” A large number of short RNA encoding microproteins and peptide sequences have been identified, providing new opportunities for disease research and drug development.
” A large number of short RNA encoding microproteins and peptide sequences have been identified, providing new opportunities for disease research and drug development.
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How many drinks is too much?
Time of Update: 2022-09-21
When they analyzed the samples, the researchers found that a gene called hypoxia-inducing factor 3 α subunit( Hif3a for short) was associated with changes and behaviors in the brain after alcohol exposure, such as how long the rats stayed in the maze area closed (highly anxious) or open arms (low anxiety).
