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Chinese scholars have made progress in the research of cochlear implant electroacoustic stimulation to promote the growth of auditory spiral neurons
Time of Update: 2022-10-19
x The research team used Ti3C2T x MXene to adjust the physicochemical characteristics of Matrix hydrogel, and constructed an electroacoustic stimulation three-dimensional culture system combining cochlear implant and conductive Ti3C2TxMXene-Matrigel composite hydrogel.
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Previously thought to be rigid adult brain structures, they changed after treatment
Time of Update: 2022-10-19
” the 35th European College of Neuropsychopharmacology annual conference Dr. Eric Ruhe of Laduud University Medical Center Nijmegen, the Netherlands, commented:"This means that the brain structure of patients with clinical major depression is not as fixed as we thought, and we can improve the brain structure in a short period of time, about 6 weeks or so.
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Nature sub-journal: Application of PEM-seq technology to comprehensively analyze the characteristics of Cas12 family gene editing tool enzymes
Time of Update: 2022-10-19
Screenshot of the articleOn September 24, 2022, Hu Jiazhi's research group published a research paper entitled "Comprehensive assessment of miniature CRISPR-Cas12f nucleases for gene disruption" online in Nature Communications 。 In this study, PEM-seq technology was used to compare the editing activity, off-target effects, and genome stability of various CRISPR-Cas systems in the field, focusing on the characteristics of the CRISPR-Cas12 family editing tools.
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Researchers at Boston University have discovered compounds that inhibit monkeypox virus replication!
Time of Update: 2022-10-19
"Article Identification of Small Molecules with Improved Potency against Orthopoxviruses from Vaccinia to Smallpox Monkeypox is a viral zoonotic disease (a virus transmitted from animals to humans) with symptoms similar to those of smallpox patients, but less clinically severe.
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Li's team revealed that ATF4-dependent fructose metabolism promotes the malignant progression of gliomas
Time of Update: 2022-10-19
Under conditions of energy stress (glucose deficiency), the protein kinases GCN2 and PERK selectively activate the translation of the transcription factor ATF4 by phosphorylating protein translation initiation factor eIF2α, ATF4 binds to the promoter region of SLC2A5 and ALDOB, two key genes in the fructose metabolic pathway, and activates the expression-induced fructose metabolism of these two genes, Provides an energy source for glucose-deficient GBM cells and maintains tumor malignant progression.
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Less expensive non-invasive testing is an effective alternative to colorectal cancer screening
Time of Update: 2022-10-19
。National guidelines recommend that fecal immunochemical testing (FIT) be the primary non-invasive screening modality for early-stage colorectal cancer, but a significant proportion of patients still undergo a more expensive alternative test called Cologuard?
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A new cellular process that accelerates immune cells
Time of Update: 2022-10-19
"Multiple centrosomes enhance migration and immune cell effector functions of mature dendritic cells Rush-like cells that form two centrosomes and four centrioles (green dots) upon contact with the antigen.
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The demand for irrigation water for major crops in the CPEC irrigation area improved slightly
Time of Update: 2022-10-19
TRS_Editor A{margin-top:0px;margin-bottom:15px;line-height:2;font-family:;font-size:12pt;} The China-Pakistan Economic Corridor (CPEC) is an important part of the Belt and Road Initiative, and CPEC is located in an arid-semi-arid region with scarce freshwater resources and a high proportion of agricultural water use.
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Can physical activity improve the effectiveness of chemotherapy for breast cancer?
Time of Update: 2022-10-19
Jana de Boniface, researcher of the MMK Breast Surgery Research Group, principal investigator of the trial and associate professor in the breast surgery group of the Department of Molecular Medicine and Surgery, said: "It is well known that physical activity can help patients better tolerate often demanding cancer treatments, but understanding whether and how exercise can play a role in fighting tumors and improving tumor outcomes is an emerging area of research.
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Accurately track the biodegradation process of plastics
Time of Update: 2022-10-19
Article Biodegradation of poly(butylene succinate) in soil laboratory incubations assessed by stable carbon isotope labelling Image: Electron microscopy image of the surface of the PBS film after six weeks of incubation in soil: The PBS surface shows clear signs of degradation due to fungal hyphae and bacterial colonization.
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Nature sub-journal: Mechanisms by which RNA splicing defects lead to Alzheimer's disease
Time of Update: 2022-10-19
"Previous work by Peng and others revealed a particular component of the RNA splicing mechanism, called U1 small ribonucleoprotein (snRNP), which produces aggregates in the brains of Alzheimer's patients.
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Science resurrects ancient "proteins" and reveals the "yesterday, today and tomorrow" of photosynthesis
Time of Update: 2022-10-19
Study evolution by resurrecting ancient proteins in the labTo understand this pivotal event in the evolution of Rubiscos more specifically, collaborators at the Max Planck Institute for Terrestrial Microbiology in Marburg and Nanyang Technological University in Singapore used a statistical algorithm to recreate the form of Rubiscos that existed billions of years ago before oxygen levels began to rise.
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Cell's exciting neuroprotective mechanisms combat neuroaging/degeneration
Time of Update: 2022-10-19
The researchers report that this important new finding may one day allow doctors to boost the activity of microglia to treat or protect patients with Alzheimer's, multiple sclerosis and other neurodegenerative diseases.
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A new protein that may cause Alzheimer's disease
Time of Update: 2022-10-19
"levated ganglioside GM2 activator (GM2A) in human brain tissue reduces neurite integrity and spontaneous neuronal activity There is currently no cure for Alzheimer's disease (AD), with more than 100 million people expected to fall ill worldwide by 2050.
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New research in Cell details the microbial origins of type 1 diabetes
Time of Update: 2022-10-19
About a decade ago, UO graduate student Jennifer Hampton Hill made a serendipitous discovery: a protein produced by gut bacteria that triggers insulin-producing cells to replicate.
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A new target for the treatment and prevention of osteoarthritis
Time of Update: 2022-10-19
"RORβ modulates a gene program that is protective against articular cartilage damage Scientists at the University of Florida Scripps School of Biomedical Sciences describe a specific protein that manages chondrocyte activity, a key cell type that maintains joint cartilage health.
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The discovery of the hormone family could be the key to improving crop yields
Time of Update: 2022-10-19
”essayPeptide ligand-mediated trade-off between plant growth and stress response Image: PSY receptor mutant (right) and wild type (left).
”essayPeptide ligand-mediated trade-off between plant growth and stress response Image: PSY receptor mutant (right) and wild type (left).
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The field research group has made new progress in the application of novel photothermal nanomaterials to diabetic wound healing
Time of Update: 2022-10-19
092) published online the research results of the field research group of the School of Pharmacy of Wuhan University and the Institute of Pharmacy of Zhongnan Hospital in the treatment of bacterial infections with photothermal materials 。 In this study, a supramolecular self-assembled nanomaterial based on chitosan and carburyxin photosensitizer was designed and developed, which realized effective bacterial capture and photothermal synergy antibacterial, which significantly promoted the healing of diabetic infected wounds.
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The three-dimensional atomic structure of a protein important for organ function
Time of Update: 2022-10-19
The article Cryo-EM structure of the human NKCC1 transporter reveals mechanisms of ion coupling and specificity Fig.
The article Cryo-EM structure of the human NKCC1 transporter reveals mechanisms of ion coupling and specificity Fig.
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Cell Reports can reduce neuroinflammation and dementia symptoms on a diet
Time of Update: 2022-10-19
Reference: In addition to healthy mice, the team also studied two mouse models of Alzheimer's disease, E4FAD and 3xTg. Over the course of the study, the mice were fed a simulated fasting diet twice a month for 4 to 5 days and were allowed to eat normally between FMD cycles.
