The field research group has made new progress in the application of novel photothermal nanomaterials to diabetic wound healing

Recently, Advanced Healthcare Materials (Advanced Health Materials, IF=11.
092) published online the research results
of the field research group of the School of Pharmacy of Wuhan University and the Institute of Pharmacy of Zhongnan Hospital in the treatment of bacterial infections with photothermal materials 。 In this study, a supramolecular self-assembled nanomaterial based on chitosan and carburyxin photosensitizer was designed and developed, which realized effective bacterial capture and photothermal synergy antibacterial, which significantly promoted the healing
of diabetic infected wounds.

The paper is "Self-assembled Corrole/Chitosan photothermal nanoparticles for accelerating infected diabetic wound healing.
" Chitosan photothermal nanoparticles accelerate wound healing in diabetic infection").

Yu Yunhao, a 2020 master student at the School of Pharmacy of Wuhan University, is the first author, and Yang Yingwei, professor of the School of Chemistry of Wuhan University and Jilin University, is the co-corresponding author
.
Wuhan University is the first signature and newsletter
of the paper.

Bacterial infection is one of the leading causes of human death, among which the microvascular dysfunction caused by hyperglycemia in diabetic patients leads to slow healing of diabetic wounds, which significantly increases the risk of
bacterial infection in the wound healing process.
At present, antibiotics are the most commonly used drugs
to deal with bacterial infections in clinical treatment.
However, the inappropriate use of antibiotics has led to the emergence of multidrug-resistant strains such as methicillin-resistant Staphylococcus aureus (MRSA), which severely inhibits the therapeutic effect
of antibiotics.
Therefore, the development of drug-resistant antimicrobials and strategies is essential
for the management of infectious wounds in patients with diabetes.

In view of this, the field research group used carbrole photosensitizer and chitosan as monomers, and induced the self-assembly of clickrole molecules with hydrogen bonding and π-π accumulation to form novel supramolecular photothermal nanoparticles (MCC/CS NPs) by using caction photosensitizer and chitosan as monomers to treat bacterial wound infection and promote the healing
of chronic wounds.
In this core-shell supramolecular nanosystem, the core cuckrole molecules can significantly quench molecular fluorescence emission in a highly aggregated state, produce excellent photothermal performance under 660 nm laser irradiation, and achieve photothermal conversion efficiency of up to 66.
4%, while the protonated chitosan shell has an intrinsic antibacterial effect
。 In addition, the positively charged surface of this nanoparticle can selectively target negatively charged bacteria through electrostatic interaction, producing a powerful photothermal antibacterial and inherent antibacterial synergy against E.
coli and methicillin-resistant Staphylococcus aureus under laser irradiation
.
The team further confirmed that supramolecular photothermal nanoparticles can effectively kill drug-resistant bacteria, accelerate wound healing and angiogenesis, and have good biocompatibility, showing great potential
as broad-spectrum photothermal antibacterial nanoplatforms.
In addition, the supramolecular nanosystem is simple in composition and easy to prepare, which has the promise
of further clinical translational research.

The research was supported
by the National Natural Science Foundation of China, the Basic Research Fund of the Central Universities, and the post-grant project of the Wuhan Center for Infectious Diseases and Oncology Research of the Chinese Academy of Medical Sciences.

Links to papers: https://doi.
org/10.
1002/adhm.
202201651