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The woman's sudden mental behavior was abnormal, and the culprit was actually...
Time of Update: 2021-04-18
Figure 1: With the development of the disease, patients will have different symptoms at different times (quoted from Reference 1) ①Symptoms of viral infection before 0-1 weeks; ②Psychiatric symptoms group of 1-2 weeks: delusions, hallucinations, mania, easy Irritability, speech changes, confusion, nervousness, insomnia, and epilepsy; ③weeks to months Nervous system complications: dyskinesia, autonomic dysfunction, central hypopnea, epilepsy; ④months to years long-term functional impairment : Executive dysfunction, impulse disinhibition, sleep disturbance.
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PNAS | Sun Litao et al. Discuss the pathogenic mechanism of genetic diseases of the nervous system caused by the mutation of aminoacyl tRNA synthetase gene Ⅱ
Time of Update: 2021-04-18
Sun Litao published a review titled "Aminoacyl-tRNA synthetases in Charcot-Marie-Tooth disease: a gain or a loss?" in the Journal of Neurochemistry [1], systematically expounding that gene mutations in aaRS family members cause The research progress of CMT disease, and the potential treatment of such diseases are discussed, in order to achieve precise treatment of such complex diseases (for details, see BioArt report: Non-classical function of a classic enzyme).
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Bluebird gene therapy has shown results in the treatment of childhood encephalopathy | Yimai Meng broke the news
Time of Update: 2021-04-18
Lentiviral gene therapy is recognized by the FDA as an advanced therapy for regenerative medicineThe Biopharmaceutical Innovation Technology Conference (BPIT) will be kicked off in Shanghai from April 9th to 10th, 2021.
Participants who successfully registered for the Shanghai 2021 BPIT conference will receive a limited edition of "CAR-T Cell Therapy Industry Research Report" 2021.
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Restlessness or immobility, are all "nerves" to blame?
Time of Update: 2021-04-18
1 day ago, she had speech confusion, and the answer was not what was asked and the behavior was abnormal, so she came to our hospital for treatment, perfected related examinations and admitted to the ward with "mental disorder pending investigation".
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The EEG operation specifications are still unclear?
Time of Update: 2021-04-18
In view of the fact that the interpretation of EEG is usually affected by the number of electrodes, lead arrangement and monitoring quality, Shanghai experts in this field have reached the following consensus on the technical standards and operating specifications of clinical EEG for reference.
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Clinical manifestations of distal intracranial posterior circulation syndrome|Knowledge Card
Time of Update: 2021-04-18
This article continues to organize the clinical manifestations of the distal intracranial circulation syndrome, see Table 1.
Table 1 Distal intracranial posterior circulation syndrome Yimaitong compiled from: Posterior circulation ischaemic stroke-a review part I: anatomy, aetiology and clinical presentations.
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There are more and more Parkinson's disease patients around?
Time of Update: 2021-04-18
Professor Liu Yiming said: "In the past, people always thought that trembling of the hands of the elderly was not considered a disease, but in recent years, the number of elderly patients in outpatient clinics has obviously increased.
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[Cell Reports] The brain is still a child, but the hair is already bald...how much do you know about the maturation process of the brain?
Time of Update: 2021-04-18
This article is converted Medicine original, reproduced please indicate the source Author: chen Introduction: Recently, the University of North Carolina School of Medicine, first identified microRNA-29 CH- methylation is an important regulatory factor, and explains why the methyl CH- It is important for normal brain maturation to limit the transformation to a critical period.
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Science Review | Understanding neurodevelopment by comparing circuit construction strategies of the visual and auditory systems
Time of Update: 2021-04-18
Combining examples of visual and auditory systems, linking many mechanisms found in the entire nervous system to establish synaptic specificity, and together emphasizes the study of how the interaction between fate determination, activity, and synapse formation produces circuits with different structures value.
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The 2021 version of the Chinese Restless Leg Syndrome Treatment Guidelines is released, and the treatment points are first to see!
Time of Update: 2021-04-18
➤In patients with serum ferritin <300μg/L and transferrin saturation <45%, 1000mg carboxymaltose iron is effective for the treatment of moderate to severe RLS [1A].
➤It is recommended that gabapentin-enakabi be used for RLS patients with sensory symptoms, and it is also effective for difficulty falling asleep and other insomnia symptoms [expert consensus].
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Numbness in arms and legs?
Time of Update: 2021-04-18
Out of suspicion of neurosarcoidosis, the patient underwent an enhanced CT examination of the chest, and the results showed bilateral hilar and mediastinal calcified lymph nodes and peripheral pulmonary nodules, consistent with pulmonary sarcoidosis.
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New use of old medicine: Can this medicine for treating leukemia improve cognitive function?
Time of Update: 2021-04-18
Main findings: ➤Saggrastim treatment is expected to change the innate immune system markers, and there are no serious drug-related adverse events or amyloid-related imaging abnormalities.
Potter believes that short-term sargramostim treatment increases the determination of innate immune cells and cytokines in patients with mild to moderate AD, and its safety and tolerance Good sex.
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4 stroke cases, analyze the details of the major guides, worthy of collection
Time of Update: 2021-04-18
25 mg/kg, the highest dose is 25 mg) Option C Immediately take mechanical thrombectomy (MT) Option D Give 300 mg aspirin rectal suppository and send to the stroke ward Case 280-year-old female patient, normal body function before the onset of stroke , Sent to the hospital for acute stroke preparation at 8:30 in the morning.
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Cerebral Cortex: Mother's childhood experiences and depression affect children's brain function network development
Time of Update: 2021-04-17
The results found that the functional connection of offspring children's language network and sensory motor network, frontal lobe network and attention network is related to the mother's bad experience, and interacts with gender and age.
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Neurology: After a stroke, people diagnosed with atrial fibrillation are at higher risk of death
Time of Update: 2021-04-17
Compared with those who can maintain sinus rhythm after stroke, patients with AFDAS have a higher or similar risk of recurrence of stroke or death; however, these studies are limited by little understanding of anticoagulant or antiplatelet use, and atrial fibrillation The assessment is often limited to the initial hospitalization of stroke, and only one year of follow-up time.
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Nature: Gene therapy brings dawn to incurable brain diseases
Time of Update: 2021-04-17
The results of a phase I/II clinical trial published in 2019 showed that tominersen reduced the concentration of huntingtin mutants in cerebrospinal fluid without causing any serious side effects.
The research team injected ASO drugs into the brains of mice that lost neurons in Parkinson's disease.
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Lancet: Levetiracetam vs. Valproate as the first-line treatment for idiopathic generalized or intractable epilepsy
Time of Update: 2021-04-17
Studies believe that for newly diagnosed patients with idiopathic generalized or intractable epilepsy, levetiracetam is inferior to sodium valproate in terms of therapeutic effect and cost-effectiveness .
For newly diagnosed patients with idiopathic generalized or intractable epilepsy, levetiracetam is inferior to valproate in terms of therapeutic effect and cost-effectiveness.
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Welcome to join Metz Scientific Research Mutual Aid Group | Three people, there must be my teacher
Time of Update: 2021-04-17
Metz Medical has established a scientific research mutual aid group covering 30 departments including oncology, cardiovascular, respiratory, digestion, and neurology.
Members of the group can exchange cases in real time, share journal submissions and national natural reporting experience, discuss clinical research progress, and ask peers.
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Lancet Sub-Journal: Iron metabolism and myelin changes in different brain areas may be able to predict chorea 20 years in advance
Time of Update: 2021-04-17
HealthdirectHealthdirectNot long ago, Branduff McAllister and others from Cardiff University in the United Kingdom published a study in the journal Neurology and found that as the age of onset increases, the initial manifestations of HD are more and more likely to be motor symptoms, and Few are psychiatric symptoms and have nothing to do with the length of the pathogenic CAG repeat.
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Lancet Neurology: Safety and effectiveness of enhanced blood pressure reduction after successful endovascular treatment of acute ischemic stroke (BP-TARGET): a multicenter, open-label, randomized controlled trial
Time of Update: 2021-04-17
There is no evidence that the intensive strategy of reducing the systolic blood pressure to 100-129mmHg in patients with acute ischemic stroke within 24-36 hours after successful endovascular treatment has any effect on reducing imaging intraparenchymal bleeding.
