Lancet Sub-Journal: Iron metabolism and myelin changes in different brain areas may be able to predict chorea 20 years in advance

Huntington's disease (HD) is a degenerative disease of the central nervous system .

Huntington's disease (HD) is a degenerative disease of the central nervous system, mainly due to the loss of neurons in the brain, leading to progressive motor abnormalities, cognitive decline and eventually death.

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Not long ago, Branduff McAllister and others from Cardiff University in the United Kingdom published a study in the journal Neurology and found that as the age of onset increases, the initial manifestations of HD are more and more likely to be motor symptoms, and Few are psychiatric symptoms and have nothing to do with the length of the pathogenic CAG repeat.

Not long ago, Branduff McAllister and others from Cardiff University in the United Kingdom published a study in the journal Neurology and found that as the age of onset increases, as the age of onset increases, as the age of onset increases, The initial manifestations of HD are more and more likely to be motor symptoms, and less psychiatric symptoms, and have nothing to do with the length of the pathogenic CAG repeat.

Brain atrophy occurs 15 years before symptoms appear, and brain atrophy occurs 15 years before symptoms appear.

Both autopsy studies and HD mouse models have shown that cell death, demyelination, and iron accumulation are important in the pathogenesis of HD, but the exact timing and interaction between these processes and their impact on symptomatology are unclear.

Both autopsy studies and HD mouse models indicate that cell death, demyelination, and iron accumulation are important in the pathogenesis of HD.

Experts predict pathological process HD in many years before symptoms began Experts predict pathological processes in HD for many years before symptoms began Lancet

Researchers use new imaging techniques to determine whether changes in the macro and micro structure of the entire brain can be detected in the same population.

The relationship between two groups of MPM and NfL in cerebrospinal fluid

The relationship between two groups of MPM and NfL in cerebrospinal fluid

In addition to assessing the group differences between PreHD and the control group; the correlation study between all imaging indicators and disease burden and cerebrospinal fluid neurofilament (NfL) was also carried out.

The results showed that compared with the control group, R1 and R2* in the putamen, globus pallidus, and outer membrane of PreHD participants increased significantly, suggesting increased iron deposition.

Compared with the control group, in the putamen, globus pallidus, and outer envelope of PreHD participants, R1 and R2* increased significantly, suggesting increased iron deposition.

In the MPM data, a significant result of comparison between groups.

In the MPM data, a significant result of comparison between groups.

Increased iron deposition in the subcortical structure and surrounding white matter is characteristic of very early PreHD.

The iron and myelin changes in the subcortical and cortical brain areas can change 20 years before the onset of Huntington's disease.

references:

Altered iron and myelin in premanifest Huntington's Disease more than 20 years before clinical onset: Evidence from the cross-sectional HD Young Adult Study.

Altered iron and myelin in premanifest Huntington's Disease more than 20 years before clinical onset: Evidence from the cross-sectional HD Young Adult Study.
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