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The impermanence of soldiers——Professor Chen Xiaochun talks about the real application of Memantine in the field of neurological diseases
Time of Update: 2021-04-18
A randomized, double-blind, parallel group, placebo-controlled study showed that memantine can significantly improve the cognition of patients with epilepsy (see Figure 1)12.
5. Summarize the clinical research applications of memantine in the neurological field, including dementia, epilepsy, migraine and WBRT/TBI/stroke and other diseases.
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The latest research of Northwest Agricultural University: Keep the brain "youth" and delay cognitive decline, or it can be achieved by restricting such amino acids
Time of Update: 2021-04-18
Recently, researchers from Northwest A&F University in my country published a study titled Methionine restriction alleviates age-associated cognitive decline via fibroblast growth factor 21 in "Redox Biology".
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Nature: "Worthy" motor development, can't be turned off by nature?
Time of Update: 2021-04-18
In summary, this article reveals that astrocytes regulate the microtubule structure of dendrites through Nlg 2-Nrx-1 signals, so as to efficiently close the critical period of motor nerve circuit development during a specific period and maintain normal motor functions.
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Sleep disturbance affects learning and memory, promotes Alzheimer's disease, and participates in the formation of glioma.
Time of Update: 2021-04-18
Stroke ischemic disease causes high inflammation in the body, and sleep deprivation can increase the release of inflammatory factors (IL-1beta, IL-1ra, E-selectin, ICAM-1), further aggravate inflammation, and further aggravate ischemic diseases.
Sleep deprivation affects learning, causes Alzheimer's, and even participates in the formation of glioma.
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How much do you know about the treatment of advanced Parkinson's disease?
Time of Update: 2021-04-18
For the treatment of patients with Parkinson's disease in the middle and late stages, it is necessary not only to improve motor symptoms, but also to properly handle some motor complications and non-motor symptoms.
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How many people have been misunderstood by the 9 major misunderstandings of Parkinson's disease!
Time of Update: 2021-04-18
In recent years, people's awareness of the prevention and treatment of Parkinson's disease (PD) has increased compared with the past, but there are still many patients who are rushed to the hospital, not only did not delay the development of the disease, but accelerated the deterioration.
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Do you dare to "buy drunk"?
Time of Update: 2021-04-18
Through a variety of experiments and animal studies, pathological changes related to the hangover state have been identified, including inflammatory response, neurotransmitter, receptor changes, mitochondrial dysfunction, and alcohol metabolites.
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"Collector's Edition" review | Multiple factors affect the regulation of hypothalamus on metabolism and aging
Time of Update: 2021-04-18
Obesity, aging and related metabolic diseases have become common health problems in modern society. It is generally believed that metabolic dysfunction is caused by both internal and external enviro
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Investigation | Resting tremor, slow motion!
Time of Update: 2021-04-18
After a more thorough investigation and visit, in 2011, Professor Wang Maode led the neurosurgery function group of the First Affiliated Hospital of Xi’an Jiaotong University to establish the Northwest Parkinson’s Disease Care Center to provide patients with a series of diagnosis, treatment, rehabilitation, and nursing.
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Mechanism of itching
Time of Update: 2021-04-18
These phenomena all indicate that cysteine leukotriene receptor 2 plays a key role in causing itching and atopic dermatitis, and may become a new target for the treatment of stubborn chronic itching.
Will cysteine leukotriene receptor 2 become a new target for the treatment of chronic pruritus?
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Drug treatment of early Parkinson's disease, one table summary
Time of Update: 2021-04-18
In most patients, the first-choice anti-PD drug is compound levodopa, including late-onset PD and early-onset PD with mental decline.
2. Early PD drug selection, remember two sentences (1) For most patients, the first anti-PD drug is compound levodopa, whether it is late-onset PD or early-onset PD with mental decline.
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Less or more will not work!
Time of Update: 2021-04-18
In general, this article uses electrophysiology, CRISPR-Cas9 technology, shRNA interference, pharmacology and other means to further reveal in more detail the molecular mechanism of miR-218 regulating presynaptic function through complement C3 and mediating learning and memory.
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The sooner the "German Rehabilitation Model" is activated, the better the effect of stroke rehabilitation will be!
Time of Update: 2021-04-18
On the occasion of the 3rd anniversary of "Jita Rehabilitation" under Boehringer Ingelheim (BI), the Department of Rehabilitation Medicine of Shanghai International Medical Center, supported by Jida Rehabilitation, jointly issued the "2019-2020" The Annual Rehabilitation Clinical Achievement Report" once again verified the efficacy of the "German Rehabilitation Model" for stroke patients, and the idea that the earlier rehabilitation treatment is initiated, the better the effect of stroke rehabilitation!
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After 5 years of unresponsiveness, the last reason is...
Time of Update: 2021-04-18
The video is as follows, see video 2: Normal pressure hydrocephalus (NPH), also known as Reversible dementia: refers to the clinical manifestations of the triad of gait disorder, cognitive impairment and urinary incontinence, with progressive development of varying degrees, imaging examination with enlarged ventricles, and cerebrospinal fluid pressure measured at 70-200 mmH20 Clinical syndrome.
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Cell Metab | Skeletal muscle-derived signals can hinder brain neurodegeneration
Time of Update: 2021-04-18
This study identified Stress-induced amylase and maltose mediated signal transduction from muscles to the central nervous system, maintaining protein stability in the aging brain and retina through chaperone proteins, suggesting that myogenic signals can hinder neurodegeneration in the aging process change.
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Why do you whistle when you see a girl?
Time of Update: 2021-04-18
After light-activated LPOA-ESR neurons induce vocalization behavior and chemically genetically inhibited LPOA-ESR neurons, male mice will experience reduced social voice even after close contact with female mice.
After light-activated LPOA-ESR neurons, even if the female urine is not smelled, male mice will make more social sounds.
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PNAS | Sun Litao et al. Discuss the pathogenic mechanism of genetic diseases of the nervous system caused by the mutation of aminoacyl tRNA synthetase gene Ⅱ
Time of Update: 2021-04-18
Sun Litao published a review titled "Aminoacyl-tRNA synthetases in Charcot-Marie-Tooth disease: a gain or a loss?" in the Journal of Neurochemistry [1], systematically expounding that gene mutations in aaRS family members cause The research progress of CMT disease, and the potential treatment of such diseases are discussed, in order to achieve precise treatment of such complex diseases (for details, see BioArt report: Non-classical function of a classic enzyme).
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The woman's sudden mental behavior was abnormal, and the culprit was actually...
Time of Update: 2021-04-18
Figure 1: With the development of the disease, patients will have different symptoms at different times (quoted from Reference 1) ①Symptoms of viral infection before 0-1 weeks; ②Psychiatric symptoms group of 1-2 weeks: delusions, hallucinations, mania, easy Irritability, speech changes, confusion, nervousness, insomnia, and epilepsy; ③weeks to months Nervous system complications: dyskinesia, autonomic dysfunction, central hypopnea, epilepsy; ④months to years long-term functional impairment : Executive dysfunction, impulse disinhibition, sleep disturbance.
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4 stroke cases, analyze the details of the major guides, worthy of collection
Time of Update: 2021-04-18
25 mg/kg, the highest dose is 25 mg) Option C Immediately take mechanical thrombectomy (MT) Option D Give 300 mg aspirin rectal suppository and send to the stroke ward Case 280-year-old female patient, normal body function before the onset of stroke , Sent to the hospital for acute stroke preparation at 8:30 in the morning.
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eLife: The coding of neurons in the posterior cingulate gyrus of rhesus monkeys for their own motor perception
Time of Update: 2021-04-18
The study used virtual reality system and extracellular electrophysiological technology in awake rhesus monkeys to explore how neurons located in the posterior cingulate gyrus region of the macaque brain encode their own information based on their own motor perception, and found the posterior cingulate gyrus subregion in this region.
