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Nature: New target for Alzheimer's disease, Nanjing University Li Liang/Zeng Ke's team reveals the mechanism of synaptic pruning inhibitory signal abnormality in Alzheimer's disease
Time of Update: 2021-04-19
On April 1, 2021, Liang Li/Zeng Ke's research group from the School of Life Sciences, Nanjing University published a research paper titled Loss of microglial SIRPα promotes synaptic pruning in preclinical models of neurodegeneration in the journal Nature Communications.
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AAV gene therapy developed by AAV Daniel James Wilson is administered to the first infant GM1 patient | Yimai Meng broke the news
Time of Update: 2021-04-19
Passage Bio has a strong background Passage Bio, inc is a clinical-stage genetic drug company dedicated to the development of conversion therapies for the treatment of rare single-gene central nervous system (CNS) diseases.
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Alzheimer's Dementia︱ A new non-human primate model of Alzheimer's disease: the rhesus monkey
Time of Update: 2021-04-19
, Science 2021; 371: eabb8255 plate making ︱ Wang Sizhen end of this articleA nonhuman primate model of early Alzheimer's disease pathologic change: Implications for disease pathogenesis.
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Is pain just a subjective feeling?
Time of Update: 2021-04-19
Pain perception involves a large number of psychological processes, including attention to the perception and source of pain, cognitive assessment of sensory meaning, and subsequent emotional, psychophysiological, and behavioral responses (Figure 1).
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The latest medical insurance catalogue is implemented, and China's first Huntington's disease drug will benefit more patients!
Time of Update: 2021-04-19
Among them, the therapeutic drug Antaitan (deuterated tetrabenazine tablets) approved in May 2020 for the treatment of chorea related to Huntington’s disease (HD) and adult tardive dyskinesia (TD) successfully entered the medical insurance list.
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Science: Challenge classics, artificial hallucinations, scientists reveal the neural mechanism of dopamine-induced hallucinations
Time of Update: 2021-04-19
Kepecs of Cold Spring Harbor Laboratory published an article in the journal Science to challenge the classics, fully replicate human hallucinations in mice, and reveal that striatal dopamine regulates this An illusion.
This indicates that ketamine induces hallucinations in mice as in humans.
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Overthrowing cognition, Chinese scholars reveal for the first time a new mechanism of alcohol metabolism
Time of Update: 2021-04-19
Recently, the team of Professor Zhang Ye from the Department of Anesthesiology and Perioperative Medicine of the Second Affiliated Hospital of Anhui Medical University and Professor Zhang Li from the Institute of Alcohol Abuse and Alcoholism of the National Institutes of Health jointly published a study on Nature Metabolism, which revealed Alcohol causes brain function and behavioral disorders.
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Scientists prove that there is an alert line in the mouse retina
Time of Update: 2021-04-19
The study screened the molecular markers of transient light-exhausted alpha retinal ganglion cells and constructed transgenic mice that can label and manipulate the cells, and found that such cells can encode the size of the approximate visual stimulus, and mediate the approximate visual stimulus trigger The instinctive defensive response of mice.
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Nat Commun | Li Liang/Zeng Ke's team reveals the mechanism of the abnormal synaptic pruning inhibitory signal in Alzheimer's disease
Time of Update: 2021-04-19
Recently, Liang Li/Zeng Ke’s group from the School of Life Sciences, Nanjing University published an article Loss of microglial SIRPα promotes synaptic pruning in preclinical models of neurodegeneration in Nature Communications, which systematically clarified the role of SIRPα signaling in microglial cells in synaptic pruning during early development.
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Cell Reports | Li Xuekun/Yi Wen/Shu Qiang team reveals the molecular mechanism of glycosylation regulating adult neurogenesis
Time of Update: 2021-04-19
In summary, this work clarifies that Ogt-mediated O-GlcNAc modification regulates the Notch signaling pathway by antagonizing Itch-mediated Notch1 ubiquitination, thereby maintaining the important mechanism of mouse adult neural stem cell homeostasis and adult neurogenesis.
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Neurobiology of Aging︱ Sleep and Rhythm Aging Variations and Pathological Variations
Time of Update: 2021-04-19
For example, Kun Hu, Peng Li and Lei Gao from Brigham and Women's Hospital and Harvard Medical School published a review article in the journal "Sleep, Static-Motion Rhythm and Ageing: the complex network of Alzheimer's disease" (Letter to the editor: Sleep, rest-activity rhythms and aging: A complex web in Alzheimer's disease?) [4].
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The latest research progress of neural stem cells (Phase 5)
Time of Update: 2021-04-19
html" target="_blank">Sci Rep: Research reveals that adult neural stem cell biomarkers doi:10.
html" target="_blank">Sci the Rep: Adult neural stem cell studies revealed biomarker bioon.
html" target="_blank">Nature: Neural progenitor cells from the central nervous system promote neurogenesis in cancer doi:10.
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Neuron | Draw and analyze the "architectural drawings" of the brain microvascular network
Time of Update: 2021-04-19
March 2, 2021, the David Kleinfeld laboratory of the Department of Physics and the Department of Neurobiology, University of California, San Diego, and the Howard Hughes Medical Institute Janelia Research Park MouseLight team (the first author is Ji Xiang, Department of Physics, University of California, San Diego) In the Neuron article "Brain microvasculature has a common topology with local differences in geometry that match metabolic load", the microvascular network of the whole brain of mice was measured, reconstructed and analyzed.
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New medicine for migraine!
Time of Update: 2021-04-19
Data from the Phase 3 ADVANCE study showed that during the 12-week treatment period, compared with placebo, all doses (10mg, 30mg, 60mg) of atogepant significantly reduced the average monthly migraine days from baseline.
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These 6 diseases may be misdiagnosed as "primary central nervous system vasculitis". How much do you know?
Time of Update: 2021-04-19
Patients with Sneddon syndrome usually do not need a brain biopsy, but when a brain biopsy is performed, the most prominent findings include non-specific vascular disease, thickening of the intima of small and medium blood vessels, and arterial thrombosis without inflammatory lesions.
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Experts comment on Nat Neurosci | Li Yulong's laboratory develops a new fluorescent probe to accurately detect the dynamic changes of serotonin in vivo
Time of Update: 2021-04-19
Ren Jing (UK MRC Molecular Biology Laboratory Research Group Leader) Li Yulong's team has developed a new genetically encoded 5-HT fluorescent probe that enables neuroscientists to accurately study 5-HT signaling pathways.
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The research results of Li Qi from the First Affiliated Hospital of Chongqing Medical University are written in the Stroke Journal in 2020 Acute Stroke Treatment Progress
Time of Update: 2021-04-19
608) The journal published the editorial progress in the treatment of intracerebral hemorrhage, which believed that the ultra-early intensive blood pressure reduction can make patients obtain more benefits and improve the prognosis, which was cited by JAMA Neurology.
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Science: Using limited DNA repair on the "knife edge", neurons will give priority to preventing aging and disease!
Time of Update: 2021-04-19
In a new study published in Science on April 2, Beijing time, a research team led by the Salk Institute of Biology in the United States found that neurons will use limited repair mechanisms on the "blade", focusing on repairing and "Hot spots" related to aging and disease, and these genomic sites are always at the forefront of repair work because they play a key role in neurological function.
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Can you avoid dementia when you are old?
Time of Update: 2021-04-19
In 2017, the American Heart Association (AHA)/American Stroke Association summarized the 7 major factors affecting brain health-"Life's Simple 7", including blood pressure control, cholesterol level control, and diabetes risk reduction , Regular exercise, healthy eating habits, weight control and no smoking.
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Sub-Journal of "Cell": Muscles are quietly protecting the brain!
Time of Update: 2021-04-19
Obviously, Amyrel is a key stress-induced muscle growth factor, which can improve the protein balance in the aging process and has a protective effect on neurodegeneration induced by pathogenic proteins.
