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    Home > Active Ingredient News > Study of Nervous System > The research results of Li Qi from the First Affiliated Hospital of Chongqing Medical University are written in the Stroke Journal in 2020 Acute Stroke Treatment Progress

    The research results of Li Qi from the First Affiliated Hospital of Chongqing Medical University are written in the Stroke Journal in 2020 Acute Stroke Treatment Progress

    • Last Update: 2021-04-19
    • Source: Internet
    • Author: User
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    Recently, Stroke (IF: 7.
    19), the official journal of the American Stroke Association, published a special report on Advances in Acute Stroke Treatment 2020, which reviewed and summarized the progress in the treatment of global cerebrovascular diseases in 2020.

    As the first author, Associate Professor Li Qi from the Department of Neurology of the First Affiliated Hospital of Chongqing Medical University, together with experts from teams such as Harvard University and Yale University, published the original research results in Annals of Neurology (IF: 9.
    037)-Ultra- in May 2020.
    Early blood pressure reduction attenuates hematoma growth and improves outcome in intracerebral hemorrhage (ultra-early blood pressure reduction can reduce hematoma enlargement and improve the prognosis of patients with cerebral hemorrhage), as one of the two important advances in the field of cerebral hemorrhage in 2020, it is written into the treatment of acute stroke in 2020 progress.

    Another cerebral hemorrhage study is the international multi-center clinical trial STOP-AUST published by foreign scholars in the journal Lancet Neurology.

    Cerebral hemorrhage is one of the diseases that seriously threaten human life and health, so far the treatment methods are very limited.

    Both the large international multicenter randomized controlled trials INTERACT-2 and ATACH-2 published in the New England Journal of Medicine NEJM showed that intensive antihypertensive therapy is not beneficial to control the expansion of hematoma or improve the poor prognosis of patients.

    However, Li Qi’s previous Lancet Neurology international multi-center clinical study showed that hematoma enlargement showed a non-linear downward trend from the onset of symptoms.
    At the same time, a model of the relationship between the frequency of hematoma growth and the time when symptoms appeared was established.
    It was found that most hematoma enlargement occurred when symptoms appeared.
    Within 2-3 hours, instead of 24 hours as traditionally believed.Li Qi was inspired by "there is a time window for intravenous thrombolysis in the treatment of cerebral infarction", and put forward the idea that there is a time window for treatment of hematoma expansion.

    Was the negative result of previous clinical studies because the treatment itself was not performed within the time window for the expansion of the hematoma, and whether it would be more beneficial if the blood pressure reduction was started very early.

    In order to confirm this idea, Li Qi came to Harvard University to repeatedly compare different blood pressure reduction programs for patients with cerebral hemorrhage, and proposed the concept of Therapeutic Time Window for anti-hematoma of cerebral hemorrhage, and found that intensive blood pressure reduction at the very early stage can reduce blood pressure.
    The risk of hematoma enlargement and the functional prognosis of patients are improved, bringing new dawn to the clinical treatment and scientific research of cerebral hemorrhage.

    After publication, the study was recommended by Nature Review Neurology (IF: 27.
    0) on the official Twitter, and was affirmed by the international authoritative stroke expert group.
    It was written into the international authoritative stroke monograph Stroke: Pathophysiology, Diagnosis, and Management 7th Edition (Elsevier 2021), and JAMA Neurology (IF: 13.
    608) The journal published the editorial progress in the treatment of intracerebral hemorrhage, which believed that the ultra-early intensive blood pressure reduction can make patients obtain more benefits and improve the prognosis, which was cited by JAMA Neurology.

    Experts from Johns Hopkins University have written the concept of Ultra-early treatment time window proposed by Li Qi into the paper on the path of diagnosis and treatment of cerebral hemorrhage from a single plan to a series.

    Li Qi was also invited to participate in the first ESO-WSO (European Stroke Society-World Stroke Society) joint meeting and introduced the experience of treating cerebral hemorrhage within the ultra-early treatment time window.

    Under the guidance of his tutor Professor Xie Peng, Li Qi has been focusing on the diagnosis, treatment and research of cerebrovascular diseases, and has made a series of progress in the field of cerebral hemorrhage, providing beneficial support for individualized treatment of cerebral hemorrhage.

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