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Stroke disease monitoring, see what the latest Chinese expert consensus says?
Time of Update: 2021-05-09
The application of electroencephalogram (EEG) monitoring to stroke patients can help determine the degree of consciousness coma and non-convulsive epileptic activities, and is used for the evaluation of brain damage (level B evidence, class IIa recommendation) .
Intracranial pressure monitoring is recommended for such patients (level B evidence, category IIa recommendation) .
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Cell|Systematic exploration of the role of molecular chaperone autophagy in neurodegenerative diseases
Time of Update: 2021-05-09
The author systematically explored the unique role of CMA in the maintenance of nerve cell homeostasis and neurodegenerative diseases through proteomics and other methods, which is different from general macroautophagy.
After molecular chaperone autophagy is inhibited, protein degradation is abnormal and neuronal function is affected.
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Why does a 7-year-old boy have sudden headaches, vomiting and confusion?
Time of Update: 2021-05-09
Recently, the clinical reasoning series of Neurology reported a case of acute headache, vomiting and confusion in a 7-year-old boy.
Further examination of multifocal stroke, sarcoma, and cardiac neoplasms requires testing for infection, coagulopathy, and malignant complications [such as tumor embolism, non-bacterial thrombotic endocarditis (NBTE)].
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Nature Sub-Journal: People who sleep less in middle age will increase the risk of dementia
Time of Update: 2021-05-09
The study analyzed the 25-year follow-up data of 7959 participants and reported that middle-aged and elderly people with long-term sleep less than 6 hours are associated with a 30% increased risk of dementia!
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What is the relationship between good or bad grades and changes in brain activity?
Time of Update: 2021-05-09
In order to answer the above questions, a research team from Princeton University in the United States used magnetic resonance imaging to examine the brain images of 24 undergraduate students studying the general part of the computer science course, and found that the neural activity of a specific area of the student's brain is correlated with their test scores.
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How to take medication for patients with epilepsy who have psychotic symptoms?
Time of Update: 2021-05-09
; on the other hand, it is necessary to consider the special characteristics of the symptoms of epilepsy patients, the interaction between antipsychotics and AED, and the possibility of increased risk of side effects.
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How does HR-NICE antiplatelet therapy go smoothly?
Time of Update: 2021-05-09
The 2014 edition of the "Guidelines for the Secondary Prevention of Ischemic Stroke and Transient Ischemic Attack in China" recommends that acute non-cardiogenic TIA or mild type with a high risk of stroke recurrence (ABCD2 score ≥ 4) within 24 hours of onset should be given as soon as possible Patients with ischemic stroke (NIHSS score ≤ 3 points) were treated with aspirin combined with clopidogrel for 21 days (Ⅰ, A).
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Cell blockbuster: Enhance neuronal autophagy, clear brain toxic proteins, reverse Alzheimer’s disease, and anti-aging
Time of Update: 2021-05-09
The research team has developed an experimental drug that can clear the tau protein by activating chaperone-mediated autophagy (CMA) in brain neurons and reverse key symptoms in a mouse model of Alzheimer's disease.
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New certification: After 24 months of Risdiplam treatment, 61% of children with type 1 SMA achieved unsupported sitting alone | AAN 2021
Time of Update: 2021-05-09
Other key outcomes include: the proportion of children sitting alone without support for ≥30 seconds, the proportion of children with a total CHOP INTEND score of ≥40, the achievement of exercise milestones assessed by HINE-2, the proportion of children who survived without permanent ventilation, Proportion of children who can swallow and feed orally, number of hospitalizations/patient year.
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Nature: Complex thinking is not unique to humans. Rats can master complex thinking through extraordinary abstraction ability
Time of Update: 2021-05-09
In the learning process, mouse prefrontal cortex neurons show different dynamics when acquiring category selectivity, and show different levels of participation in subsequent rule conversions.
They found that in the learning process, prefrontal cortex neurons showed different dynamics when acquiring category selectivity, and showed different levels of participation in subsequent rule conversions.
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Cell Stem Cell | Chinese Academy of Sciences Wu Qingfeng team reveals the origin of hypothalamic neuronal diversity
Time of Update: 2021-05-09
Cumulative evidence based on single-cell transcriptomics analysis revealed the transcriptional heterogeneity of cortical neural progenitor cells, their temporal patterns, and the differentiation trajectory of excitatory neurons and inhibitory interneurons in the developing mammalian neocortex.
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Science Sub-Journal: iPS Stem Cell Therapy Successfully Promotes the Recovery of Stroke and Dementia
Time of Update: 2021-05-09
The research team used artificially induced pluripotent stem cells (iPSC) to induce differentiation of glial cells and injected them into the brains of mouse models with symptoms of human stroke and dementia, successfully repairing their brain damage and improving memory function.
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Science: Can't see the brain's stress response? Two-color SPOTlight technology reveals a new mechanism of learning and memory
Time of Update: 2021-05-09
On April 23, 2021, the Nicole Calakos research team of the Department of Neurology of Duke University Medical Center published an article in Science and developed a two-color ISR signal reporting system SPOTlight: red when the ISR is activated, and green when the ISR is inactive.
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Cell Stem Cell︱Qingfeng Wu's laboratory reveals the law of "cascade diversification" of neurons
Time of Update: 2021-05-09
, Cell Stem Cell (2021)) Third, the researchers found after analyzing the early neuronal developmental lineages , Hypothalamic RGCs produced two clusters of intermediate precursor cells (IPC), which were defined as Ascl1+ and Neurog2+ hypothalamic IPCs (Figure 3A-B).
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A 64-year-old man with sudden headache and hemiplegia, is it a stroke or another cause?
Time of Update: 2021-05-09
★★★★★★★For a patient with an unclear diagnosis of acute headache, and in view of the hemorrhage and thrombosis, the medical staff present agreed that further craniocerebral CTV examination is very necessary because it involves the follow-up treatment.
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Experts comment on Cell Stem Cell | Wu Qingfeng's team discovers a new law of the origin of neuronal diversity
Time of Update: 2021-05-09
The study combined lineage tracking and single-cell technology to sequence and analyze the transcriptome of 43,261 developing mouse hypothalamic cells, map the dynamic development trajectory of the mouse hypothalamus, and identify radial glial cells (RGCs) , Intermediate Precursor Cells (IPCs), Newborn Neurons (Nascent Neurons) to Peptidergic Neurons (Peptidergic Neurons) Hypothalamus Developmental Tree, and proposed "cascade amplification law" to explain the neuronal diversity of complex brain regions origin.
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Effectively reduce cell damage in the hypoperfusion zone, this medicine protects the brain tissue!
Time of Update: 2021-05-09
The rats were sacrificed 6 hours later and the brain tissue calcium, sodium, potassium concentration and water content were analyzed; the second group of 6 mice served as the control group, and the animals were administrated with 200 μl of normal saline every 30 minutes within 4 hours after the ischemia model was established.
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Cell | Dopamine's "wave-like dynamics", revealing the timing and conditioning mechanism of reward behavior in the brain
Time of Update: 2021-05-09
According to the reward prediction error (RPE) hypothesis proposed by Schultz in 1997 [1], the dopamine signal reflects the deviation between the expected reward and the actual reward in reinforcement learning (RL).
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How to recognize and evaluate the early stage of acute posterior circulation ischemic stroke, these 4 scales should be known|Guideline consensus
Time of Update: 2021-05-09
A brief summary of the recommendations for early identification and evaluation of acute posterior circulation ischemic stroke.
Recommendations for early recognition and evaluation of acute posterior circulation ischemic stroke 1.
Expert consensus on early recognition and evaluation of acute posterior circulation ischemic stroke[J].
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Nature Sub-Journal: Zhou Zikai's research group collaborates to propose potential treatment strategies for immune abnormal autism
Time of Update: 2021-05-09
Recently, Zhou Zikai, a researcher at the Shanghai Mental Health Center-Shanghai Institute of Materia Medica, Chinese Academy of Sciences, collaborated with Ji Minjun, a professor at the State Key Laboratory of Reproductive Medicine and Department of Pathogenic Biology, Nanjing Medical University, to publish a research paper Rescue online on Nature Neuroscience of maternal immune activation-induced behavioral abnormalities in adult mouse offspring by pathogen-activated maternal Treg cells.
