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Nature: Complex thinking is not unique to humans. Rats can master complex thinking through extraordinary abstraction ability
Time of Update: 2021-05-09
In the learning process, mouse prefrontal cortex neurons show different dynamics when acquiring category selectivity, and show different levels of participation in subsequent rule conversions.
They found that in the learning process, prefrontal cortex neurons showed different dynamics when acquiring category selectivity, and showed different levels of participation in subsequent rule conversions.
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Nature Sub-Journal: Zhou Zikai's research group collaborates to propose potential treatment strategies for immune abnormal autism
Time of Update: 2021-05-09
Recently, Zhou Zikai, a researcher at the Shanghai Mental Health Center-Shanghai Institute of Materia Medica, Chinese Academy of Sciences, collaborated with Ji Minjun, a professor at the State Key Laboratory of Reproductive Medicine and Department of Pathogenic Biology, Nanjing Medical University, to publish a research paper Rescue online on Nature Neuroscience of maternal immune activation-induced behavioral abnormalities in adult mouse offspring by pathogen-activated maternal Treg cells.
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Cell Stem Cell︱Qingfeng Wu's laboratory reveals the law of "cascade diversification" of neurons
Time of Update: 2021-05-09
, Cell Stem Cell (2021)) Third, the researchers found after analyzing the early neuronal developmental lineages , Hypothalamic RGCs produced two clusters of intermediate precursor cells (IPC), which were defined as Ascl1+ and Neurog2+ hypothalamic IPCs (Figure 3A-B).
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Cell blockbuster: Enhance neuronal autophagy, clear brain toxic proteins, reverse Alzheimer’s disease, and anti-aging
Time of Update: 2021-05-09
The research team has developed an experimental drug that can clear the tau protein by activating chaperone-mediated autophagy (CMA) in brain neurons and reverse key symptoms in a mouse model of Alzheimer's disease.
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Cell Stem Cell | Chinese Academy of Sciences Wu Qingfeng team reveals the origin of hypothalamic neuronal diversity
Time of Update: 2021-05-09
Cumulative evidence based on single-cell transcriptomics analysis revealed the transcriptional heterogeneity of cortical neural progenitor cells, their temporal patterns, and the differentiation trajectory of excitatory neurons and inhibitory interneurons in the developing mammalian neocortex.
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A 64-year-old man with sudden headache and hemiplegia, is it a stroke or another cause?
Time of Update: 2021-05-09
★★★★★★★For a patient with an unclear diagnosis of acute headache, and in view of the hemorrhage and thrombosis, the medical staff present agreed that further craniocerebral CTV examination is very necessary because it involves the follow-up treatment.
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New certification: After 24 months of Risdiplam treatment, 61% of children with type 1 SMA achieved unsupported sitting alone | AAN 2021
Time of Update: 2021-05-09
Other key outcomes include: the proportion of children sitting alone without support for ≥30 seconds, the proportion of children with a total CHOP INTEND score of ≥40, the achievement of exercise milestones assessed by HINE-2, the proportion of children who survived without permanent ventilation, Proportion of children who can swallow and feed orally, number of hospitalizations/patient year.
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How to recognize and evaluate the early stage of acute posterior circulation ischemic stroke, these 4 scales should be known|Guideline consensus
Time of Update: 2021-05-09
A brief summary of the recommendations for early identification and evaluation of acute posterior circulation ischemic stroke.
Recommendations for early recognition and evaluation of acute posterior circulation ischemic stroke 1.
Expert consensus on early recognition and evaluation of acute posterior circulation ischemic stroke[J].
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2021 Post-stroke Cognitive Impairment Management Consensus Released, 3 Minutes to Focus | Guidelines Consensus
Time of Update: 2021-05-08
Table 1 Assessment of PSCI Risk Factors of Cognitive Impairment After Stroke The clear diagnosis of PSCI requires clinical, imaging, and neuropsychological evaluation.
Drug treatment recommendations: ➤ Cholinesterase inhibitors donepezil and rivastigmine can be used in the treatment of PSCI to improve patients' cognitive function and ability of daily living (level I recommendation, level A evidence).
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Brain: Does the language center only know the Broca area?
Time of Update: 2021-05-08
The researchers found that in the samples of patients with left frontal lobe injury, long-term speech production disorder (≥3 months after stroke) was only predicted by the degree of white matter damage just above the insula near the anterior portion of the arcuate tract, and was related to the degree of damage in the Broca area.
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Alzheimer Dementia-Are you lonely: People in middle age are more prone to dementia if they are alone for a long time
Time of Update: 2021-05-08
Akhter-Khan and others of the University of Berlin, Germany , explored the relationship between changes in personal loneliness in middle age and the risk of dementia and AD 18 years later.
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Lancet Neurology: Risk score based on imaging to predict the development of intracranial hemorrhage and ischemic stroke in patients with ischemic stroke or antithrombotic therapy after transient ischemic attack
Time of Update: 2021-05-08
For patients receiving antithrombotic therapy after ischemic stroke or transient ischemic attack, it is very important to balance the risk of recurrent ischemic stroke and intracranial hemorrhage.
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Nat Neurosci.: A new direction in the treatment of multiple sclerosis: microglia can remove toxic lipids in multiple sclerosis
Time of Update: 2021-05-08
Dong and colleagues studied the mechanisms that mediate neurodegeneration in multiple sclerosis and determined the direct role of oxidized phosphatidylcholines (OxPCs) in driving the death of central nerve cells.
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JNNP: Investigation of the application status of precision medicine in hereditary epilepsy
Time of Update: 2021-05-08
do?w=%E7%99%AB%E7%97%AB">epilepsy diseases, single case and small cohort reports document new precision medicine strategies for specific hereditary epilepsy.
This study aims to explore the current status of the application of precision medicine strategies for epilepsy diseases.
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JAMA Psychiatry: Correlation between age, antipsychotic drugs, and the severity of schizophrenia symptoms and glutamate levels
Time of Update: 2021-05-08
In order to better describe the glutamatergic dysfunction in patients with schizophrenia, some researchers conducted a large-scale analysis of individual participants’ data, studying age, antipsychotic drug exposure, diagnosis , symptom severity and function, and glutamine The relationship between 1H-MRS measurements of acid energy metabolite levels.
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PNAS: Can higher education really slow down the speed of brain aging?
Time of Update: 2021-05-08
In addition to cognitive reserve theory, education may have indirect benefits for the brain, protecting people from other risk factors of dementia, such as high blood pressure, diabetes, and cardiovascular disease.
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JAMA Neurol: Bariatric surgery is used to improve the clinical symptoms of idiopathic intracranial hypertension
Time of Update: 2021-05-08
Compared with the CWM group, patients in the bariatric surgery group had significantly lower intracranial pressure at 12 months (adjusted mean difference change -7.
7)The study believes that bariatric surgery is better than conventional weight intervention in improving the clinical symptoms and quality of life of patients with idiopathic intracranial hypertension.
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Experimental drug "CA" is expected to treat Alzheimer's disease
Time of Update: 2021-05-08
Therefore, they studied a mouse model of early Alzheimer's disease, in which brain neurons were modified to produce defective versions of the tau protein.
And in the brain neurons of the two mouse models, the drug significantly reduced the levels of tau protein and protein clumps compared with untreated mice.
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Radiology: For patients with ischemic stroke, X-ray angiography is not enough!
Time of Update: 2021-05-08
Recently, a study published in the journal Radiology evaluated the guiding role of MRI in clinical decision-making during the interventional treatment of acute ischemic stroke, and provided an imaging reference standard for the clinical development of corresponding treatment standards.
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Neurology: gradually freezing people, excessive cortex excitement may be related to the accumulation of TDP-43
Time of Update: 2021-05-08
The hyperexcitability of the cortex in patients with cognitive impairment is more prominent, manifested by the increase in short-interval intracortical promotion (SICF), excitability index (IE) and motor evoked potential (MEP) amplitude.
