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CMI(IF=22) The team of Xiaoyong Man of Zhejiang University revealed that the epidermal immune microenvironment plays an important role in the development of psoriasis
Time of Update: 2023-01-06
Original link: style="margin-right: auto;margin-left: auto;outline: 0px;width: 30px;display: inline-block;">—END—The content is [iNature]The skin acts as the first battleground for the host, as well as a physical and immune barrier, involved in defending against exogenous pathogens and physical dangers, and maintaining tissue homeostasis.
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What does the ACR/EULAR RA mitigation standard update optimize? Research Express
Time of Update: 2023-01-06
0 is more consistent with SDAI or CDAI mitigation standards Among the 2048 trial participants included in the study (1101 with early RA and 947 with confirmed RA), after six months of treatment, the response rate using Boolean 2.
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Immunity The mystery of longevity and function of anti-smallpox memory B cells in the human body
Time of Update: 2023-01-06
Overall, the researchers isolated and analyzed B5-specific MBCs from people vaccinated more than 40 years ago, and only a few clones that exhibited limited intraclone diversity, which were enriched in CD21hiCD20hi IgG+, persisted for a long time In the subpopulation of spleen B cells, NOTCH/MYC expression characteristics in the marginal region are exhibited.
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Bacterial infections cause inflammation, but give you more protection after vaccination?
Time of Update: 2023-01-06
Figure 2 Research results (Source: [1])The researchers first assessed the contribution of sociological factors (age, sex, ethnicity) and vaccine factors (vaccine platform, target pathogen, time after vaccination) to the transcriptome variance of blood samples.
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8 Cell/Nature/Science Gao Fu, He Dayi, Yuan Guoyong and other teams revealed the potential mechanism of Omicron's antibody escape and rapid spread
Time of Update: 2023-01-06
iNatureThe coronavirus disease 2019 pandemic continues to affect people around the world. The rapid development and deployment of effective vaccines, as well as monoclonal antibody therapies, from the
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Focus on the cutting-edge progress in the field of lupus, ACR2022 first day conference wonderful research report!
Time of Update: 2023-01-06
In a retrospective study of 442 patients [1], belilumab combination therapy for 12 months significantly reduced SLEDAS disease activity scores in SLE patients compared with usual care (SoC) (Figure 1), and more patients achieved treatment goals of low disease activity (LDA) or remission (Figure 2), suggesting that belimumab helps patients with SLE achieve LDA (HR).
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The Immunity TCR-Engine can be used to design synthetic TCRs with enhanced potency and specificity
Time of Update: 2023-01-06
Written by | T cells genetically modified to express TCR that recognize tumor-associated antigens are helpful for cancer immunotherapy, but usually because of the risk of cross-reactivity with off-tar
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Obstetricians tell you that pregnant women with rheumatism do this for testing and management
Time of Update: 2023-01-06
Conclusion: Through the use of a variety of clinical examinations and monitoring and treatment methods, rheumatism is no longer a contraindication to pregnancy and childbirth in such pregnant women.
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Leflunomide medication 4 major misunderstandings, have you stepped on the pit?
Time of Update: 2023-01-06
Since the vast majority of rheumatic immune diseases are chronic diseases, and many patients need to take drugs for a long time or even for life, this article organizes the drug experience of leflunomide in rheumatic immune diseases, and analyzes the four most common medication misunderstandings to improve the safety of patients.
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Does systemic lupus erythematosus affect pregnancy attempts?
Time of Update: 2023-01-06
Download the Decision Assistant App, the guide is free at any time~References:[1] 2020 Chinese guidelines for the diagnosis and treatment of systemic lupus erythematosus▼▼▼Click to read the original article to download the AppFor medical professionals onlyOn the relationship between SLE and pregnancy Systemic lupus erythematosus (SLE) is an autoimmune inflammatory connective tissue disease involving multiple organs in young women.
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Focus on the unmet clinical needs in autoimmune diseases and grow together with the field of immunity in China!
Time of Update: 2023-01-06
*For medical professionals onlyJoin hands with the big coffee, please look forward to an academic feast in the field of rheumatic immunity and skin immune diseases!Immune-mediated inflammatory disease
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Sjogren syndrome, what are the local manifestations?
Time of Update: 2023-01-06
Download the Decision Assistant App, the guide is free at any time~▼▼▼Click to read the original article to download the AppFor medical professionals onlyOpen the [Clinical Decision APP] and talk to the major diagnosis and treatment guidelines!
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2022ACR ends today Lupus nephritis has attracted much attention, and various research results have exploded, and this article will take you to unlock the most informative content!
Time of Update: 2023-01-06
For medical professionals onlyThe ACR Annual Meeting was directly on the spot, comprehensively explaining the heavy data and new explorations in the field of lupus nephritis. As an authoritative acade
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NBT's new tool reveals the immune peptideome antigen post-translational modification panorama
Time of Update: 2023-01-06
By analyzing data generated by different combinations of PTMs, including patient-derived tumor samples and cancer cell lines, the authors identified thousands of new modified HLA I-binding peptides.
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NBT's new tool reveals the immune peptideome antigen post-translational modification panorama
Time of Update: 2023-01-06
By analyzing data generated by different combinations of PTMs, including patient-derived tumor samples and cancer cell lines, the authors identified thousands of new modified HLA I-binding peptides.
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The latest paper of the 2022 Nobel Prize winner: targeting sugar molecules on the surface of cancer cells to enhance the effect of immunotherapy
Time of Update: 2023-01-06
Link to the paper: style="color: rgb(136, 136, 136);font-size: 12px;" _mstmutation="1" _istranslated="1"> open reprint Welcome to Moments and WeChat groups SourceChina Biotechnology NetworkAs we all know, the immune system is the body's defense network, with various abilities to remove abnormal cells.
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Bite! Super complete gout diagnosis and treatment strategy, please check!
Time of Update: 2023-01-06
*For medical professionals onlyIt's really full of dry goods~Gout is a crystal-associated arthropathy caused by monosodium urate (MSU) deposition in the joints and is directly associated with hyperuri
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Guangdong University of Technology ES&T: Chloropolycyclic aromatic hydrocarbons induce THP-1 macrophage immunosuppression—characterized by disorders of amino acid metabolism
Time of Update: 2023-01-06
Chlorinated PAHs induce immunosuppression in THP-1 macrophages characterized by disrupted amino acid metabolismFirst author: Li XinyanCorresponding author: Luan TiangangAuthor: Guangdong University of TechnologyBy Xinyan Li, Mei Ma, Bilin Zhao, Na Li, Ling Fang, Donghong Wang, Tiangang Luan*Research highlightsIn this study, high-throughput multi-target immunotoxicity detection and non-targeted metabolomics technology were integrated to jointly evaluate the immunotoxicity of chlorinated polycyclic aromatic hydrocarbons and explore the immune metabolism mechanism.
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When is lupus started with immunosuppressants? How to choose 7 drugs?
Time of Update: 2023-01-06
Download the decision assistant App, the guide is free at any time ~ References: [1]2020 Chinese Systemic Lupus Erythematosus Diagnosis and Treatment Guide ▼▼▼Click to read the original article to download the AppImmunosuppressants are recommended in patients with systemic lupus erythematosus (SLE) who do not respond well to hormonal plus hydroxychloroquine, or who are unable to adjust the dose of the hormone below a relatively safe dose.
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Nature | the mechanism by which fungal virulence effectors trigger allergic inflammation
Time of Update: 2023-01-06
Madhani research group at the University of California, San Francisco, co-published a paper entitled Secreted fungal virulence effector triggers allergic inflammation via TLR4, discovering Cryptococcus neoformans The effector protein CPL1 secreted by Cryptococcus neoformans drives macrophage activation by enhancing Toll-like receptor TLR4, which causes infection in mice.
