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iNature
Psoriasis is a common chronic inflammatory skin disease
.
In recent years, the diversity and heterogeneity of human skin immune cells have been studied, but the spatial distribution of immune cells at the human psoriasis epidermis and dermal single-cell level is unclear
.
On November 8, 2022, the team of Xiaoyong Man of Zhejiang University published an online report entitled "The epidermal immune microenvironment plays a dominant role in psoriasis development, as" online in Cellular & Molecular Immunology (IF=22).
revealed by mass cytometry", which uses mass spectrometry flow cytometry to reveal the dominant role
played by the epidermal immune microenvironment in the development of psoriasis.
The study uses mass spectrometry flow cytometry to map psoriasis skin immune cells
from paired lesions, perilesions, and non-lesional skin samples.
Dendritic cells (DCs)
are visible in both the epidermis and dermis of psoriasis.
Psoriasis dermal CD1c+CD11b+cDC2s migrate to the peridermis in the early stage of initiation.
CD1c+CD11b+cDC2s rapidly replace EpCAM+CD11clowLC cells and trigger inflammation
.
At the same time, CD207+CD11chiLC and CD5+ T cells accumulate in the psoriasis epidermis and synergize with psoriasis epidermal inflammation
.
The psoriasis dermal immune cell bank mainly includes APCs and T cells
.
However, unlike the immune environment of the dermis, the immune environment of the epidermis is more pronounced and consistent with
the inflammation that occurs in psoriasis.
.
The epidermis, dermis, and subcutaneous tissue make up the skin, and the papilla of the epidermis and dermis layer are the main part of
the skin's immune microenvironment.
Abundant skin-resident and skin-infiltrating immune cells in the innate and adaptive immune systems induce different protective and pathogenic immune responses
.
In addition to immune cells, non-immune components in the skin, such as keratinocytes, play an important role
in the interaction with immune cells through soluble mediators.
Cytokines released by immune cells affect the activation and proliferation of non-immune cells and form complex inflammatory networks
during the initiation, spread, and maintenance of skin inflammation.
Psoriasis epidermal environment (Cellular & Molecular Immunology) Psoriasis is a common chronic inflammatory skin disease that affects about 125 million people worldwide and is mediated by multiple immune
responses.
The pathogenesis of psoriasis is complex and has not been fully elucidated
.
Lymphoid cells (LCs), plasma cell dendritic cells (pDCs), myeloid dendritic cells (mDCs), Th1 cells, Th17 cells, CD8+ T cells, macrophages (MACs), and innate lymphoid cells (ILCs) are involved in the development and progression
of psoriasis.
Dendritic cells are thought to be the main drivers of
psoriasis.
In addition, macrophages, T cells, and LCs interact with keratinocytes, leading to psoriasis inflammation
.
The heterogeneity of cutaneous DCs compared to circulating DC subtypes has not been fully elucidated
.
Several functionally distinct epidermal and dermal DC subtypes are highlighted
through the accumulation of TNF-α, IL-12, and IL-23 production and contribution to the inflammatory environment.
The IL-23/IL-17 axis is thought to be the central pathway in the immune pathway
involved in the pathogenesis of psoriasis.
In addition, heterogeneous T cells, such as Th1 cells, Th2 cells, Th17 cells, Th9 cells, T follicular helper cells (Tfhs), regulatory T cells (Tregs), and CD8+ cells, have been found to infiltrate psoriasis skin, all of which are involved in the tissue inflammatory process
.
However, a more comprehensive phenotypic and functional description of these cells is needed to further understand the epidermal and dermal immune microenvironment, particularly at different stages
of psoriasis inflammation.
The study uses mass spectrometry flow cytometry to reveal the dominant role
played by the epidermal immune microenvironment in the development of psoriasis.
The study uses mass spectrometry flow cytometry to map psoriasis skin immune cells
from paired lesions, perilesions, and non-lesional skin samples.
Dendritic cells (DCs)
are visible in both the epidermis and dermis of psoriasis.
Psoriasis dermal CD1c+CD11b+cDC2s migrate to the peridermis in the early stage of initiation.
CD1c+CD11b+cDC2s rapidly replace EpCAM+CD11clowLC cells and trigger inflammation
.
At the same time, CD207+CD11chiLC and CD5+ T cells accumulate in the psoriasis epidermis and synergize with psoriasis epidermal inflammation
.
The psoriasis dermal immune cell bank mainly includes APCs and T cells
.
However, unlike the immune environment of the dermis, the immune environment of the epidermis is more pronounced and consistent with
the inflammation that occurs in psoriasis.
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—END—
The content is [iNature]
