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Gout New England Journal of Medicine
Time of Update: 2023-01-06
Since the American College of Physicians issued guidelines for symptom avoidance through treatment, there has also been more evidence in favor of standard treatments, including the results of a trial evaluating nurse-led interventions that showed that standard urate-lowering therapy reduced gout attack frequency and tophi (Table S2).
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Gout New England Journal of Medicine
Time of Update: 2023-01-06
Since the American College of Physicians issued guidelines for symptom avoidance through treatment, there has also been more evidence in favor of standard treatments, including the results of a trial evaluating nurse-led interventions that showed that standard urate-lowering therapy reduced gout attack frequency and tophi (Table S2).
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Leflunomide medication 4 major misunderstandings, have you stepped on the pit?
Time of Update: 2023-01-06
Since the vast majority of rheumatic immune diseases are chronic diseases, and many patients need to take drugs for a long time or even for life, this article organizes the drug experience of leflunomide in rheumatic immune diseases, and analyzes the four most common medication misunderstandings to improve the safety of patients.
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Science: Your rheumatoid arthritis may be related to gut bacteria!
Time of Update: 2023-01-06
Click "Read Original" to get more clinical dry goodsThis study identified gut bacteria associated with RA risk through human trials and animal model experiments that trigger RA-like diseases in animal models, triggering RA-specific immune responses in humans.
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Immunity ATP binds to the transporter ABCC1 to transport the immunotransmitter cGAMP outside the cell
Time of Update: 2023-01-06
Stetson's research group from the University of Washington published a report on Immunity titled ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP In the paper, it was found that ATP-binding transporter ABCC1 is an important factor in transporting cGAMP out of the cell.
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What's new in RA? What is updated in the EULAR guidelines? One article mastered!
Time of Update: 2023-01-06
Come to the "doctor's station" and take a look 👇Safety of bDMARDs versus tsDMARDsAlarge study (Figure 2) including data from the registries of RA patients in 16 countries found no significant difference in discontinuation rates due to adverse effects between csDMARDs, TNF-α inhibitors, and JAK inhibitors.
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Nature sub-journal: Land team development of antibody research models based on artificial intelligence technology
Time of Update: 2023-01-06
。 DeepAAI is different from the classical sequence alignment method, but through the method of deep learning "dynamically and adaptively" learning the relationship between unknown antibodies and known antibodies (Adaptive Relation Graph), thereby avoiding the problem of cold start of unknown antibodies by AI algorithms and effectively predicting the neutralization ability of unknown antibodies 。 In addition, DeepAAI also has good explanatory properties and can provide clues for the binding sites of antigens and antibodies.
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Nature sub-journal: Land team development of antibody research models based on artificial intelligence technology
Time of Update: 2023-01-06
。 DeepAAI is different from the classical sequence alignment method, but through the method of deep learning "dynamically and adaptively" learning the relationship between unknown antibodies and known antibodies (Adaptive Relation Graph), thereby avoiding the problem of cold start of unknown antibodies by AI algorithms and effectively predicting the neutralization ability of unknown antibodies 。 In addition, DeepAAI also has good explanatory properties and can provide clues for the binding sites of antigens and antibodies.
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Immunity The mystery of longevity and function of anti-smallpox memory B cells in the human body
Time of Update: 2023-01-06
Overall, the researchers isolated and analyzed B5-specific MBCs from people vaccinated more than 40 years ago, and only a few clones that exhibited limited intraclone diversity, which were enriched in CD21hiCD20hi IgG+, persisted for a long time In the subpopulation of spleen B cells, NOTCH/MYC expression characteristics in the marginal region are exhibited.
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Blow the rallying horn! A quick overview of the latest news on the lupus space at ACR 2022
Time of Update: 2023-01-06
*For medical professionals onlyACR 2022 Weekly Hot Research Forecast, focusing on cutting-edge progress in the field of lupus. The 2022 American College of Rheumatology (ACR) Annual Meeting will take
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Bacterial infections cause inflammation, but give you more protection after vaccination?
Time of Update: 2023-01-06
Figure 2 Research results (Source: [1])The researchers first assessed the contribution of sociological factors (age, sex, ethnicity) and vaccine factors (vaccine platform, target pathogen, time after vaccination) to the transcriptome variance of blood samples.
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Focus on the unmet clinical needs in autoimmune diseases and grow together with the field of immunity in China!
Time of Update: 2023-01-06
*For medical professionals onlyJoin hands with the big coffee, please look forward to an academic feast in the field of rheumatic immunity and skin immune diseases!Immune-mediated inflammatory disease
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Ding dong! Check the 2022 ACR Today Hot Express to unlock the latest data of the Hopkins Lupus Queue
Time of Update: 2023-01-06
Chinese Journal of Internal Medicine,2020(03):172-173-174-175-176-177-178-179-180-181-182-183-184-185 [6]RealWorld Effectiveness of Belimumab in Patients with SLE in the United States[7] Unfavorable Outcomes Associated with Current Standard of Care in the Management of Patients with Systemic Lupus Erythematosus[8] Association Between Cumulated Hydroxychloroquine in Systemic Lupus Erythematosus and Development of Cardiac Conduction Alterations: A Multiple Logistic Regression Analysis[9] World Health Organization.
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Nature sub-issue: A new mechanism to fight immune aging! Scientists have found that antigen-presenting cells actively present telomeres to T cells, helping T cells prolong their life
Time of Update: 2023-01-06
In the immune memory stage, Tel+T significantly prolongs the survival of miceIn summary, Professor Alessio Lanna's research team found that APCs "selflessly" their telomeres to T cells, thereby helping T cells "survive", enhance immune responses and stabilize long-term immune memory.
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How can rheumatism patients be screened for and prevented for infection? The first EULAR guide is here!
Time of Update: 2023-01-06
Before using traditional synthetic disease-modifying antirheumatic drugs (csDMARDs), targeted synthetic DMARDs (tsDMARDs), biologic DMARDs (bDMARDs), immunosuppressants, and/or glucocorticoid therapy, the risk of chronic and opportunistic infections should be discussed with all patients with AIIRD and reassessed regularly.
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How can rheumatism patients be screened for and prevented for infection? The first EULAR guide is here!
Time of Update: 2023-01-06
Before using traditional synthetic disease-modifying antirheumatic drugs (csDMARDs), targeted synthetic DMARDs (tsDMARDs), biologic DMARDs (bDMARDs), immunosuppressants, and/or glucocorticoid therapy, the risk of chronic and opportunistic infections should be discussed with all patients with AIIRD and reassessed regularly.
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"Immunology" heavy! The mastermind behind the fact that supplementing probiotics is difficult to colonize! Scientists have found that autoimmune-related genes affect the colonization of probiotics in the gut of infants
Time of Update: 2023-01-06
Issue 241 | Gut Jun Weekly Probiotic colonization, autoimmune-related genes; COVID-19； Autoimmune-associated genetics impact probiotic colonization of the infant gut Multi-kingdom gut microbiota analy
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"Immunology" heavy! The mastermind behind the fact that supplementing probiotics is difficult to colonize! Scientists have found that autoimmune-related genes affect the colonization of probiotics in the gut of infants
Time of Update: 2023-01-06
Issue 241 | Gut Jun Weekly Probiotic colonization, autoimmune-related genes; COVID-19； Autoimmune-associated genetics impact probiotic colonization of the infant gut Multi-kingdom gut microbiota analy
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Bacterial infections cause inflammation, but give you more protection after vaccination?
Time of Update: 2023-01-06
Figure 2 Research results (Source: [1])The researchers first assessed the contribution of sociological factors (age, sex, ethnicity) and vaccine factors (vaccine platform, target pathogen, time after vaccination) to the transcriptome variance of blood samples.
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8 Cell/Nature/Science Gao Fu, He Dayi, Yuan Guoyong and other teams revealed the potential mechanism of Omicron's antibody escape and rapid spread
Time of Update: 2023-01-06
iNatureThe coronavirus disease 2019 pandemic continues to affect people around the world. The rapid development and deployment of effective vaccines, as well as monoclonal antibody therapies, from the
