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Nature sub-journal sciPENN, a multi-purpose deep learning method that predicts and imputes scRNA-seq and CITE-seq protein expression
Time of Update: 2023-01-04
The research team has developed a versatile deep learning method, sciPENN, that supports CITE-seq and scRNA-seq data integration, enabling prediction, imputation of scRNA-seq, CITE-seq protein expression, quantification of uncertainty, and transfer of cell type markers from CITE-seq to scRNA-seq.
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Neurology cases: seen in abdominal reflex separation in rheumatoid atlantoaxial subluxation
Time of Update: 2023-01-04
A 59-year-old woman with rheumatoid arthritis presents with shock-like pain triggered by progressive gait difficulty and neck flexion (Lhermitte sign) for more than 6 months. On examination, the patie
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Carl June, the father of CAR-T, commented: Beyond cancer, CAR-T successfully treats lupus erythematosus
Time of Update: 2023-01-04
On November 23, 2022, Professor Carl June, the "father of CAR-T" and the University of Pennsylvania, published a review article in the journal Cell entitled: CAR-T therapy extends its reach to autoimmune diseases [1], commenting on the very promising effect of CAR-T cell therapy in the treatment of patients with the autoimmune disease systemic lupus erythematosus.
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Bad habits that you don't notice may affect your lupus condition!
Time of Update: 2023-01-04
Legs, playing with mobile phones before going to bed, eating and drinking, taking hot baths, not drinking water on time.
Legs, playing with mobile phones before going to bed, eating and drinking, taking hot baths, not drinking water on time.
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Clinical features and management of late-onset systemic lupus erythematosus
Time of Update: 2023-01-04
Late-onset systemic lupus erythematosus (LSLE) refers to the patient's clinical symptoms first occurring after the age of 50, accounting for about 2% ~ 20% of SLE, although the proportion is low, but due to the insidious onset of the disease, the clinical manifestations are heterogeneous, it is easy to miss and misdiagnose, and the mortality rate of LSLE is higher than SLE, so it is necessary to timely and accurate diagnosis and treatment.
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Rheumatology: HOXA5 is a key regulator of the expression of 3 types of signaling proteins in the synovial membrane of rheumatoid arthritis patients
Time of Update: 2023-01-04
synovial tissue, human umbilical vein endothelial cells (HUVECs) and RA fibroblast-like synovial cells (FLS)of TCF-3, EBF-1, and HOXA5Results: Compared with IAR patients, mRNA expression of all 3 types of signaling proteins in the synovial membrane of RA was significantly reduced.
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Shanghai Materia Medica: Medicinal and food cognate
Time of Update: 2023-01-04
In traditional medicine, the two elixirs of water and land are used to treat sperm loss and bring down; Yusuo Dan treatment of dream slippery essence; Distinguish clear pills to treat white turbidity.
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4 days to eliminate aging! This immune cell impresses scientists
Time of Update: 2023-01-04
Studies have found that due to factors such as age and obesity, the number and activity of iNKT cells are greatly reduced, resulting in an increase in senescent cells in the body, which in turn leads to the occurrence of chronic diseases.
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Organoid techniques and mouse models of lung injury to evaluate the effect of hydroxychloroquine on lung epithelial regeneration
Time of Update: 2023-01-04
had little to no impact on the regenerative capacity of lung epithelial stem/progenitor cells, reducing concerns about potential fibrosis progression in recovered COVID-19 patients receiving HCQ.
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How can streptococcal infection cause psoriasis?
Time of Update: 2023-01-04
Lao Zhang is a big pig farmer in the village, and over the years, he has not only made his family live a good life by raising pigs, but also helped the village build roads and bridges, which was prais
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Experts remind: how serious systemic lupus erythematosus is, you can't just look at the symptoms
Time of Update: 2023-01-04
"The big wolf is called the little wolf bite"Disease activity cannot be judged solely by symptomsSLE is an autoimmune disease that can cause damage to multiple organs and tissues such as kidneys, blood system, nervous system, digestive system, cardiovascular, lung, skin, and eyes, and failure to receive timely and effective treatment will significantly increase the risk of death.
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Pharmacokinetics of hydroxychloroquine in pediatric lupus
Time of Update: 2023-01-04
To overcome existing gaps in PK and exposure response data in children, a novel direct-to-home clinical trial was conducted in pSLE using electronic vial caps to improve adherence to HCQ.
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C-reactive protein = inflammation? Perhaps overlooked more
Time of Update: 2023-01-04
7. 24~72 h after surgery, the level of CRP in the blood increased significantly, and returned to normal on the 5~7th day.
7. 24~72 h after surgery, the level of CRP in the blood increased significantly, and returned to normal on the 5~7th day.
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Front Pharmacol: Traditional Chinese medicine formulation for the treatment of rheumatoid arthritis in women, a study protocol for a double-blind, randomized, placebo-controlled trial
Time of Update: 2023-01-04
Discussion: This trial will provide evidence for KBXG in reducing disease activity and improving clinical symptoms and quality of life in women with RA.
This trial will provide evidence for KBXG in reducing disease activity and improving clinical symptoms and quality of life in women with RA.
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Uncorrectable red blood cell agglutination, what exactly is the result?
Time of Update: 2023-01-04
PrefaceThe phenomenon of red blood cell condensation set, everyone may not be unfamiliar, through the general warm bath can solve more than 90% of the red blood cell agglutination problem, but the cas
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Rheumatology: elevated serum CA72-4 predicts gout attacks at the start of urate-lowering therapy, a prospective cohort study
Time of Update: 2023-01-04
The aim of the study was to determine whether serum CA72-4 is an independent predictor of gout attacks during ULT initiation.
High serum CA72-4 predicts the risk of gout attacks during ULT initiation Sources:Sources:Hu S, Sun M, Li M, et al.
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Can miscarriage and rheumatism also be related?
Time of Update: 2023-01-04
have shown that the incidence of miscarriage in pregnant patients with Sjogren's syndrome is significantly higher than that in healthy control groups, and anti-SSA antibodies are associated with spontaneous abortion, but the sample size of the study is not large.
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Shy, talk about the sex life of lupus patients (minor patients should be cautious)
Time of Update: 2023-01-04
[2]Image source: PhotogramOral contraceptive pills | contraceptionA number of prospective studies of lupus-related thrombosis risk assessment have shown that for patients with lupus who are inactive or in a stable phase and have negative antiphospholipid antibody levels, taking combined oral contraceptives containing estrogen and progestogens does not increase the risk of disease recurrence, and can also help prevent osteoporosis and improve fertility.
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The latest ACR guidelines recommend vaccination for people with rheumatology and musculoskeletal diseases
Time of Update: 2023-01-04
Recently, the American College of Rheumatology (ACR) published a summary of new guidelines for vaccinating patients with rheumatology and musculoskeletal disorders (RMD).
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J Ethnopharmacol: White peony total glycoside alleviates scleroderma by inhibiting type I interferon responses
Time of Update: 2023-01-04
white peony total glycoside (TGP),JAK-STAT signaling pathwayIn a BLM-induced mouse model of scleroderma, TGP improves skin fibrosis by inhibiting multiple targets upstream and downstream of type I IFN signaling.
