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A&R: Low concentrations of C5a complement receptor antibodies are associated with disease activity and relapse in ANCA-associated vasculitis
Time of Update: 2023-01-04
Conclusion: Low concentrations of anti-C5aR antibodies reflect disease activity and are associated with an increased risk of AAV recurrence.
Low concentrations of anti-C5aR antibodies reflect disease activity and are associated with an increased risk of AAV recurrence Sources:Sources:Klapa S, Müller A, Koch A, et al.
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Do you know the relationship between obesity and osteoporosis?
Time of Update: 2023-01-04
Obese people generally eat more and exercise less, resulting in hormone imbalance and fat accumulation in the body, and this lifestyle habit is one of the risk factors for osteoporosis; In addition, many obese people will be accompanied by diabetes, cardiovascular diseases and other diseases, which will increase secondary osteoporosis.
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Rheumatology: rheumatoid arthritis macrophages respond to inflammation and exhibit changes in bioenergetic and functional
Time of Update: 2023-01-04
unique inflammatory and metabolic phenotype of RA monocytes-derived macrophages and identifies the key roles of NAMPT and STAT3 signaling in regulating this phenotype Sources:Sources:Hanlon MM, McGarry T, Marzaioli V, et al.
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Effect of add-on hydroxychloroquine therapy on serum pro-inflammatory cytokine levels in patients with systemic lupus erythematosus
Time of Update: 2023-01-04
The results of this study suggest that add-on HCQ therapy can modulate the expression of pro-inflammatory cytokines even in patients with systemic lupus erythematosus with low disease activity.
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A summary of rheumatology test items
Time of Update: 2023-01-04
RF positive for rheumatic diseases such as systemic lupus erythematosus, Sjogren's syndrome, vasculitis, etc.
RF positive for rheumatic diseases such as systemic lupus erythematosus, Sjogren's syndrome, vasculitis, etc.
RF positive for rheumatic diseases such as systemic lupus erythematosus, Sjogren's syndrome, vasculitis, etc.
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Is lupus erythematosus, which can be cured, really exist?
Time of Update: 2023-01-04
For patients with drug-induced cutaneous lupus erythematosus-like manifestations, symptoms are generally relieved after a few weeks of discontinuation and do not require specific treatment.
For patients with drug-induced cutaneous lupus erythematosus-like manifestations, symptoms are generally relieved after a few weeks of discontinuation and do not require specific treatment.
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Winter rheumatoid attack? How to prevent it effectively
Time of Update: 2023-01-04
At the same time, patients who have been diagnosed with rheumatoid are not properly cared for in winter, and the evil invasion of wind and cold is also easy to lead to recurrence.
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IgG4-related diseases! How to tell?
Time of Update: 2023-01-04
The clinical features of the main organs affected are as follows:01 Salivary glandsLarge sialadenitis is most common in IgG4-RD and typically presents with bilateral or unilateral painless enlargement of the submandibular, parotid gland, or sublingual glands, hard texture on palpation, and may be accompanied by dry mouth.
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Gout actually hurts the kidneys?! How can I protect my kidneys?
Time of Update: 2023-01-04
If high uric acid is not controlled for a long time, a large amount of uric acid in the blood of gout patients meets electrolytes to form urate, which is continuously deposited into the kidneys, and kidney damage will occur, resulting in renal insufficiency, and even uremia, which is life-threatening in severe cases!Simply put, hyperuricemia or gout that cannot be effectively treated is the root cause of "kidney damage".
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How long do we have to defeat SLE?
Time of Update: 2023-01-04
Quietly speaking, Mutual Aid Jun has contacted many "gold-medal" lupus patients, and can even achieve "zero hormone" medication, and their attitude is undoubtedly very optimistic, and they are also very cooperative with doctors for active treatment, hoping that all butterfly friends can learn from these "gold-medal" lupus patients.
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Gouty arthritis
Time of Update: 2023-01-04
1. Does hyperuricemia necessarily have gout?Not patients with hyperuricemia will definitely get gout, gout is because uric acid in the form of crystals precipitated, gathered in the joints and other places, resulting in joint redness, swelling, heat and pain of the inflammatory reaction, in hyperuricemia patients only 5%-12% of patients will become gouty arthritis, but long-term high uric acid on the cardiovascular and cerebrovascular and kidney burden can not be ignored.
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Picking your nose increases the risk of Alzheimer's disease and dementia
Time of Update: 2023-01-04
Griffith University, Australia, was founded in 1971 Researchers have shown that a bacterium can enter the brains of mice through the olfactory nerves of the nose, where it produces markers of Alzheimer's disease.
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J Ethnopharmacol: White peony total glycoside alleviates scleroderma by inhibiting type I interferon responses
Time of Update: 2023-01-04
white peony total glycoside (TGP),JAK-STAT signaling pathwayIn a BLM-induced mouse model of scleroderma, TGP improves skin fibrosis by inhibiting multiple targets upstream and downstream of type I IFN signaling.
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Nat Immunol and Zhang Zhirong et al. revealed a new mechanism that activates innate immunity - NLRP3 inflammasome sensing endosomal stress
Time of Update: 2023-01-01
The inflammasome is a multiprotein polymeric complex that plays a key role in the innate immune response caused by pathogen invasion or tissue damage. Classical inflammasome are composed of pattern re
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Nat Cell Biol's team has revealed a new strategy to overcome immunotherapy resistance by delivering cytokine IL-2 through mesenchymal stem cells
Time of Update: 2023-01-01
By modifying mesenchymal stem cells, the authors achieved controllable IL-2 delivery to targeted tumors, effectively controlled tumors in a variety of mouse tumor models, and was able to break anti-PD-L1 drug resistance.
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2022 Ankylosing Spondylitis Diagnosis and Treatment Guidelines Released! Hot spots for a sneak peek
Time of Update: 2023-01-01
Recently, the Rheumatology Branch of the Chinese Medical Association formulated this code [1] on the basis of drawing on domestic and foreign experience and treatment experience and guidelines, aiming to standardize the diagnosis and condition assessment of AS, rationally use nonsteroidal anti-inflammatory drugs (NSAIDs), biological and traditional synthetic antirheumatic drugs (DMARDs), and improve the quality of life of patients.
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Nat Immunol—Zhirong Zhang et al. unveil a new mechanism of innate immune activation: NLRP3 inflammasome sensing changes in endosomal composition under endosomal stress
Time of Update: 2023-01-01
Source—“Sister of the Logical Scripture Science“ Lanhan Life Sciences" Written by Maki Editor- Wang Sizhen ， Edited by Binwei Yang, Sizhen Wang The inflammasome is a multi-protein polymeric complex th
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STTT makes progress! Cao Xuetao's team and others depicted the natural immune map of Omicron-infected people
Time of Update: 2023-01-01
Information: style="margin-right: auto;margin-left: auto;outline: 0px;width: 30px;display: inline-block;">—END—The content is [iNature]iNatureIn vaccinated people, SARS-CoV-2 Omicron variant infection typically results in asymptomatic to moderate COVID-19.
Information: style="margin-right: auto;margin-left: auto;outline: 0px;width: 30px;display: inline-block;">—END—The content is [iNature]iNatureIn vaccinated people, SARS-CoV-2 Omicron variant infection typically results in asymptomatic to moderate COVID-19.
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Why are there more and more patients with gout? These "banes" were picked out! How to intervene and treat?
Time of Update: 2023-01-01
g. , low-calorie diet, low-purine diet) showed that uric acid reductions from these interventions were generally small (); In addition, there are guidelines that the goal of gout treatment is to achieve resolution of patient-related symptoms (eg, long-term use of colchicine, NSAIDs, or glucocorticoids in the absence of urate-lowering therapy).
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What is the difference between febuxostat, allopurinol, and benzbromarone? An article that you can read
Time of Update: 2023-01-01
Allopurinol, febuxostat and benzbromarone are commonly used urate-lowering drugs in China, what are the differences between these three drugs?01Urate-lowering drug selection strategiesFebuxostat is only approved for the long-term treatment of hyperuricemia in patients with gout and is not recommended for asymptomatic hyperuricemia.
