How long do we have to defeat SLE?

If there is any common wish of all butterfly friends, hoping that lupus can be cured must be the first priority
.
From the initial antimalarial drugs to the later biological agents, lupus treatment drugs have undergone changes from generation to generation, and the quality of life of butterfly friends is getting higher and higher, but the hope of "cure" is still deeply rooted in the hearts
of many patients.

So, how long do we have to defeat the disease of systemic lupus erythematosus? Today, Mutual Aid Jun will discuss this issue with you
.
Why is SLE so hard to cure?

01The pathogenesis factors are complex and there are many symptoms

Systemic lupus erythematosus is a systemic autoimmune disease, there are many factors, genetics, sex hormones, autoimmune factors, environment may be part of the disease, in other words, each person's cause may be different
.

At the same time, the characteristics of systemic lupus erythematosus are easy to involve a variety of organs throughout the body, such as kidneys, blood system, liver, heart, lungs, etc.
, almost all organs of the whole body may be affected, which determines the ever-changing symptoms of lupus, so the difficulty of treatment has also increased a lot, and doctors need to develop a personalized plan
according to the patient's situation.

02The immune system is complexly regulated

The essence of the pathogenesis of lupus is that the immune system is disordered, and the B cells in the body proliferate and differentiate actively, producing a large number of autoantibodies, which participate in immune damage by forming immune complexes, activating complement and conditioning phagocytosis, while T cells are responsible for directly killing cells to cause immune damage
.
However, dysregulation of B cell and T cell activation can only explain the pathogenesis of lupus as a whole, and there are multiple immune checkpoints expressed on B cells and T cells, which may be involved in the pathogenesis of SLE [1].

If butterfly friends find it difficult to understand, Mutual Aid Jun here to give you an example, B cells are scouts, and T cells are snipers, lupus occurs because B cells detect errors, recognize their own organs as invading viruses, bacteria and other foreign substances, release "sniping" signals, and T cells after receiving sniping instructions, mistakenly attack their own organs
。 But there are many "soldiers" responsible for transmitting signals between B cells and T cells, these are "immune checkpoints", in the process of B cell detection and T cell sniping, there are immune checkpoints to transmit signals, once there is a problem with one of the checkpoints, it may lead to signal errors, resulting in SLE
.

However, our current research on immune checkpoints has not been fully in-depth, and the number of immune checkpoints is very large, so it is difficult for us to know which link of SLE is wrong, and it is difficult to achieve real precision treatment
.

Lupus is cured and the future can be expected

But butterfly friends should not be busy discouraged, even if lupus cannot be completely cured at present, but medicine continues to advance, and the prognosis of lupus is constantly improving
.
Previous hormones, hydroxychloroquine, immunosuppressants and other traditional drugs are widely used in the immune system, while controlling diseases, they also have certain toxic side effects
.
The advent of biologics has ushered in a new era of targeted therapy, and combination with conventional therapy has brought new options
to SLE patients.

In addition, more and more genes and targets related to lupus have been discovered, which also indicates that we are getting closer to a cure
.
Here, Mutual Aid Jun shares some new developments
in lupus for everyone.

01 New advances in genetics

In recent years, at least 80 genes have been found to be associated with SLE [2], indicating that SLE is not a single-gene genetic disease, but a complex disease
with a certain genetic predisposition dominated by multiple genes.

The latest genome-wide association study of Han Chinese people in China showed that nine new susceptibility sites (ETS1, IKZF1, RASGRP3, SLC15A4, TNIP1, 7q11.
23, 10q11.
22, 11q23.
3, 16p11.
2) and also identified six previously reported gene loci (BLKIRF5, STAT4, TNFAIP3, TNFSF4, 6q21, 22q11.
21) [3]
。 The results show that there are differences
in the genetic susceptibility of SLE in the Han ethnic group in China, European population and African population.

02New progress in targeting

Related targets can be mainly divided into B cell / plasma cell targets, T cell targets, macrophage targets, intracellular signaling molecules, co-stimulatory factors, cytokines, IgE autoantibodies, intestinal flora 8 kinds, because each related target has many kinds, here mutual aid Jun will not introduce one by one, but the progress of these targets can undoubtedly provide new evidence
for subsequent lupus treatment.

If you want to know more, you can reply to the code: literature in the background

03New advances in treatment

In addition to the innovative treatment of biologics, these are also expected to become new means
of lupus treatment.

○ Allogeneic mesenchymal stem cell therapy (For details, see this article "Exciting! Cutting-edge therapy interpretation that SLE patients must not miss! 》）

○ CAR-T therapy (For details, see this article "Cutting-edge information! CAR-T treatment of systemic lupus erythematosus has made new progress again! 》）

○ Artemisinin (For details, you can see this article ""Oriental miracle medicine" artemisinin, can it really cure lupus?) 》）

○ A variety of monoclonal antibody injections

It is believed that as more and more therapeutic targets are discovered, there will be more and more
drug options for lupus.

Before curing lupus,

What can we do?

01 Stay confident

From the above research we can see that the treatment of lupus has been constantly improving, although we are not yet sure when it can be cured, but may as well give our scientists more confidence, at present, our country also attaches great importance to the construction of rheumatology and immunology, to believe that more and more researchers and medical staff will join this team
.
The only thing we need to do is wait and wait, and perhaps inadvertently, we have the exciting news that "lupus can finally be cured!" ”

02Standardized treatment

Trusting your primary care physician, receiving standard treatment and regular follow-up, we can control the disease very steadily
, even if lupus is not cured.
Quietly speaking, Mutual Aid Jun has contacted many "gold-medal" lupus patients, and can even achieve "zero hormone" medication, and their attitude is undoubtedly very optimistic, and they are also very cooperative with doctors for active treatment, hoping that all butterfly friends can learn
from these "gold-medal" lupus patients.

03Understand your condition

Due to the different symptoms of lupus, butterfly friends should learn to understand their condition, and personal feelings are actually very important
when visiting the doctor for review.
When butterfly friends have symptoms such as joint pain, hair loss, fever, fatigue, abdominal pain, nausea, headache, memory loss, increased nocturia, abnormal urine output, etc.
, remember to review in time and communicate with the attending doctor
.
Describing symptoms can tell you what changes your body has seen in recent days that are suspected of recurring lupus, but don't overstate subjective feelings
.

04Pay attention to daily care

○ Sun protection: ultraviolet rays may induce erythema, aggravate skin inflammation, travel should try to avoid the period of strong ultraviolet rays, travel is best to wear a sunscreen hat, wear a sunscreen clothing, you can also choose a mild texture sunscreen
.

○ Diet: light, less salt, less oil, less sugar, light-sensitive butterfly friends should try to eat less coriander, celery, mud snails, lemons, mushrooms and other photosensitive foods, butterfly friends who are prone to allergies should eat less seafood
.
○ Exercise: moderate exercise can help you reduce the fatigue caused by the disease, it is recommended that butterfly friends choose swimming, tai chi, yoga, eight dan jin, slow walking and other soothing exercises, patients with joint pain try not to choose skipping rope, long-distance running, squats and other sports
that may damage the knee joint.
Exercise intensity can be three to five times a week, each time 30 ~ 45min, specific to personal feelings are appropriate, in general, the next day of exercise will not feel tired means that the exercise intensity is appropriate, if the next day is sore, indicating excessive exercise
.

How long do we get from curing systemic lupus erythematosus? No one can be sure of this answer, but Mutual Aid Jun believes that as long as you have confidence, the future of butterfly friends will definitely get better and better!

What is the relationship between immunity and lupus?

So it is!