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Immunity "Hit the snake seven inches" - an epitope target that EBV is easily neutralized and inhibited by fusion
Time of Update: 2023-01-01
MG collaborated to publish an article in the journal Immunity Epstein-Barr virus gH/gL has multiple sites of vulnerability for virus neutralization and fusion inhibition Using a variety of serology, biochemistry, structural biology methods and humanized mouse challenge models, the epitope structure information on EBV gH/gL that is easily neutralized and inhibited by fusion was systematically revealed, which laid a theoretical foundation for understanding EBV invasion and infection of cells and developing preventive or therapeutic vaccines.
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Studies reveal the mechanism by which Ixodes tick salivary adenotoxins promote Lyme disease transmission
Time of Update: 2023-01-01
revealed the mechanism of Ixodes tick salivary gland toxin promoting Lyme disease transmissionSource: Kunming Institute of Zoology, Chinese Academy of SciencesThis account manuscript opens WeChat "Quick Reprint" by defaultPlease indicate the source of reproductionFor other channels to reprint, please contact weibo@cashq.
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PBJ uses monoclonal antibodies that successfully express the SARS-CoV-2 Omicron variant in plant cells to effectively neutralize variant strains and have synergistic effects with other antibodies
Time of Update: 2023-01-01
(1) Expression of anti-SARS-CoV-2 RBD monoclonal antibody in tobaccoMice were pretreated and immuno-enhanced with protocols, hybridoma was screened for immunogen (Wuhan-Hu-1 RBD) responsiveness and several strongly reactive antibodies were identified, and an 11D7 was selected for variable region gene rescue 。 Mouse light and heavy chain variable regions were transplanted into human κ and human γ constant regions, respectively, resulting in chimeric mAbs that were codons suitable for plant expression and expressed transiently in ΔXFT N.
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Interpretation |Sun Yat-sen University: Pik3ip1, a novel immunonegative regulatory molecule, regulates the progression of autoimmune diseases by metabolic reprogramming to maintain the resting state of T cells
Time of Update: 2023-01-01
In a new study, the team of Professor Wang Zhi of the Affiliated Hospital of Stomatology of Sun Yat-sen University confirmed that the novel immune negative regulatory molecule Pik3ip1 helps maintain T cell metabolic homeostasis, and the loss of Pik3ip1 promotes the progression of autoimmune diseases.
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How is inflammatory myopathy diagnosed? These "traps" to avoid!
Time of Update: 2023-01-01
Professor Albayda introduced the role of auxiliary examinations in the diagnosis of inflammatory myopathy, and combined with the latest advances in the field, introduced the contribution of serological testing, imaging, electromyography and histopathology to the diagnosis of myositis.
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Hormone therapy for lupus, dose adjustment varies from person to person
Time of Update: 2023-01-01
[3] 2020 Chinese guidelines for the diagnosis and treatment of systemic lupus erythematosus ▼▼▼Click to read the original article to download the AppFor more questions about the diagnosis of common rheumatology diseases, take a look at the "Clinical Decision App"!
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This type of rheumatoid arthritis, can it be good without medicine?
Time of Update: 2023-01-01
*For medical professionals onlyIs it still targeted for a blind man to touch an elephant? Subclinical rheumatoid arthritis (subclinical RA) refers to a state in which patients are autoantibody positiv
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Jci Nanjing University Chen Xi/Yan Chao/Yin Rong discovered that the cancer-causing KRAS signaling pathway evades innate immune surveillance of lung adenocarcinoma by activating CD47
Time of Update: 2023-01-01
On November 22, 2022, Chen Xi, Yan Chao and Yin Rong of Nanjing University jointly published a report entitled "Oncogenic KRAS signaling drives evasion of innate immune surveillance in lung" online in the Journal of Clinical Investigation (IF=19).
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Eleonora Macchia team at Åborough Academic University, Finland. Sensor: Optimized immunoglobulin detection and experimental technology design based on ultrasensitive sandwich immunoassay
Time of Update: 2023-01-01
In recent years, the identification of proteins, peptides, and genetic markers using femmole detection limits has become a fundamental task for early diagnosis.
comIn recent years, the identification of proteins, peptides, and genetic markers using femmole detection limits has become a fundamental task for early diagnosis.
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Nat Immunol memory T cells also have ammonia detoxification: another key for Huang's team to unlock the mystery of memory
Time of Update: 2023-01-01
Editor-in-charge | XiThe metabolism of sugar, lipid and protein is the basis of all life activities, but at the same time, it inevitably produces substances that are harmful to life. Sugar and lipid m
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Science sub-issue: Cracking the mystery of iron deficiency affecting immunity! Two independent research institutions have found that iron deficiency impairs the production and function of neutrophils and affects the discovery of innate immunoscience
Time of Update: 2023-01-01
Hepcidin expression decreased in IRP1/2-deficient mice IRP1/2 deletion inhibits neutrophil productionBoth studies have shown that iron metabolism can affect neutrophil production.
Hepcidin expression decreased in IRP1/2-deficient mice IRP1/2 deletion inhibits neutrophil productionBoth studies have shown that iron metabolism can affect neutrophil production.
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Science Breakthrough/Chen Lieping's research group reveals the new role of immunology veteran CD8a
Time of Update: 2023-01-01
In 2022, Professor Lieping Chen's group, director of the Yale University Cancer Immunology Center and academician of the National Academy of Sciences, published a paper in Science to clarify the function of CD8a protein on killer CD8+ T cells in peripheral lymphoid organs in vivo [10].
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Rheumatoid arthritis medication dry goods recommendation, quickly collect!
Time of Update: 2023-01-01
Conventional synthetic DMARDs [methotrexate (MTX), leflunomide, sulfasalazine], hormones, biologics DMARDs [tumor necrosis factor inhibitors (adalimumab, setuzumab, etanercept, golimumab, infliximab, including biosimilars), abatacept, rituximab, tocilizumab, salivizumab], There are 5 general principles and 11 recommendations on the safety, efficacy and cost of targeted synthesis of DMARDs (JAK inhibitors tofacitinib, baricitinib, fegotinib, upatinib).
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STTT makes progress! Cao Xuetao's team and others depicted the natural immune map of Omicron-infected people
Time of Update: 2023-01-01
Information: style="margin-right: auto;margin-left: auto;outline: 0px;width: 30px;display: inline-block;">—END—The content is [iNature]iNatureIn vaccinated people, SARS-CoV-2 Omicron variant infection typically results in asymptomatic to moderate COVID-19.
Information: style="margin-right: auto;margin-left: auto;outline: 0px;width: 30px;display: inline-block;">—END—The content is [iNature]iNatureIn vaccinated people, SARS-CoV-2 Omicron variant infection typically results in asymptomatic to moderate COVID-19.
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How is Sjogren's syndrome diagnosed? Don't forget this check!
Time of Update: 2023-01-01
OneTear secretion test (Schirmer test)Operation procedure: in a quiet and dark light environment, the standard Schirmer filter paper is bent at the scale, gently placed into the temporal edge of the lower eyelid of the subject, the patient is instructed to close his eyes gently, retain the filter paper for 5min, take out the filter paper after 5min, and measure the length of the test strip being wetted.
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Nat Genet Zhang Zhao's group reveals the new role of reversal colons in activating the innate immune system to resist the invasion of foreign viruses for a long time
Time of Update: 2023-01-01
Reverse locons are present in almost all eukaryotes and are extremely abundant in the genome. In humans, reversers make up up to 38% of the genome. After the activation of the reverse locon, the mRNA,
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If you want to reduce the risk of gout in young people, you can start by treating metabolic syndrome!
Time of Update: 2023-01-01
Click "Read Original" to get more clinical dry goods*For medical professionals only, multi-pronged approaches may be more effectiveExecutive SummaryOn November 23, 2022, a study published in the journal Arthritis & Rheumatology showed that metabolic syndrome (MetS) is a variable risk factor for gout.
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During an acute attack of gout, these drugs can be chosen!
Time of Update: 2023-01-01
👇 Download the Decision Assistant App, the guide is free at any time ~▼▼▼Click to read the original article to download the App *For medical professionals onlyFor more ways to diagnose and treat gout, see what the guide says!
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How should immunosuppressants be used for patients with these 3 special conditions?
Time of Update: 2023-01-01
Curriculum 2022,Am J Kidney Dis. 80(3):393-405In order to better provide you with interesting, useful and attitude content, the Rheumatology and Immunology Channel of the Medical Community welcomes everyone to complete the following research with your fingers, it only takes two minutes!MMF is metabolized in the liver, anddose reduction should be considered in case of a severe decrease in renal function.
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Actively grasp the "window of opportunity" of RA treatment to help patients achieve early benefits
Time of Update: 2023-01-01
Professor Wan Weiguo from the Department of Rheumatology and Immunology of Huashan Hospital affiliated to Fudan University has been committed to the treatment of rheumatic immune diseases for many years.
