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From the medical journey of the "pioneer" of rheumatology, explore the essence of integrated Chinese and Western medicine in the treatment of RA
Time of Update: 2023-01-01
*For medical professionals onlyIntegrate the essence of traditional Chinese medicine with western medical technology, and promote the practice of standardized treatment of RA based on the integrated t
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Review of Trends in Immunology: neuro-epithelial-ILC2 interaction network and barrier tissue microenvironment homeostasis
Time of Update: 2023-01-01
▲▲Click the blue text above to follow CellPress Cell Science▲Life SciencesLife scienceBarrier tissues (such as skin, respiratory tract and digestive tract) are the body's first line of defense against external invasions and are the key structural tissues for mammals to maintain their integrity.
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How Nat Immunol NCOR1/2 is involved in B cell development and its role in B-ALL
Time of Update: 2023-01-01
Written by | QiAdaptive B cell responses rely on a diverse repertoire of mature B cells, and to ensure the production of sufficient quantity and quality of mature B cells, developing B cells undergo a
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How is lupus nephritis treated? The ultra-practical experience of the experts got it
Time of Update: 2023-01-01
, Professor Zhang Hui gave the following suggestions for combination treatment regimen for different types of LN patients:● Compared with vocyclosporine, belimumab is more suitable for patients with LN with eGFR≤45 ml/min and/or significant chronicized renal biopsy and low proteinuria ().
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Sci Immnuo BATF activates tumor-infiltrating regulatory T cells
Time of Update: 2023-01-01
Recently, Hiroyoshi Nishikawa's research group from the National Cancer Center in Japan published a report in Science Immunology titled BATF epigenetically and transcriptionally controls the activation program of regulatory T The article Cells in Human Tumors found that BATF can also regulate the function of tumor invasion regulatory T cells.
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Nature Genetics: Zhao Zhang/Lu Wang collaboration reveals a new role in reversing the colon in initiating the innate immune system to resist the invasion of exogenous viruses for a long time
Time of Update: 2023-01-01
This study systematically established a tool to detect reverse locon transposability in somatic cells, and realized real-time tracking of reverse locus jumping events at the single-cell level, thereby revealing the important role of reversal locon activation in a specific developmental period that can activate the host's innate immune system to resist the invasion of foreign viruses for a long time, which provides a new direction for studying the potential physiological function of reverse locus.
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Use methotrexate well, don't forget these 3 precautions!
Time of Update: 2023-01-01
▼▼▼Click to read the original article to download the App*For medical professionals to read and refer to more common rheumatology drugs, go to the "Clinical Decision Assistant App"!
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These 6 new developments in ANCA-associated vasculitis you don't want to miss
Time of Update: 2023-01-01
Proportion of somatic mutations in different systemic vasculitisDiffuse alveolar hemorrhage (DAH) affects the prognosis of AAVDAH is a life-threatening clinical manifestation of AAV, and studies have shown that participants with DAH differ in age, ANCA subtype and renal function, while subjects with AAV with DAH are more likely to die within 30 days and 1 year.
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Where is it "difficult" to treat refractory RA? These 11 tips to pay attention to!
Time of Update: 2023-01-01
Come to the "doctor's station" and take a look 👇*For medical professionals onlyRefractory RA is a difficult problem in clinical treatment and also brings a huge burden to patients.
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Explore the immune memory mechanism of people who have recovered from the new crown
Time of Update: 2023-01-01
Davis of Stanford University and Dr. Liang Chen (now a professor at Shanghai University) published a study1 in Nature Cell Biology, in which they used single-cell sequencing technology to delineate the multidimensional map of chromatin accessible to peripheral immune cells of recovered patients, and elucidated the epigenetic mechanism behind the formation of immune memory in recovered immune cells。Some pathogenic infections can strengthen our innate immune system.
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To cure gout with allopurinol, these 3 points you must master!
Time of Update: 2023-01-01
Click "Read Original" for more dry medicationsFor medical professionals onlyEvidence-based medicine, rational use of medicine Allopurinol and its metabolite oxypurinol can inhibit xanthine oxidase and prevent hypoxanthine and xanthine metabolism to uric acid, thereby reducing the production of uric acid.
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If you have this disease, will it affect your pregnancy attempt?
Time of Update: 2023-01-01
How to deal with organ and system involvement in pregnant mothers?More guidelines for systemic lupus erythematosus can be found in the Clinical Decision AppIt can also support one-click translation of English guidesReferences:[1] 2020 Chinese guidelines for the diagnosis and treatment of systemic lupus erythematosus▼▼▼Click to read the original article to download the AppFor medical professionals onlyOn the relationship between SLE and pregnancy Systemic lupus erythematosus (SLE) is an autoimmune inflammatory connective tissue disease involving multiple organs in young women.
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Xu Pinglong's team at Zhejiang University reveals the function and mechanism of blood sugar regulation and antiviral innate immunity Cell Press dialogue scientists
Time of Update: 2023-01-01
Life SciencesLife scienceOn November 15, 2022, Xu Pinglong's laboratory at the Institute of Life Sciences of Zhejiang University published a research paper titled "AMPK directly phosphorylates TBK1 to
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Plant Cell: A core effector protein that inhibits host immunity!
Time of Update: 2023-01-01
Recently, the Panagiotis F Sarris research group at the University of Crete in Greece published an online publication titled The host exocyst complex is targeted by a conserved bacterial type-III online at The Plant Cell Effector that promotes virulence's research paper, found in XanthomonasAbility to attack the host exocapsule complex and disrupt host immunity.
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Nat Genet Zhang Zhao's group reveals the new role of reversal colons in activating the innate immune system to resist the invasion of foreign viruses for a long time
Time of Update: 2023-01-01
Reverse locons are present in almost all eukaryotes and are extremely abundant in the genome. In humans, reversers make up up to 38% of the genome. After the activation of the reverse locon, the mRNA,
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How should immunosuppressants be used for patients with these 3 special conditions?
Time of Update: 2023-01-01
Curriculum 2022,Am J Kidney Dis. 80(3):393-405In order to better provide you with interesting, useful and attitude content, the Rheumatology and Immunology Channel of the Medical Community welcomes everyone to complete the following research with your fingers, it only takes two minutes!MMF is metabolized in the liver, anddose reduction should be considered in case of a severe decrease in renal function.
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During an acute attack of gout, these drugs can be chosen!
Time of Update: 2023-01-01
👇 Download the Decision Assistant App, the guide is free at any time ~▼▼▼Click to read the original article to download the App *For medical professionals onlyFor more ways to diagnose and treat gout, see what the guide says!
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Colchicine for liver and kidney damage, so that it is safe to adjust the dose!
Time of Update: 2023-01-01
Second, adult liver injury ▍ 1, gout attack to prevent gout attack: For the prevention of gout attacks in patients with mild to moderate hepatic impairment, the recommended dose adjustment is not required, but patients should be closely monitored for adverse effects after colchicine use.
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How is Sjogren's syndrome diagnosed? Don't forget this check!
Time of Update: 2023-01-01
OneTear secretion test (Schirmer test)Operation procedure: in a quiet and dark light environment, the standard Schirmer filter paper is bent at the scale, gently placed into the temporal edge of the lower eyelid of the subject, the patient is instructed to close his eyes gently, retain the filter paper for 5min, take out the filter paper after 5min, and measure the length of the test strip being wetted.
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Express significantly improved psoriasis symptoms with positive Phase 2 clinical results of TYK2 inhibitors
Time of Update: 2023-01-01
▲If you have any business needs, please press and hold to scan the QR code above, or▎WuXi AppTec Content Team Editor Not long ago, Nimbus Therapeutics released positive top-line results of a selective tyrosine kinase 2 (TYK2) allosteric inhibitor in a Phase 2b clinical trial.
