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Evidence-based medicine, rational use of medicine
Allopurinol and its metabolite oxypurinol can inhibit xanthine oxidase and prevent hypoxanthine and xanthine metabolism to uric acid, thereby reducing the production
of uric acid.
Allopurinol is commonly used clinically in the treatment of gout, particularly in patients
who cannot tolerate oral therapy or who have chronic or recurrent attacks.
So what are the points to pay attention to when using allopurinol? Let's take a look with Jie Xiaoyao~
To treat gout, how to determine the dosage?
- Tablets: The initial dose is 50mg once, 1-2 times a day, and can be increased by 50-100mg per week to 200-300mg a day, divided into 2-3 times
.
Blood and uric acid levels are measured every 2 weeks, and if they have reached normal levels, they do not increase, and if they are still high, they can be increased
.
However, the maximum amount per day should not be greater than 600 mg [1-2].
- Sustained-release tablets: the general average dose is 250mg per day, which can be adjusted as appropriate [3].
- Sustained-release capsules: 250 mg once a day [4].
Severe liver and kidney insufficiency are banned!
(1) Adult kidney injury: patients with renal impairment should reduce the dose; Patients with renal insufficiency should adjust the dose according to creatinine clearance; Patients with severe renal insufficiency are banned
.
(2) Adult liver injury: patients with liver damage should reduce the dose; Patients with severe hepatic insufficiency are banned
.
(3) Children: the usual amount for the treatment of secondary hyperuricemia: 50mg each time under 6 years old, 1-3 times a day; 6-10 years old, 100mg once, 1-3 times
a day.
The dose can be adjusted as appropriate [1-2].
(4) Elderly: The elderly should be cautious and should reduce the daily dosage
.
Start small doses and increase them gradually
(1) This product cannot control the acute inflammatory symptoms of gouty arthritis and cannot be used
as an anti-inflammatory drug.
Because this product promotes the re-dissolution of uric acid crystals, it can again induce and aggravate the acute symptoms
of arthritis.
(2) This product must be applied after the acute inflammatory symptoms of gouty arthritis disappear (generally about two weeks after the attack).
(3) Drink plenty of water during the medication, and make the urine neutral or alkaline to excrete
diuretic acid.
(4) This product is used for blood uric acid and 24-hour uric acid excess, or tophi, or urinary stones and uric acid excretion drugs should not be used
.
(5) This product must start from a small dose, gradually increase to the effective amount to maintain normal blood uric acid and uric acid levels, and then gradually reduce the amount, and maintain a longer time with the minimum effective amount
.
(6) Combined with uricic acid drugs can enhance the efficacy
.
It should not be taken
with iron.
(7) Before and during medication, regularly check blood uric acid and 24-hour uric acid levels as the basis
for adjusting drug doses.
More popular drugs in Corey, where to learn?
Can I take allopurinol during an acute attack of gout?
What are the most common side effects of taking this product?
Which drugs interact with allopurinol?
References: [1] Drug information: allopurinol tablets, World Trade Tianji Pharmaceutical (Jiangsu) Co.
, Ltd.
, Sinopharm H20033683; 2013/12/06
。 [2] Drug information: allopurinol tablets, Guangdong Pidi Pharmaceutical Co.
, Ltd.
, Sinopharm H44021368; 2015/11/30
。 [3] Drug information: allopurinol sustained-release tablets, Hainan Puli Pharmaceutical Co.
, Ltd.
, Sinopharm H20041743
.
[4] Drug information: allopurinol sustained-release capsules, Heilongjiang Aolidanide Pharmaceutical Co.
, Ltd.
, Sinopharm H20041338
.
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