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When is lupus started with immunosuppressants? How to choose 7 drugs?
Time of Update: 2023-01-06
Download the decision assistant App, the guide is free at any time ~ References: [1]2020 Chinese Systemic Lupus Erythematosus Diagnosis and Treatment Guide ▼▼▼Click to read the original article to download the AppImmunosuppressants are recommended in patients with systemic lupus erythematosus (SLE) who do not respond well to hormonal plus hydroxychloroquine, or who are unable to adjust the dose of the hormone below a relatively safe dose.
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Blood(IF=25) He Sultan's team at the Chinese Academy of Medical Sciences discovered a novel RIPK1 inhibitor that reduces graft-versus-host disease through a non-immune mechanism
Time of Update: 2023-01-06
IFN-γ enhances the binding of RIPK1 to JAK1 and activates STAT1 in IECs (Blood Source) It is worth noting that the study found a selective and potent RIPK1 inhibitor (Zharp1-211) that significantly reduced the expression of JAK/STAT1-mediated chemokines and MHC class II molecules in IECs, restored intestinal homeostasis, and did not affect graft anti-leukemia ( Graft-versus-leukemia, GVL) effect in case of blocking GVHD.
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Highlights sneak peek! The Chinese expert consensus on the diagnosis and treatment of dermatomyositis has been released!
Time of Update: 2023-01-06
Recently, the "Chinese Expert Consensus on the Diagnosis and Treatment of Dermatomyositis in Adults" was officially published online in the Chinese Journal of Dermatology, answering these key clinical questions.
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Highlights sneak peek! The Chinese expert consensus on the diagnosis and treatment of dermatomyositis has been released!
Time of Update: 2023-01-06
Recently, the "Chinese Expert Consensus on the Diagnosis and Treatment of Dermatomyositis in Adults" was officially published online in the Chinese Journal of Dermatology, answering these key clinical questions.
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Personalized treatment for rheumatoid arthritis, the latest research of Nature sub-journal to help!
Time of Update: 2023-01-06
1038/s41467-022-33785-wClick "Read Original" to get more clinical dry goods*For reference by medical professionals only, although symptoms are similar between cases of RA, response to treatment varies greatlyExecutive SummaryOn October 20, a study published in Nature Communications deeply analyzed the molecular regulatory mechanisms of rheumatoid arthritis (RA) and found that there are huge differences in the molecular regulatory functions of different cell subtypes involved in RA.
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Nature sub-issue: A new mechanism to fight immune aging! Scientists have found that antigen-presenting cells actively present telomeres to T cells, helping T cells prolong their life
Time of Update: 2023-01-06
In the immune memory stage, Tel+T significantly prolongs the survival of miceIn summary, Professor Alessio Lanna's research team found that APCs "selflessly" their telomeres to T cells, thereby helping T cells "survive", enhance immune responses and stabilize long-term immune memory.
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Magical! Genes associated with lupus protect against severe COVID-19 infection!
Time of Update: 2023-01-06
Click "Read Original" to get more clinical dry goods*For medical professionals onlyWhat's going on here?Executive SummaryOn November 3, 2022, a study published in PLOS Genetics by David Morris and Timothy Vyse of King's College London, UK, showed that genetic susceptibility to systemic lupus erythematosus (SLE) may have a protective effect against severe COVID-19 infection.
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Magical! Genes associated with lupus protect against severe COVID-19 infection!
Time of Update: 2023-01-06
Click "Read Original" to get more clinical dry goods*For medical professionals onlyWhat's going on here?Executive SummaryOn November 3, 2022, a study published in PLOS Genetics by David Morris and Timothy Vyse of King's College London, UK, showed that genetic susceptibility to systemic lupus erythematosus (SLE) may have a protective effect against severe COVID-19 infection.
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8 Cell/Nature/Science Gao Fu, He Dayi, Yuan Guoyong and other teams revealed the potential mechanism of Omicron's antibody escape and rapid spread
Time of Update: 2023-01-06
iNatureThe coronavirus disease 2019 pandemic continues to affect people around the world. The rapid development and deployment of effective vaccines, as well as monoclonal antibody therapies, from the
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What's new in RA? What is updated in the EULAR guidelines? One article mastered!
Time of Update: 2023-01-06
Come to the "doctor's station" and take a look 👇Safety of bDMARDs versus tsDMARDsAlarge study (Figure 2) including data from the registries of RA patients in 16 countries found no significant difference in discontinuation rates due to adverse effects between csDMARDs, TNF-α inhibitors, and JAK inhibitors.
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From immunoablation to immunomodulatory therapy, novel systemic lupus erythematosus cell therapies are moving towards the clinic with the latest review
Time of Update: 2023-01-06
One approach is to induce direct/indirect Treg cell expansion through immunosuppressants, for example, sirolimus alone or in combination with other drugs, which has been shown to be effective in improving disease activity in multiple clinical trials, and studies have shown significant reductions in prednisone doses in SLE patients treated with sirolimus.
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From immunoablation to immunomodulatory therapy, novel systemic lupus erythematosus cell therapies are moving towards the clinic with the latest review
Time of Update: 2023-01-06
One approach is to induce direct/indirect Treg cell expansion through immunosuppressants, for example, sirolimus alone or in combination with other drugs, which has been shown to be effective in improving disease activity in multiple clinical trials, and studies have shown significant reductions in prednisone doses in SLE patients treated with sirolimus.
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CMI(IF=22) The team of Xiaoyong Man of Zhejiang University revealed that the epidermal immune microenvironment plays an important role in the development of psoriasis
Time of Update: 2023-01-06
Original link: style="margin-right: auto;margin-left: auto;outline: 0px;width: 30px;display: inline-block;">—END—The content is [iNature]The skin acts as the first battleground for the host, as well as a physical and immune barrier, involved in defending against exogenous pathogens and physical dangers, and maintaining tissue homeostasis.
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What does the ACR/EULAR RA mitigation standard update optimize? Research Express
Time of Update: 2023-01-06
0 is more consistent with SDAI or CDAI mitigation standards Among the 2048 trial participants included in the study (1101 with early RA and 947 with confirmed RA), after six months of treatment, the response rate using Boolean 2.
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Immunity ATP binds to the transporter ABCC1 to transport the immunotransmitter cGAMP outside the cell
Time of Update: 2023-01-06
Stetson's research group from the University of Washington published a report on Immunity titled ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP In the paper, it was found that ATP-binding transporter ABCC1 is an important factor in transporting cGAMP out of the cell.
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2022ACR ends today Lupus nephritis has attracted much attention, and various research results have exploded, and this article will take you to unlock the most informative content!
Time of Update: 2023-01-06
For medical professionals onlyThe ACR Annual Meeting was directly on the spot, comprehensively explaining the heavy data and new explorations in the field of lupus nephritis. As an authoritative acade
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How is xerostomia diagnosed, treated and prevented? 2022 ACR Essence Express There are benefits at the end of the article
Time of Update: 2023-01-06
Figure 1: Dry oral mucosa/erythema care for patients with dry mouth should focus on the complications of xerostomia, particularly those with severe saliva flow deficit.
Figure 1: Dry oral mucosa/erythema care for patients with dry mouth should focus on the complications of xerostomia, particularly those with severe saliva flow deficit.
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Express Potential "first-in-class" therapy! More than $100 million to help bifunctional antibodies enter Phase 3 clinical trials
Time of Update: 2023-01-06
The funds raised will be used primarily to advance its lead project, obexelimab, a bifunctional antibody into a global Phase 3 clinical trial to review the efficacy and safety of this drug in the treatment of immunoglobulin G4-related disease (IgG4-RD).
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The latest paper of the 2022 Nobel Prize winner: targeting sugar molecules on the surface of cancer cells to enhance the effect of immunotherapy
Time of Update: 2023-01-06
Link to the paper: style="color: rgb(136, 136, 136);font-size: 12px;" _mstmutation="1" _istranslated="1"> open reprint Welcome to Moments and WeChat groups SourceChina Biotechnology NetworkAs we all know, the immune system is the body's defense network, with various abilities to remove abnormal cells.
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The Immunity TCR-Engine can be used to design synthetic TCRs with enhanced potency and specificity
Time of Update: 2023-01-06
Written by | T cells genetically modified to express TCR that recognize tumor-associated antigens are helpful for cancer immunotherapy, but usually because of the risk of cross-reactivity with off-tar
