-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
*For medical professionals only
What's going on here?
Executive Summary
On November 3, 2022, a study published in PLOS Genetics by David Morris and Timothy Vyse of King's College London, UK, showed that genetic susceptibility to systemic lupus erythematosus (SLE) may have a protective effect
against severe COVID-19 infection.
Study screenshots
status quo
against viral infection outcomes.
Genes associated with severe COVID-19 are associated
with genes with SLE.
To locate relevant genes and gain insight into shared genetic effects, the researchers compared the genetics of severe COVID-19 to the genetics of SLE using multiple analyses, including a method
that could focus on specific regions of the genome.
The authors then accessed data on genes and genome structures obtained from several biomedical databases to understand the biology
of shared genetics.
conclusion
of three European GWAS.
The researchers found:
- There is a shared genetic effect
between the autoimmune disease SLE and the clinical consequences of COVID-19.
The loci with the most shared association evidence (TYK2) are involved in the production of interferon, a process important for response to viral infection and known dysregulation
in SLE patients. - In trying to uncover the mechanisms behind these relationships, it is clear that the functional effects of risk and protective genotypes are complex
.
Future research will require a good understanding of the genetic relationship
between COVID-19 and other diseases.
prospect
Large-scale genetic studies of COVID-19 and SLE have made this exciting result possible and opened the door
for us to understand how the biology of the immune system calibrates to protect us from viruses and other infectious agents.
Click "Read Original" to get more clinical dry goods
