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    Home > Active Ingredient News > Immunology News > Does systemic lupus erythematosus affect pregnancy attempts?

    Does systemic lupus erythematosus affect pregnancy attempts?

    • Last Update: 2023-01-06
    • Source: Internet
    • Author: User
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    For medical professionals only



    On the relationship between SLE and pregnancy


     

    Systemic lupus erythematosus (SLE) is an autoimmune inflammatory connective tissue disease
    involving multiple organs in young women.


    The cause of systemic lupus erythematosus is currently unknown
    .
    Possible factors include: genetic predisposition, estrogen, environmental factors (ultraviolet light, drugs, smoking, etc.
    ), viral infections, etc
    .


    One

    How is systemic lupus erythematosus (SLE) diagnosed?


    The diagnosis of suspected SLE is recommended using the 2012 International Lupus Research Clinical Collaborative Group (SLICC) or the 2019 EULAR/ACR SLE classification criteria
    .

    EULAR/ACR 2019 SLE classification standard


    Two

    How are peripregnant patients managed?


    1.
    For women of childbearing age with SLE, if the condition is stable for at least 6 months, there is no damage to important organs, and the potentially teratogenic drugs are discontinued to a safe enough time, pregnancy can be considered
    .


    2.
    If you plan to become pregnant, you should consult with rheumatology and immunology and obstetricians and gynecologists before pregnancy and conduct relevant assessments
    .


    3.
    For pregnant SLE patients, SLE disease activity and fetal growth and development should be closely
    monitored.


    4.
    If there are no contraindications, it is recommended to take hydroxychloroquine throughout pregnancy, and if there is disease activity, you can consider the use of hormones and azathioprine to control the disease
    .


    5.
    The use of azathioprine during pregnancy in SLE patients will not cause fetal teratogenicity, and can reduce the risk of disease recurrence and improve fetal outcomes
    .


    6.
    Hydroxychloroquine, hormones, azathioprine, cyclosporine A and tacrolimus can be used to prevent or control SLE recurrence during pregnancy, but mycophenolate mofetil, cyclophosphamide, leflunomide and methotrexate should not be used
    .


    Patients with SLE perigestational capacity is not affected by disease, but there is a risk of poor pregnancy outcome and planned pregnancy
    should be on medical advice.


    How is SLE patient selected?

    How should organs and systems be affected?

    For more information on the diagnosis and treatment guidelines of systemic lupus erythematosus【Clinical Decision Making App】


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    References:

    [1] 2020 Chinese guidelines for the diagnosis and treatment of systemic lupus erythematosus


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