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Science Advances Sun Yat-sen University's Wang Zhi team found that T cell metabolic reprogramming regulates the progression of autoimmune diseases and their therapeutic significance
Time of Update: 2022-10-13
The study found that phosphatidylinositol 3-kinase (PI3K) interacting protein 1 (Pik3ip1) is a newly discovered negative immunomodulator that is significantly downregulated in several major autoimmune diseases through a previously unidentified mechanism mediated by the interleukin-21/p38 mitogen-activated protein kinase/a lysin and metalloproteinase-17 (ADAM17) pathways.
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Nat Metab γ-GABA (GAB) functionally regulates T cell inflammation through bioenergy and signaling
Time of Update: 2022-10-13
Overall, our results suggest that GAB's autonomic regulation of CD4+ T cells in the immune system as a traditional central neurotransmitter is bidirectional, relying on ABAT-mediated mitochondrial chimeralization and GABAaR regulated signaling responses (Figure 2).
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JAMA: A gout attack or a heart attack alarm! Data from more than 60,000 patients with gout show that gout attacks are associated with an increased risk of cardiovascular events in the short term
Time of Update: 2022-10-13
Association between cardiovascular events and pre-event gout episodes (nest case-control study)The self-controlled case series was observed for up to 720 days, and overall, the incidence of cardiovascular events after the gout attack gradually decreased.
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Mol Cell │A new mechanism of antiviral infection independent of the innate immune pathway
Time of Update: 2022-10-13
It specifically inhibits the replication of chikungunya virus (CHIKV) and its close relative Aryalian virus (ONNV) without affecting the replication of other alpha viruses, and confirms that ALPHA can function independently of IFN to prevent viral RNA replication by directly binding to viral genomic RNA, suggesting that ALPHA and other potential lncRNAs can mediate atypical antiviral immune responses against specific viruses.
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The diagnosis and treatment of aortitis, read this article is enough
Time of Update: 2022-10-13
*For medical professionals onlyTreatment of polyarteritis has trade-offs in the treatment of polyarteritisRecently, the 9th International Forum on Rheumatism Immunization in Children and the 15th Nati
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Nature Sub-Journal Su Wenru/Zheng Yingfeng/Liu Xialin of Sun Yat-sen University discovered potential therapeutic targets for uveitis
Time of Update: 2022-10-13
1038/s41467-022-33502-7—END—The content is [iNature]iNatureUveitis is a serious autoimmune disease and a common cause of blindness; However, its individual cell dynamics and pathogenesis are still poorly understood.
1038/s41467-022-33502-7—END—The content is [iNature]iNatureUveitis is a serious autoimmune disease and a common cause of blindness; However, its individual cell dynamics and pathogenesis are still poorly understood.
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When RA encounters LTBI, how to break through the treatment bottleneck?
Time of Update: 2022-10-13
*For medical professionals onlyIf csDARD and bDMARD treatment is ineffective in RA patients with LTBI, can tsDMARD bring improvement?Rheumatoid arthritis (RA) is one of the common systemic rheumatism diseases in China, and the prolonged course of the disease and the high disability of the disease make patients miserable, but also bring a heavy burden to families and society [1].
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Preparative Chiral Separation of Hydroxychloroquine Using Supercritical Fluid Chromatography
Time of Update: 2022-10-12
1% DEA)/CO2 at a flow rate of 4 mL/min and detection at 220 nm : Preparative SFC Chromatography of Enantiomer Separation and Detection of 1 g of HCQ on Enantiocel C2-5 Column (3 × 25 cm) Using 40% Methanol (0.
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Preparative Chiral Separation of Hydroxychloroquine Using Supercritical Fluid Chromatography
Time of Update: 2022-10-12
1% DEA)/CO2 at a flow rate of 4 mL/min and detection at 220 nm : Preparative SFC Chromatography of Enantiomer Separation and Detection of 1 g of HCQ on Enantiocel C2-5 Column (3 × 25 cm) Using 40% Methanol (0.
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Efficacy of hydroxychloroquine in improving pregnancy outcomes in women with systemic lupus erythematosus and antiphospholipid syndrome
Time of Update: 2022-10-12
Here, a case of systemic lupus erythematosus (SLE) and aspirin-heparin resistant APS is reported, successfully treated with HCQ in addition to the patient's existing treatments.
Here, a case of systemic lupus erythematosus (SLE) and aspirin-heparin resistant APS is reported, successfully treated with HCQ in addition to the patient's existing treatments.
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Corning Jerry KN019 Phase II study on the treatment of rheumatoid arthritis reached the primary endpoint of the press release
Time of Update: 2022-10-12
HK) announced that its self-developed phase II clinical study of recombinant human CTLA-4 variant Fc fusion protein KN019 for the treatment of hypermethotrexate (MTX) inadequately responsive active rheumatoid arthritis (study number: KN019-201) reached the main research endpoint.
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Rheumatology: Metformin alleviates osteoarthritis by targeting chondrocytes, synovial macrophages and adipocytes
Time of Update: 2022-10-12
1093/rheumatology/ keac467 Objective: To investigate the therapeutic effect and mechanism of metformin on knee osteoarthritis (OA) in normal diet (ND) mice and high-fat diet (HFD)-induced obese mice .
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J Invest Dermatol: Lenabasum is effective in treating dermatomyositis
Time of Update: 2022-10-12
A single-center, double-blind, randomized, placebo-controlled, Phase 2 study published in J Invest Dermatol was designed to evaluate the safety and efficacy of Lenabasum in patients with refractory dermatomyositis.
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Does the presence of rheumatoid nodules mean that the condition is worse?
Time of Update: 2022-10-12
So if there is a rheumatoid nodule, but there are no other symptoms, do not worry too much, you can continue to use the previous drug, observe for a period of time, if the nodule does not subside on its own, or other uncomfortable conditions in the body, and then go to the rheumatology department of the hospital for examination, according to the doctor's diagnosis to adjust the medication, symptomatic treatment, you can control the condition of rheumatoid disease.
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Rheumatology: Metformin alleviates osteoarthritis by targeting chondrocytes, synovial macrophages and adipocytes
Time of Update: 2022-10-12
1093/rheumatology/ keac467 Objective: To investigate the therapeutic effect and mechanism of metformin on knee osteoarthritis (OA) in normal diet (ND) mice and high-fat diet (HFD)-induced obese mice .
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NEJM: Intravenous immunoglobulin Octagam for dermatomyositis (ProDEMM study)
Time of Update: 2022-10-12
N Engl J Med 2022; 387:1264-1278 In 2021, the US FDA approved the marketing of human intravenous immunoglobulin Octagam 10% for the treatment of adult dermatomyositis.
N Engl J Med 2022; 387:1264-1278 In 2021, the US FDA approved the marketing of human intravenous immunoglobulin Octagam 10% for the treatment of adult dermatomyositis.
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Exercise for Rheumatoid Arthritis
Time of Update: 2022-10-12
Exercise not only relieves pain, effectively improves muscle strength and endurance, but also increases joint range of motion to promote venous and lymphatic return, thereby helping to eliminate joint swelling .
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Exercise for Rheumatoid Arthritis
Time of Update: 2022-10-12
Exercise not only relieves pain, effectively improves muscle strength and endurance, but also increases joint range of motion to promote venous and lymphatic return, thereby helping to eliminate joint swelling .
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Behind the FDA's approval of the first related oral therapy voclosporin, where is the future innovation path for lupus nephritis?
Time of Update: 2022-10-12
Although patient and kidney survival rates have improved considerably compared to the last century, due to the use of steroids and other immunosuppressants, only 20-30% of patients achieve complete renal remission (CRR), defined as proteinuria ≤0.
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Int J Dermatol: Patients with purulent hidradenitis are at increased risk of developing inflammatory arthritis
Time of Update: 2022-10-12
The results showed an increased incidence of rheumatoid arthritis (RA), ankylosing spondylitis (AS), and psoriatic arthritis (PsA) in HS patients compared to the general population (the prevalence of RA in the HS population was 0-4.
