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Lack of sleep is associated with an increased risk of lupus!
Time of Update: 2022-10-14
The study detected an additive interaction between low duration of sleep and high body pain (SF-367 to 8 hours) was associated with an increased risk of SLE (adjusted HR=2.
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Progress has been made in the study of fish-specific antiviral immune regulatory mechanisms
Time of Update: 2022-10-14
FTRCA1 simultaneously obtained E3 enzyme activity and RNA binding activity to regulate interferon carp antiviral immune responseFigure 2: Crucian carp HERC7 targets RLR signaling pathway molecules at the protein level and mRNA level to regulate the antiviral immune response of interferon carpSource: Institute of Hydrobiology, Chinese Academy of SciencesPrevious studies have suggested that phenotypic differences between and within species stem from differences in gene expression regulation.
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Retirement does not fade, how to let the elderly RA patients get rid of the disease and return to the art hall?
Time of Update: 2022-10-14
Commonly used drugs for RA treatment include glucocorticoids, nonsteroidal anti-inflammatory drugs (NSAIDs), traditional synthetic disease-improving antirheumatic drugs (csDMARD), and targeted drugs (b/tsDMARD) and proprietary Chinese medicines, which vary in efficacy and safety risks in elderly patients with RA 。 Eramod is a novel small molecule DMARD that has been shown in various clinical studies, whether single-agent or combination, to significantly alleviate clinical symptoms, reduce disease activity, improve bone metabolism in elderly patients with RA [5-10].
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When AS encounters tumors, how to choose biological agents to take into account the overall situation?
Time of Update: 2022-10-14
*For medical professionals onlyIL-17A inhibitors or AS co-existing tumor patients are preferred for treatment.
*For medical professionals onlyIL-17A inhibitors or AS co-existing tumor patients are preferred for treatment.
IL-17A inhibitors or AS co-existing tumor patients are preferred for treatment.
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Express Rapid-acting treatment of allergic reactions, sublingual administration of epinephrine clinical top line data is eye-catching
Time of Update: 2022-10-14
The results showed that AQST-109 achieved a significantly faster median time to maximum plasma drug concentration (Tmax) than epinephrine auto-injectors and ordinary intramuscular epinephrine, and repeated administration provided significantly higher blood concentrations.
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How is hydroxychloroquine used for 2 years, how is cardiotoxicity? The latest research gives the answer
Time of Update: 2022-10-14
Figure 1: Screenshot of the study The latest study shows that the use of hydroxychloroquine is not associated with the development of long Q-T interval syndrome (LQTS) in patients with RA, after which the risk increases, and after 5 years of use, this risk becomes significant.
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How is Sjogren's nerves treated symptomatically? An article to understand the symptoms, diagnosis, treatment of the latest review
Time of Update: 2022-10-14
Table 1 Clinical manifestations of the pSS nervous system Evaluation and diagnosis Diagnosis of pss-related peripheral nervous system manifestations should be combined with clinical presentation and laboratory tests, and patients should be evaluated for sensory, motor, and autonomic symptoms.
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What should be paid attention to in patients with rheumatic diseases around pregnancy?
Time of Update: 2022-10-14
Drugs to be avoided in women with rheumatism peri-pregnancyDrugs that may cause fetal malformations should be avoided during the peri-gestational period, and rheumatology immunologists should plan their medications according to the patient's condition and pregnancy plan (Table 1).
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The classification of auto-inflammatory diseases is complicated, Professor Li Caifeng clarified in an article!
Time of Update: 2022-10-14
Interferon pathway disease Common clinical features of interferon pathway disease are:Cutaneous vascular manifestations (erythema nodosum, frostbite-like rash, reticulated blue spots, gangrene/ulceration of the extremities, vasopathic changes);Adiponitis, lipodystrophy;manifestations of the central nervous system (basal ganglion calcification, leukodyma);pulmonary involvement (interstitial lung disease, pulmonary fibrosis);Muscular-muscular manifestations (contractures, non-invasive arthritis, myositis).
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Nat Rev Immunol(IF=109) Pengfei Wang/Shibo Jiang published a review of a wide range of antibodies to the new crown virus and other human coronaviruses
Time of Update: 2022-10-14
Informational message:—END—Content is [iNature]iNatureSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recently emerging pathogenic human coronavirus that belongs to the sarbecavirus lineage of the genus β coronavirus.
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Cell Res takes the progress again! Based on artificial intelligence, Cao Xuetao's team quickly generated a wide range of reactive antibodies against the new crown virus and variants
Time of Update: 2022-10-14
The research makes use of the advantages of artificial intelligence and big data to independently develop and design an artificial intelligence algorithm that can screen the specific antibodies of the new crown virus and its variants in high throughput: XBCR-net.
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A picture to read: NICE gout management guidelines recommended summary of the guidelines consensus
Time of Update: 2022-10-14
Recommended Reading: 2022 New Gout Guidelines, Diet, Acute and Long-term Management | Guide consensus On August 30, the journal BMJ (Impact Factor 93.
Recommended Reading: 2022 New Gout Guidelines, Diet, Acute and Long-term Management | Guide consensus On August 30, the journal BMJ (Impact Factor 93.
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Rituximab induction therapy for systemic lupus erythematosus works, so what about as maintenance therapy? Research courier
Time of Update: 2022-10-14
To compare the efficacy and safety of RTX and traditional ISAs in maintenance therapy for patients with relapsed or refractory SLE after RTX-induced remission, and to explore the predictors of SLE recurrence, Dr. Chen Xiaotou and others at the Second Affiliated Hospital of Zhejiang University School of Medicine conducted a prospective study recently published in Rheumatology (Oxford) (Impact Factor 7.
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This kind of vasculitis delay diagnosis mortality rate is high, diagnostic ideas please put away ...
Time of Update: 2022-10-14
* For medical professionals to read and reference, it is another case that makes people "stupid and unclear"Case profileIn women 60+ years of age, there is no obvious trigger for bilateral lower extremity papulative purpura rash[1].
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Monitoring and contraindications to sulfasalazine, summarized in one table
Time of Update: 2022-10-14
This paper focuses on the pharmacological effects of SSZ in rheumatic diseases, clinical indications and dosage, adverse drug reactions and monitoring.
This paper focuses on the pharmacological effects of SSZ in rheumatic diseases, clinical indications and dosage, adverse drug reactions and monitoring.
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Immunity view of liver macrophages when healthy and sick
Time of Update: 2022-10-14
However, studies have shown that certain key genes involved in iron and cholesterol homeostasis in the human liver are expressed only by specific cells, suggesting that hepatocytes, LSECs, stellate cells, and KCs worked together as an integrated niche throughout evolution.
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Nature Sub-Journal Luo Zhong/Li Menghuan of Chongqing University develops new nano-agonists that enhance the T-cell-mediated anti-tumor immune response
Time of Update: 2022-10-13
On September 28, 2022, Chongqing University Luo Zhong and Li Menghuan published a research paper entitled "A protein-based cGAS-STING nanoagonist enhances T cell-mediated anti-tumor immune responses" at Nature Communications, which reports a bovine-based serum albumin (BSA)/ A nanoagonist of ferritin, which combines manganese (II) ions and β-lapachone, it synergistically activates cGAS-STING signaling in dendritic cells (DCs), triggering powerful adaptive anti-tumor immunity.
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Does methotrexate increase the risk of melanoma? The latest research gives the answer
Time of Update: 2022-10-13
Observational studies have reported an association between melanoma and low-dose methotrexate, however, there is still a lack of high-quality evidence-based medical evidence for this problem due to a number of unadjusted melanoma risk factors (UV exposure and personal and family history of melanoma).
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Immunity Crohn's disease patient T cells respond to intestinal bacteria shift
Time of Update: 2022-10-13
Written by | In a fish with countless microorganisms in the human gut, in healthy people, the immune system exhibits immune tolerance to these symbiotic microorganisms, while in patients with enteriti
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Mol Cell │A new mechanism of antiviral infection independent of the innate immune pathway
Time of Update: 2022-10-13
It specifically inhibits the replication of chikungunya virus (CHIKV) and its close relative Aryalian virus (ONNV) without affecting the replication of other alpha viruses, and confirms that ALPHA can function independently of IFN to prevent viral RNA replication by directly binding to viral genomic RNA, suggesting that ALPHA and other potential lncRNAs can mediate atypical antiviral immune responses against specific viruses.
