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Clinical information, 1s reach
▎Clinical Questions: How is the duration of chronic low sleep related to the risk of developing systemic lupus erythematosus (SLE)? Study using
the Nurses' Health Study (NHS) (1986-2016) and NHSII (1989-2017) cohort to investigate whether sleep deprivation is associated
with the risk of SLE occurrence.
The NHS (1986-2014) and NHSII (1989-2009) cohorts reported average sleep time over a 24-hour period
.
Lifestyle, exposure and medical information are collected
in a biennial questionnaire.
Adjusted Cox regression analysis simulates the correlation between cumulative mean sleep duration (categorical variable) and SLE events
.
It studied the interaction
between sleep duration and shifts, body pain (SF-36) and depression.
During follow-up 4246094 years, 186072 women were included in the study, including a total of 187 patients with SLE
.
▎Main findings:
Duration of chronic low sleep (≤5 h/night vs reference >7 to 8 hours) was associated with an increased risk of SLE (adjusted HR=2.
47, 95% CI 1.
29 to 4.
75), persisted
after 4 years of analysis lag (adjusted HR=3.
14, 95% CI 1.
57 to 6.
29), and adjusted shift, body pain, and depression (adjusted HR=2.
13, 95% CI 1.
11 to 4.
10).
The study detected an additive interaction between low duration of sleep and high body pain (SF-36<75) in patients with risk factors compared with no risk factors, with an attributable ratio (AP) of 64% (95% CI 40% to 87%) and HR of 2.
97 (95% CI 1.
86 to 4.
75)
in patients with SLE.
There was an interaction between low sleep duration and depression, with an AP of 68% (95% CI 49% to 88%) and HR of 2.
82 (95% CI 1.
64 to 4.
85)
in patients with SLE.
of adequate sleep in disease prevention.
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