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Preparative Chiral Separation of Hydroxychloroquine Using Supercritical Fluid Chromatography

 Last Update: 2022-10-12
 Source: Internet
 Author: User

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Hydroxychloroquine (HCQ) is widely used as a racemic sulfate in the treatment of malaria, rheumatoid arthritis and systemic lupus erythematosus

To optimize the therapeutic value of a drug, it is necessary to determine whether an enantiomer has lower therapeutic value and/or significant adverse side effects

experiment:

Analytical SFC chromatogram of the HCQ enantiomer on an Enantiocel C2-5 column (0.

Preparative SFC Chromatography of Enantiomer Separation and Detection of 1 g of HCQ on Enantiocel C2-5 Column (3 × 25 cm) Using 40% Methanol (0.

Each enantiomer of HCQ collected on an Enantiocel C2-5 column (0.

In conclusion, a robust supercritical chromatography (SFC) method using an Enantiocel C2-5 column was developed for the multigram separation of the enantiomers of hydroxychloroquine (HCQ), demonstrating its role as a The use of a scalable technology and the ability to provide quantities of each enantiomer for clinical evaluation

Reference: Wilson LJ, Mi C, Kraml CM.

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