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Cold! Three studies of NEJM/Nature have proved that chloroquine is untreatable in the treatment of COVID-19/SARS-CoV-2!
Time of Update: 2020-07-30
therefore, the researchers concluded that the use of hydroxychloroquine or azithromycin did not improve the clinical condition of patients on the 15th day compared to standard treatment in patients with mild to moderate COVID-19 hospitalizations.
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Semin Arthritis Rheu: The efficacy and safety of cyromos in the treatment of systemic lupus.
Time of Update: 2020-07-30
study assessed the efficacy and safety of SLE by siromos through systematic evaluation and meta-analysis.
include sleight of office in original case reports, case series, observational studies, and clinical trials that report seromos on sLE patient outcomes or safety data.
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Semin Arthritis Rheu: Incidence and prevalence of cytomegaloblastitis and rheumatoid polymyalalygia.
Time of Update: 2020-07-30
this systematic literature review (SLR) is intended to summarize the latest evidence on the incidence and prevalence of GCA and PMR.
the SLR provides the latest estimates of the incidence of GCA and PMR in different populations around the world.
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Lancet: abrocitinib monodrug is used in the treatment of moderate to severe adhesion it.
Time of Update: 2020-07-30
the proportion of patients in the abrocitinib 100 mg group (62/156 vs 9/76) and abrocitinib 200 mg group (96/153 vs 9/76) received an EASI-75 response at the 12th week was significantly higher than that of the placebo group.
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Nature: Discover the most effective SARS-CoV-2 virus neutralizing antibodies!
Time of Update: 2020-07-30
27, 2020 /PRNewswire/ -- Researchers at Columbia University's Irvine Medical Center isolated the most effective SARS-CoV-2 virus neutral antibodies to date from several PATIENTs with COVID-19.
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For the new coronavirus SARS-CoV-2/COVID-19, cell journal's latest research progress at a glance (No. 3)
Time of Update: 2020-07-30
http://photos.!--.s---- July 28, 2020 /--- PRNewswire/ -- Since December 8, 2019, several cases of pneumonia with an unknown cause have been reported in Wuhan, Hubei Province, China. most of the pati
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Semin Arthritis Rheu: Acute respiratory viral infection during rheumatic treatment.
Time of Update: 2020-07-30
study reviewed the incidence and severity of acute respiratory virus adverse events associated with rheumatic therapy.
the study found that certain drugs increase the risk of acute respiratory infections.
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Nat Commun: Revealing how to mobilize immune cells against infection!
Time of Update: 2020-07-30
team found that the structure inside the lymph nodes leaves chemical signals that guide B cells through these complex tissues, like miniature lighthouses that guide safe navigation.
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Cell: China has developed a new mRNA new coronapneumonia vaccine, which can maintain thermal stability in vitro for at least a week.
Time of Update: 2020-07-30
July 27, 2020 /prNewswire --- In a new study, researchers from the Chinese Academy of Military Medical Sciences, Suzhou Aibo Biotech Co., Ltd., the China Food and Drug Research Institute, Tsinghua University and the Institute of Life Almanology of the Institute of Military Medicine reported that an experimental SARS-CoV-2 vaccine based on messenger RNA (mRNA) can cause protective immune responses in non-human primates.
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Sci Rep: A comparison of rheumatoid arthritis in the treatment of rheumatoids with a single drug called leflumit.
Time of Update: 2020-07-30
After 3 months of , there were no significant differences in the activity scores of 28 joint diseases (DAS28), health assessment questionnaire (HAQ), blood sink (ESR) and C-reactive protein (CRP) in the single-drug treatment group and the combined treatment group (P.05).
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Arthritis Rheumatol: Kanamono resistance and safety in sJIA patients.
Time of Update: 2020-07-30
On the 15th day of the , considerable efficacy was observed in two subgroups (aJIA-ACR 50/70/90/100) (fever group: 60.0%/48.6%/37.1%/24.3%; to the 6th month, 17 (24.3%) and 26 (37.1%) fever patients were CRJADAS and CRACR, respectively, compared with 9 (17.3%) and 12 (23.1%) without fever.
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Nature: Longitudinal analysis showed that patients with severe COVID-19 suffered from immune dysfunction.
Time of Update: 2020-07-30
28, 2020 // --- In a new study, researchers at Yale University in the United States found that the differential immune system responses of PATIENTs with COVID-19 help predict who will experience moderate and severe disease consequences.
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J Rheumatol: Comparison of abdominal obesity with the risk of rheumatoid arthritis in ordinary obese women.
Time of Update: 2020-07-30
abdominal obesity is associated with an increased RA risk in young and middle-aged women, especially serotonin-positive RA, but in addition to common obesity, abdominal obesity does not cause RA risk alone.
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NATURE: Vertical analysis, the new crown critical patients of the immune disorder situation is what?
Time of Update: 2020-07-30
after an increase in early cytokines, patients with moderate coVID-19 disease showed a gradual decrease in type 1 (antiviral) and type 3 (antifungal) responses.
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Gout encountertheseative, medication will be more careful!
Time of Update: 2020-07-30
▎ agiotensin II receptor antagonist (ARB) chloratan promotes uric acid excretion by inhibiting the activity of uric acid transporter 1 (URAT1), its uric acid reduction effect is dose-dependent, and by reducing blood uric acid levels to reduce cardiovascular events, can be used for gout or HUA combined hypertension .
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Semin Arthritis Rheu: Craniotomy and extracranial cytomegaloblastthromatisis have similar HLA-DRB1 associations.
Time of Update: 2020-07-30
Similar to cranial GCA, the association is also attributed mainly to hlA-DRB1 x 04:01 allele (19.0% vs 5.3% ;p ,lt;0.01; OR (95% CI) s 4.15 (2.06-8.19), respectively).
cranial and LVV-GCA patients did not show differences in HLA-DRB1 allele.
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JAK inhibitor Rinvoq treatment of specific dermatitis: Phase III clinically showed significant efficacy.
Time of Update: 2020-07-30
Photo Source: At the 16th week, patients treated with 15 mg/30 mg of Rinvoq in two doses compared to placebo, had a significant increase in skin removal rate and itchreduction reduction, with 60% and 73% of patients reaching EASI 75, respectively, compared to 13% of the placebo group.
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Nature: Bat genomes reveal how they carry deadly viruses for 65 million years!
Time of Update: 2020-07-30
Now, the latest genome sequencing of six species across the bat family tree reveals how they have been able to beat the virus over 65 million years.
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Blood: Glucocorticoid induced eosic granules reduction!
Time of Update: 2020-07-30
!----: Live cell tracking shows glucocorticoids to induce bone marrow migration of eosinophils.
in summary, the results of this study show that the reduction of eosinophils induced by glucocorticoids is caused by the bone marrow migration of eosinophils dependent on CXCR4.
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Important research results focus on new advances in the field of peptide drug molecular research!
Time of Update: 2020-07-30
Photo credit: Science Translational Medicine, 2020, doi: 10.1126/scitranslmed.aaz7287 (Science Sub-journal: Using M3mP6 polypeptide high-load nanoparticles is expected to treat heart disease doi: 10.1126/sci In a new study, researchers at the University of Illinois at Chicago have developed a new drug that prevents blood clots and does not increase the risk of bleeding, a common side effect of all platelet drugs.
