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The use of bats to control the mechanisms of viruses in the body may help develop new treatments for diseases such as COVID-19.
Time of Update: 2020-07-31
!--webeditor: "page title" -- Bats are generally thought to be infected with a number of deadly viruses, including Ebola virus, rabies, SARS-CoV-2 virus esage that causes COVID-19 Although humans expe
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Rheumatoid arthritis (RA) new drug! Gilead oral JAK1 inhibitor Jyseleca (filgotinib) is recommended by THE EUROPEAN Union CHMP for approval!
Time of Update: 2020-07-31
July 26, 2020 // Gilead and partner Galapagos NV jointly announced that the European Medicines Agency (EMA) Human Pharmaceutical Products Committee (CHMP) has issued a positive review recommending approval of oral selective JAK1 inhibitors Jyseleca (filgotinib, 200mg and 100mg tablets) is used in adult patients with moderate to severe rheumatoid arthritis (RA) who have inadequate response to anti-rheumosis drugs (DMARD) for one or more diseases.
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Nature sub-journal: In addition to cancer, immunotherapy is expected to benefit patients with this type of lung disease.
Time of Update: 2020-07-31
Professor Wernig said: "This study shows a new treatment that can help improve the condition of patients with pulmonary fibrosis.
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New anti-transplant drugs! Incyte/Novartis Jakafi (Russotinib) Therapeutic steroids difficult to treat chronic grafts anti-host disease Phase III clinical success!
Time of Update: 2020-07-31
24, 2020 // Novartis and partner Incyte recently announced that the evaluation of Jakafi (ruxolitinib, Russotinib) treatment of patients with moderate to severe steroid refractive or hormone-dependent chronic transplantation (GVHD) reached the main endpoint and 2 key secondary endpoints.
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Our scientists have published another Cell paper! The effects of SARS-CoV-2 synaptic protein mutation on viral infection and antigen are analyzed in detail.
Time of Update: 2020-07-31
the authors first tested the infection of the 106 pseudo-viruses in the 293T-hACE2 cell line, and the results showed that 22 pseudo-viruses were classified as lowly infectious (16 natural variants and 6 glycogenized mutants), and the RLU value decreased by 4 to 100 times (Figure 3A), of which 13 counterfeit viruses carried mutations in the RBD region.
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Science Sub-journal: Reprogramming macrophages with CSF-1R inhibitors enhances the effectiveness of radiotherapy treatments for glioblastoma.
Time of Update: 2020-07-31
Joyce and her colleagues also demonstrated that combining radiotherapy with a daily drug that targets macrophages --- a set-stimulating factor-1 receptor (CSF-1R) inhibitor -- can reverse this transition and significantly extend the life of the GBM mouse model.
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NEJM: Anti-SARS-CoV-2 antibodies in patients with mild COVID-19 quickly disappear in two to three months.
Time of Update: 2020-07-31
25, 2020 /pr.----- In a new study, researchers at the University of California, Los Angeles, suggest that antibodies produced by the immune system to fight the new coronavirus SARS-CoV-2 may last only a few months in mild lysis, but that doesn't mean protection is gone, and it doesn't mean an effective vaccine can't be developed.
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mRNA drug therapy: accurate and non-toxic anti-cancer, antiviral drugs.
Time of Update: 2020-07-31
he is coordinating SINTEF's activities with an international project called EXPERT, which is developing a mRNA-based drug to treat the deadly triple-negative breast cancer.
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Breakthrough! Discover new SARS-CoV-2 antibodies that destroy the sting protein!
Time of Update: 2020-07-31
24, 2020 /PRNewswire/ -- Targeted stingproteins may provide an effective treatment for SARS-CoV-2 (COVID-19) and provide valuable structural data for the development of vaccines.
their high-resolution data will also provide valuable structural data for teams developing the SARS-CoV-2 vaccine.
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An experimental treatment may hopefully successfully cure HIV infection.
Time of Update: 2020-07-31
July 27, 2020 // A Brazilian man infected with AIDS has not developed any symptoms of the disease for more than a year after undergoing a high-intensity experimental drug therapy designed to remove la
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Several articles read new advances in the field of "Iron Death"!
Time of Update: 2020-07-31
it is well known that a molecule called glutathione peroxidase 4 (GPX4) reverses this process and thus acts as a lipid antioxidant, with some drugs that target GPX4, but most cancers are still resistant to iron death.
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J Hepatol: Maternal obesity will increase the probability of liver cancer in the offspring, and it can accumulate for generations!
Time of Update: 2020-07-31
In a new study published in the journal Journal of Hepatology, researchers found a microRNA in obese female mice that appears to transmit susceptibility to liver cancer and increase the risk of liver cancer in children and offspring.
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Alert! COVID-19 seriously affects the sexual and reproductive health of young people!
Time of Update: 2020-07-31
26, 2020 /PRNewswire/ -- During the COVID-19 pandemic, limited social distance and access to contraception and abortion care are affecting the sexual and reproductive health of adolescents and young people, according to a new study by researchers at Columbia University's Melman School of Public Health and Rutgers University.
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Science Sub-journal: The replication RNA COVID-19 vaccine triggers a powerful immune response in non-human primates.
Time of Update: 2020-07-31
!--:pagetitle"--25 (UPI) -- --- In a new study, researchers from research institutions such as the University of Washington found that a replication RNA vaccine made with lipid nanoparticle emulsions could produce antibodies against THE COVID-19 coronavirus,, or SARS-CoV-2, after an immunity in mice and non-human primates.
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Why is a plant-based diet essential to the health of the body?
Time of Update: 2020-07-30
!--webeditor: "page title" -- We all know that plant-based diets are good for the health of the body, so is there some scientific basis for this? In this article, the small editor on the compilation o
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Ann Rheum Dis: The safety and efficacy of systemic lupus in children with intravenous bellimumonobresis.
Time of Update: 2020-07-30
The !---- ongoing Phase 2, randomized, placebo-controlled, double-blind study assessed the efficacy, safety, and pharmacokinetics of intravenous bellimuazumab in children with systemic lupus erythematosus (cSLE).
main endpoint: SLE Respondent Index (SRI4) Response Rate (Week 52).
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Semin Arthritis Rheu: Acute respiratory viral infection during rheumatic treatment.
Time of Update: 2020-07-30
study reviewed the incidence and severity of acute respiratory virus adverse events associated with rheumatic therapy.
the study found that certain drugs increase the risk of acute respiratory infections.
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Am J Hematol: Is TAFRO syndrome a subtype of iexclusivecoman multicenter Castleman disease?
Time of Update: 2020-07-30
there was no significant difference in clinical, laboratory, and prognosis characteristics between the TAFRO-iMCD, and the TAFRO-w/op-iMCD group.
iMCD-NOS and TAFRO-iMCD samples are typically characterized by plasma cells and hybrid histology, respectively.
, iMCD can therefore be divided into two different subtypes, iMCD-NOS and TAFRO-iMCD.
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Nat Commun: Revealing how to mobilize immune cells against infection!
Time of Update: 2020-07-30
team found that the structure inside the lymph nodes leaves chemical signals that guide B cells through these complex tissues, like miniature lighthouses that guide safe navigation.
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PNAS: Research reveals the mechanism of systemic allergic reactions.
Time of Update: 2020-07-30
now, a team of researchers led by LMU immunopharmacologist Susanna Zierler and pharmacologist found that the activity of certain ion channel proteins in fat cells plays an important role in preventing abnormal and allergic reactions and ensuring that the immune response is not over-regulated.
