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JVI Highlight Sinalogy: Professor Zheng Chunfu of Fujian Medical University reveals the new mechanism of HSV-1 escape antiviral natural immunity.
Time of Update: 2020-07-22
on February 14, Professor Zheng Chunfu of Fujian Medical University published a research paper entitled: β - Catenin is required for CGAs / sting signaling pathway but agonized by HSV-1 US3 protein in the 5th issue of Journal of Virology.
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2019-nCoV Potential T-cells with B-cell antigen epitope.
Time of Update: 2020-07-22
they identified 405 viral peptides with good antigen presentation scores for human MHC-I and MHC-II alleles, and two potential neutralizing B-cell epitopes (440-460 and 494-506) near the binding domain of the 2019 ncov spike protein receptor.
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Cell Res . . . Chi Hongbo team publishes the latest signal networks in immune metabolism (worth collecting)
Time of Update: 2020-07-22
on March 20, 2020, Chi Hongbo team of St Jude Children's research hospital in Memphis, Tennessee, USA, published an online publication entitled "signaling networks in" on cell research This review summarizes the upstream regulatory proteins and signal transduction effectors of key serine / threonine kinase mediated signal transduction network, including PI3K – AGC kinase, mTOR and LKB1 – AMPK pathways, which regulate metabolism, especially in T cells.
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Nature sub-journal: Scientists have mapped the body's immune response to the new coronavirus for the first time.
Time of Update: 2020-07-22
in general, this study provides a new contribution to understanding the breadth and dynamics of the immune response in non severe covid-19 cases.
end reference: [1] doctors map body's coved-19 immune response: study [2] bread of consistent immune responses prior to patient recovery: a case report of non-severe coved-19
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Cancer Discovery . . . Dr. Chen Peiwen and others reveal the molecular mechanisms of double regulation of glioma stem cells and tumor immunity.
Time of Update: 2020-07-22
depinho (former president of MD Anderson Cancer Center) of University of Texas (Dr. Chen Peiwen as the first author of the article) published an article "circular Regulator Clock recurrences immune suppressive microglia into the GBM tumor" in cancer discovery We successfully identified the dual roles of clock related protein clock in regulating GSCs dryness and tumor immunity, and revealed its mechanism and potential value as a target for GBM therapy.
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"I'm so hard!" - Where do patients with rheumatoid arthritis and spinal arthritis in biological treatment severatins go in special periods?
Time of Update: 2020-07-22
The results of a real-world retrospective study showed that, regardless of the reason, the switch to adalimumab was effective in patients with spa who did not respond to the first TNF antagonist (such as infliximab or etanercept).
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What is the relationship between asthma and rheumatoid arthritis? The latest research tells you!
Time of Update: 2020-07-22
Recent studies have found that in a cohort of women with rheumatoid arthritis, a strong association has been observed between asthma and elevated anti citrullinated antibodies, and this association has nothing to do with smoking.
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Plant Cell. The regulatory mechanism of plant-based immunity- unambiguously mediated mRNA decay.
Time of Update: 2020-07-22
ineffective mutations of Upf1 (up-frameshift 1) or UPF3 increase plant disease resistance by increasing the level of salicylic acid (SA) and the expression of defense genes, and the autoimmunity of NMD damaged mutants is caused by the activation of TNL (TIR-NBS-LRR) type r-dependent immunity, but bacterial infection may inhibit the NMD mechanism in Arabidopsis thaliana [2,4].
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Nat E. The islet MHC-II peptide group reveals the main characteristics of autoimmune peptides.
Time of Update: 2020-07-22
although the autoimmune response caused by self-derived peptides has been widely discussed in autoimmune diabetes mellitus, the discovery and analysis of a series of strict biochemical tests are still needed to find out the true MHC-II epitopes in target organs and peripheral lymphoid tissues.
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Just do it! The pregnancy outcome of a pregnant woman with rheumatoid arthritis will be the same as that of the general population.
Time of Update: 2020-07-22
Studies have shown that ideal clinical treatment should be followed as far as possible, so that women with rheumatoid arthritis can have the best chance of pregnancy.
main results the hcqi stratified tool was used in 443 women with rheumatoid arthritis in their first pregnancy, including 141 women who followed the clinical pathway.
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Cellular and Molecular E. Suzhou University puts forward the role of extracellular vesicles in congenital immunomodulation.
Time of Update: 2020-07-22
recently, more and more evidences show that exosomes from tumor cells, host cells, even bacteria and parasites mediate the communication between the invader and innate immune cells, and play an irreplaceable role in the transmission of molecules from pathogens and donor cells.
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Too late for an immune response: How cytokine storms accelerate the disease.
Time of Update: 2020-07-22
if the pathogen is not removed in time, a variety of immune cells and cytokines will form a continuously amplified and hyperactive immune response, which will lead to uncontrolled inflammatory reaction and form cytokine storm, causing damage to organs and tissues.
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Professor Ping's team has issued two articles reporting on new advances in the study of PD-1H immunosuppressive pathways.
Time of Update: 2020-07-22
Professor Chen Liping's research team published an article in Science Translational Medicine on December 11, 2019, which reported the new function of pd-1h molecule: pd-1h (Vista) - mediated suppression of autoimmunity in systemic and cubaneous lupus erythematosus.
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Nat E. HIV-1 infection causes a steady state imbalance between congenital lymphocytes and natural killer cells.
Time of Update: 2020-07-22
The number of inflammatory related molecules MX1 and MPO positive cells in the gut were significantly increased in HIV-1 infected patients, indicating that ILC plays an important role in avoiding systemic inflammation caused by intestinal microorganisms.
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JEM . . . The bell wave group reveals the mechanism by which the ubiquity asse USP22 regulates the natural immune response of the antiviral.
Time of Update: 2020-07-22
However, the later studies showed that knockdown of kpna3 / 4 did not affect the expression of downstream genes such as interferon type I after virus infection, suggesting that there are other importin α family proteins involved in IRF3 nuclear translocation.
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What are the adverse effects in the long-term application of low-dose methotrexate? Is amino glucose so magical?
Time of Update: 2020-07-22
the Australian Society of Rheumatology issued the warning because the Australian drug regulatory agency (TGA) has reported hundreds of allergic reactions to glucosamine.
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Immunity . . . Dong Chen's team revealed that fever affects Th17 cell differentiation and autoimmune diseases.
Time of Update: 2020-07-22
on February 11, 2020, Dong Chen team, Institute of immunology, Tsinghua University, published a report entitled "textile temperature critically controls the differentiation and pathology of T helper 17" It was found that fever could enhance the differentiation of Th17 cells and the expression of IL-17 by promoting the sumoylation and nuclear entry of Smad4, enhance the inflammatory ability and aggravate the symptoms of autoimmune diseases related to Th17 cells in mice.
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The team of plant immunology at Northwest Agricultural and Forestry University revealed a new mechanism for wheat rust infection.
Time of Update: 2020-07-22
in this study, the secretory protein gene of Puccinia striiformis was used for the first time to create transgenic wheat materials resistant to stripe rust, and to reveal the mechanism of cell wall modifying enzymes of vegetative parasitic fungi to facilitate pathogen infection.
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Diagnosis and management of SLE during the outbreak: weighing the primary and handling carefully.
Time of Update: 2020-07-22
novel coronavirus pneumonia should be distinguished from SLE new cases or SLE disease activity or new crown pneumonia infection.
Novel coronavirus pneumonia, SLE professor believes that the treatment of patients with new crown pneumonia should be necessary if the disease is active and anti viral.
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Science cover story : New crown virus protrusion protein structure and ACE2 receptor structure.
Time of Update: 2020-07-22
Novel coronavirus pneumonia virus ( ) virus spike protein (gray) is associated with receptors on human cell surface (ACE2, deep pink), which makes new crown pneumonia virus able to infect human cells.
The novel coronavirus pneumonia / new crown virus research papers, editorials and news are free to the public.