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Asymptomatic hyperuric acidemia, cure or incurable?
Time of Update: 2020-07-22
The column "guide time" will focus on the diagnosis and treatment guidelines of Rheumatology and nephrology at home and abroad, and convey them to clinicians in a timely, comprehensive and accurate ma
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Diagnosis and management of SLE during the outbreak: weighing the primary and handling carefully.
Time of Update: 2020-07-22
novel coronavirus pneumonia should be distinguished from SLE new cases or SLE disease activity or new crown pneumonia infection.
Novel coronavirus pneumonia, SLE professor believes that the treatment of patients with new crown pneumonia should be necessary if the disease is active and anti viral.
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Immunity . . . Dong Chen's team revealed that fever affects Th17 cell differentiation and autoimmune diseases.
Time of Update: 2020-07-22
on February 11, 2020, Dong Chen team, Institute of immunology, Tsinghua University, published a report entitled "textile temperature critically controls the differentiation and pathology of T helper 17" It was found that fever could enhance the differentiation of Th17 cells and the expression of IL-17 by promoting the sumoylation and nuclear entry of Smad4, enhance the inflammatory ability and aggravate the symptoms of autoimmune diseases related to Th17 cells in mice.
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The 26-year-old male's spinal lesions were unable to walk and were diagnosed with "gout" after surgery.
Time of Update: 2020-07-22
Figure 1: thoracic MRI (middle thoracic epidural lesions with spinal cord compression) Figure 2: CT (thoracic facet joint lesions) on the second day of admission, the patient underwent t6-t9 laminectomy, resection of epidural mass and pedicle screw fixation (see figure 3).
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What are the adverse effects in the long-term application of low-dose methotrexate? Is amino glucose so magical?
Time of Update: 2020-07-22
the Australian Society of Rheumatology issued the warning because the Australian drug regulatory agency (TGA) has reported hundreds of allergic reactions to glucosamine.
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Nat E. HIV-1 infection causes a steady state imbalance between congenital lymphocytes and natural killer cells.
Time of Update: 2020-07-22
The number of inflammatory related molecules MX1 and MPO positive cells in the gut were significantly increased in HIV-1 infected patients, indicating that ILC plays an important role in avoiding systemic inflammation caused by intestinal microorganisms.
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Nature sub-journal: Scientists have mapped the body's immune response to the new coronavirus for the first time.
Time of Update: 2020-07-22
in general, this study provides a new contribution to understanding the breadth and dynamics of the immune response in non severe covid-19 cases.
end reference: [1] doctors map body's coved-19 immune response: study [2] bread of consistent immune responses prior to patient recovery: a case report of non-severe coved-19
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Professor Ping's team has issued two articles reporting on new advances in the study of PD-1H immunosuppressive pathways.
Time of Update: 2020-07-22
Professor Chen Liping's research team published an article in Science Translational Medicine on December 11, 2019, which reported the new function of pd-1h molecule: pd-1h (Vista) - mediated suppression of autoimmunity in systemic and cubaneous lupus erythematosus.
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A 59-year-old woman who was diagnosed with rheumatoid arthritis now has a rash and fingertip ulcer. Wind list is finalized.
Time of Update: 2020-07-22
A 59 year old woman once diagnosed with rheumatoid arthritis (RA), during which she received intermittent treatment, followed by rashes, ulcers and even gangrene.
when the patient first diagnosed RA, physical examination showed that the patient had multiple subcutaneous nodules, involving the upper limbs, including the elbow, forearm and multiple metacarpophalangeal joints (see Figure 1).
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Cancer Discovery . . . Dr. Chen Peiwen and others reveal the molecular mechanisms of double regulation of glioma stem cells and tumor immunity.
Time of Update: 2020-07-22
depinho (former president of MD Anderson Cancer Center) of University of Texas (Dr. Chen Peiwen as the first author of the article) published an article "circular Regulator Clock recurrences immune suppressive microglia into the GBM tumor" in cancer discovery We successfully identified the dual roles of clock related protein clock in regulating GSCs dryness and tumor immunity, and revealed its mechanism and potential value as a target for GBM therapy.
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Cellular and Molecular E. Suzhou University puts forward the role of extracellular vesicles in congenital immunomodulation.
Time of Update: 2020-07-22
recently, more and more evidences show that exosomes from tumor cells, host cells, even bacteria and parasites mediate the communication between the invader and innate immune cells, and play an irreplaceable role in the transmission of molecules from pathogens and donor cells.
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JEM . . . The bell wave group reveals the mechanism by which the ubiquity asse USP22 regulates the natural immune response of the antiviral.
Time of Update: 2020-07-22
However, the later studies showed that knockdown of kpna3 / 4 did not affect the expression of downstream genes such as interferon type I after virus infection, suggesting that there are other importin α family proteins involved in IRF3 nuclear translocation.
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Too late for an immune response: How cytokine storms accelerate the disease.
Time of Update: 2020-07-22
if the pathogen is not removed in time, a variety of immune cells and cytokines will form a continuously amplified and hyperactive immune response, which will lead to uncontrolled inflammatory reaction and form cytokine storm, causing damage to organs and tissues.
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New molecular mechanisms regulate macrophages in the immune system.
Time of Update: 2020-07-22
"one of the main functions of macrophages in these cavities is to maintain homeostasis by removing dead cells," Dr. Richter explained.
"our study may have implications for the treatment of disease progression (such as cancer) caused by serous macrophages, or the repair of damaged tissues (such as myocardial infarction).
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Incubate immune cells with adult stem cells and treat autoimmune diseases.
Time of Update: 2020-07-22
recently, creative medical technology holdings announced that it has found a new characteristic of regenerative cells, and uses this new feature to change immune cells and develop a personalized therapy for autoimmune diseases, immcelz ™。 the company also said that immcelz Gamma It may be the first adoptive immunotherapy for autoimmune diseases.
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The development of T-cell response spectrum helps to understand immune diseases.
Time of Update: 2020-07-22
researchers at Wellcome Sanger Institute, GSK, Biogen and open targets have found that T cells respond to immune signals very differently after exposure to more "training", rather than simply transiting from naive to experienced.
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Just do it! The pregnancy outcome of a pregnant woman with rheumatoid arthritis will be the same as that of the general population.
Time of Update: 2020-07-22
Studies have shown that ideal clinical treatment should be followed as far as possible, so that women with rheumatoid arthritis can have the best chance of pregnancy.
main results the hcqi stratified tool was used in 443 women with rheumatoid arthritis in their first pregnancy, including 141 women who followed the clinical pathway.
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"I'm so hard!" - Where do patients with rheumatoid arthritis and spinal arthritis in biological treatment severatins go in special periods?
Time of Update: 2020-07-22
The results of a real-world retrospective study showed that, regardless of the reason, the switch to adalimumab was effective in patients with spa who did not respond to the first TNF antagonist (such as infliximab or etanercept).
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Cell Res . . . Chi Hongbo team publishes the latest signal networks in immune metabolism (worth collecting)
Time of Update: 2020-07-22
on March 20, 2020, Chi Hongbo team of St Jude Children's research hospital in Memphis, Tennessee, USA, published an online publication entitled "signaling networks in" on cell research This review summarizes the upstream regulatory proteins and signal transduction effectors of key serine / threonine kinase mediated signal transduction network, including PI3K – AGC kinase, mTOR and LKB1 – AMPK pathways, which regulate metabolism, especially in T cells.
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What is the relationship between asthma and rheumatoid arthritis? The latest research tells you!
Time of Update: 2020-07-22
Recent studies have found that in a cohort of women with rheumatoid arthritis, a strong association has been observed between asthma and elevated anti citrullinated antibodies, and this association has nothing to do with smoking.
