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Nature. In a major new discovery, Tsinghua University's Bohai team has revealed a mechanism by which men's immunity is lower than women's.
Time of Update: 2020-07-23
The study identified gpr174 as the receptor of CCL21, and revealed that its chemotaxis on activated B cells was the mechanism of humoral response and autoimmune dimorphism.
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Nature's EIElogy . . . Cao Xuetao's team made new advances in congenital immunity, revealing new cellular pathways.
Time of Update: 2020-07-23
The research found that microRNA miR-1 can degrade long non coding RNA in cytoplasm Sros1 indirectly stabilizes STAT1 mRNA to promote IFN - γ - mediated Listeria clearance in macrophages.
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EMBO Mol Med. Huang shengcong and others found the "King of Cancer" treatment of new ideas.
Time of Update: 2020-07-23
in order to simulate this mutant tumor, the researchers used CRISPR technology to establish a pancreatic cancer model with tgfbr2 function loss mutation, and found that anti TGF β therapy can inhibit the tumor matrix promoting signal in this type of tumor, without side effects of stimulating tumor cell growth, and ultimately significantly prolong the survival time of animals.
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Immunity: Luben team decrypts bacterial infection-induced clotting response mechanism, CellPress dialogue scientist.
Time of Update: 2020-07-23
in December 2019, Professor Lu Ben from Xiangya Third Hospital of Central South University elaborated caspase-11 and its enzyme digestion substrate gasdermin-11 in the journal immunity of cell press cell publishing house D (gsdmd) plays a key role in the process of DIC induced by bacterial infection, which reveals the molecular mechanism of DIC induced by gram-negative bacteria, and provides a new idea for the prevention and treatment of septic DIC in the future.
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Science: "Listening to" bacterial dialogue, another evolutionary strategy of an "arms race" between somatic cells and bacteria.
Time of Update: 2020-07-23
By analyzing the infection process of Pseudomonas aeruginosa in zebrafish, mice and human cells, the researchers found that host cells could detect the communication between bacteria through aromatic receptor (AHR).
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Measles virus causes immune system to "amnesia"? Tightening the vaccine to prevent "seat belts"
Time of Update: 2020-07-23
The study found that, like the antibody, due to measles infection, the previous antigen-specific B cell receptor sequence was also sharply reduced.
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Treatment of aggressive spina bifida, do you use anti-steroidal anti-inflammatory drugs?
Time of Update: 2020-07-23
★ basic medication principles: ① the elderly often choose drugs with short half-life, and the dosage should be smaller to ensure safety; ② patients with severe disease activity and pain usually choose acemetacin and indomethacin, etc.; ③ if patients are accompanied with 2-3 gastrointestinal risk factors, they should add drugs to prevent gastric ulcer or use selective cyclooxygenase-2 (COX-2) If there is a renal risk factor, NSAIDs should be selected carefully.
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Two MP articles reveal the molecular mechanisms of plant suppression of autoimmune!
Time of Update: 2020-07-23
in conclusion, the results suggest that camta inhibits the biosynthesis of SA and NHP by regulating the expression of sard1 and cbp60g, and the SA and NHP pathways cooperate with each other to optimize the immune response of plants.
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PNAS: Cytotoxic CD4 T cells are the key to longevity.
Time of Update: 2020-07-23
Using single cell RNA analysis, scientists from RIKEN Integrated Medical Science Center (IMS) and Keio University Medical School found that super centenarians (over 110 years old) have an immune cell called cytotoxic CD4 T cells.
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With 20 years of recognition, Science today reveals a new mechanism for immune T-cells to identify risks.
Time of Update: 2020-07-23
it is believed that T cell receptors are able to recognize specific signals from pathogens by binding to MHC or MHC like molecules in a "head-to-head" manner.
specifically, the researchers obtained a three-dimensional structure in which the gamma delta T cell receptor binds to a molecule similar to MHC.
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Immunity . . . The Whine group clarified the conjugate relationship between tumor immunotherapy targets.
Time of Update: 2020-07-23
on November 19, 2019, the team of Enfu Hui of the University of California, San Diego (UCSD) published a long article "PD-L1: CD80 CIS heterodimer triggers the co stitution receptor CD28 while expressing the inhibitor PD-1 and CTLA-4 Pathways "reveals an unexpected conjugation between PD-1 and CTLA-4 pathways, and explains why blocking PD-L1 and CTLA-4 at the same time can more effectively activate the anti-tumor immunity of T cells.
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The 26-year-old male's spinal lesions were unable to walk and were diagnosed with "gout" after surgery.
Time of Update: 2020-07-22
Figure 1: thoracic MRI (middle thoracic epidural lesions with spinal cord compression) Figure 2: CT (thoracic facet joint lesions) on the second day of admission, the patient underwent t6-t9 laminectomy, resection of epidural mass and pedicle screw fixation (see figure 3).
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A 59-year-old woman who was diagnosed with rheumatoid arthritis now has a rash and fingertip ulcer. Wind list is finalized.
Time of Update: 2020-07-22
A 59 year old woman once diagnosed with rheumatoid arthritis (RA), during which she received intermittent treatment, followed by rashes, ulcers and even gangrene.
when the patient first diagnosed RA, physical examination showed that the patient had multiple subcutaneous nodules, involving the upper limbs, including the elbow, forearm and multiple metacarpophalangeal joints (see Figure 1).
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Rheumatoid arthritis for many years, but because of a "cold" into the emergency? ! . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Time of Update: 2020-07-22
Massive pericardial effusion 。 the elderly female patient has a history of rheumatoid arthritis for many years, and the treatment is irregular.
for our patient, the manifestation was extremely rare large amount of pleural and pericardial effusion.
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Hortic Res . . . The team of Chen Faxuan of Nanjing Agricultural University revealed the timing immune response of chrysanthemums to the invasion of black spot bacteria.
Time of Update: 2020-07-22
Fig. 1 Evaluation of resistance to black spot of Chrysanthemum 'Shenma' and 'zaoyihong' was published online in March 2020 by horticulture research, a temporary gene expression map of chrysanthemum leaves affected with Alternaria alternata Reeves different stages of Defense mechanisms.
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Asymptomatic hyperuric acidemia, cure or incurable?
Time of Update: 2020-07-22
The column "guide time" will focus on the diagnosis and treatment guidelines of Rheumatology and nephrology at home and abroad, and convey them to clinicians in a timely, comprehensive and accurate ma
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The development of T-cell response spectrum helps to understand immune diseases.
Time of Update: 2020-07-22
researchers at Wellcome Sanger Institute, GSK, Biogen and open targets have found that T cells respond to immune signals very differently after exposure to more "training", rather than simply transiting from naive to experienced.
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New molecular mechanisms regulate macrophages in the immune system.
Time of Update: 2020-07-22
"one of the main functions of macrophages in these cavities is to maintain homeostasis by removing dead cells," Dr. Richter explained.
"our study may have implications for the treatment of disease progression (such as cancer) caused by serous macrophages, or the repair of damaged tissues (such as myocardial infarction).
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B-cells can predict the response of immunotherapy.
Time of Update: 2020-07-22
Three papers published this week in nature suggest that B cells in larger immune clusters can be used to predict the positive response of some cancer patients to immunotherapy.
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JVI Highlight Sinalogy: Professor Zheng Chunfu of Fujian Medical University reveals the new mechanism of HSV-1 escape antiviral natural immunity.
Time of Update: 2020-07-22
on February 14, Professor Zheng Chunfu of Fujian Medical University published a research paper entitled: β - Catenin is required for CGAs / sting signaling pathway but agonized by HSV-1 US3 protein in the 5th issue of Journal of Virology.