JVI Highlight Sinalogy: Professor Zheng Chunfu of Fujian Medical University reveals the new mechanism of HSV-1 escape antiviral natural immunity.

Herpes simplex virus (HSV) is a typical representative of herpesvirus. It is named after herpes simplex due to blister dermatitis in acute stage of infection.can cause a variety of human diseases, such as gingivitis, keratoconjunctivitis, encephalitis, reproductive system infection and neonatal infection. According to the difference of antigenicity, HSV can be divided into two serotypes: HSV-1 and HSV-2.the DNA of the two types of viruses has 50% homology, and has the common antigen and the specific antigen.human is the natural host of herpes simplex virus, and the infection is very common in the population. The most susceptible period of primary herpes simplex virus infection is infants aged from 6 months to 3 years, and about 70% to 90% of adults have antibodies to HSV-1.on February 14, Professor Zheng Chunfu of Fujian Medical University published a research paper entitled: β - Catenin is required for CGAs / sting signaling pathway but agonized by HSV-1 US3 protein in the 5th issue of Journal of Virology.this study found that HSV-1 encoded US3 protein blocked type I IFN induced by CGAs sting signaling pathway through hyperphosphorylation catenin, thus escaping the host's antiviral innate immunity.this paper was selected as spotlight by jvi magazine. Spotlight is an important breakthrough article recommended by jvi editorial department, and only 5 articles are included in each issue.it is worth mentioning that there are 11 articles related to herpes virus in this issue, including 5 articles related to HSV-1, and this paper is the only one that has been highlighted.in recent years, Professor Zheng Chunfu's team has been committed to the research on the molecular mechanism of antiviral innate immunity and the interaction between virus and host. It has systematically revealed that HSV-1 virus protein can escape the host's anti-virus immunity through multiple adaptor proteins acting on the antiviral innate immune signal pathway. The research results have been published in the journals such as mbio and jvi, among which the corresponding author on jvi has published 21 High level research papers.the team of Professor Zheng Chunfu introduced Zheng Chunfu, male, distinguished professor and doctoral supervisor of Fujian Medical University.candidates of the "Hundred Talents Program" of Chinese Academy of Sciences (Wuhan Virus Research Institute, 2007-2012), and candidates of Jiangsu Province "mass entrepreneurship and innovation talents" program (Suzhou University, 2013-2017).mainly engaged in the research on the molecular mechanism of the interaction between herpes simplex virus type I (HSV-1) infection and host, and made outstanding achievements in the research of HSV-1 escaping the host's antiviral innate immunity, including blood, mbio, Journal of Virology (21 articles), Journal of Virology (21 articles) Immunology and other journals published more than 70 SCI papers, with a total citation of nearly 2000 times. The h-index was 22. He was invited to write gems review for Journal of Virology, an international authoritative journal of Virology. Among them, two Journal of Virology papers were selected as highlights by the editorial department.it is worth mentioning that Professor Zheng Chunfu won the top 25 reviewers of Journal of Virology in 2019 and the top 1% peer review award in the field of Microbiology in publons in 2019.he is now the editorial board member of Journal of Virology and frontiers in immunology, deputy editor in chief of frontier in microbiology, deputy editor in chief of Virology Journal, and member of Virology Committee of Chinese society of microbiology.it has successively undertaken 2 sub projects of "973" and 6 general projects of National Natural Science.has been granted one invention patent in China.identify the QR code and understand the latest developments in the laboratory