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Cell . . . Important advances in neuroimmune - Skin TRPV1 neurons activate type 17 to prevent the immune system.
Time of Update: 2020-07-23
Some of these tentacles sense temperature and some feel pressure, while neurons expressing TRPV1 specifically sense physical pain and transmit the pain sensation to the spine and brain [1]; the other is immune cells When there are external bacteria and viruses invading or their own diseases occur, they quickly gather and release cytokines to resist foreign enemies.
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PNAS . . . The rebirth of a corn mutant--analyzes the dual regulation mechanism of corn G protein for development and immunity.
Time of Update: 2020-07-23
Maize is not only an important crop in China and the world, but also a model plant for genetics and developmental biology. the improvement of comprehensive yield of maize depends on the optimization o
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Scientists have discovered a protective shield for the human body.
Time of Update: 2020-07-23
when a tissue is damaged (whether by accident or by surgery), the body will quickly gather immune cells to the injured site, and then phagocytize and kill the invading pathogens by releasing toxic factors (such as unstable molecules containing reactive oxygen species, such as peroxides), so as to fight against infection.
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Tang Dingzhong team and Zhou Jianmin team published a review of "Plant Immune Signals: Two Frontier Research Advances"
Time of Update: 2020-07-23
this review summarizes the latest achievements in the field of plant immunity, especially discusses the activation mechanism of PRRS on the surface of plant cell membrane and NLRs protein, dynamic regulation and molecular mechanism of activating downstream immune signals.
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The study revealed a new mechanism for cholesterol metabolites to regulate innate immune resistance.
Time of Update: 2020-07-23
In viral or bacterial infection, host cells can participate in anti infection through a variety of effective ways. among them, viral infection can induce host cells to change the expression of cholest
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Two Mol Plants reveal new mechanisms by which CAMTA transcription factors participate in regulating plant immune response.
Time of Update: 2020-07-23
recently, molecular plant published online a paper entitled Arabidopsis camta transcription factors regularize piperic acid biosynthesis and priming of immunity genes by Michael thomashow research group of Michigan State University in the United States and Xin Li research group of University of British Columbia in Canada entitled redundant Camta transcription factors negatively regulate the biosynthesis of salicylic acid and n-hydroxypeptic acid by modulating the expression of sard1 and cbp60g.
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Tang Dingzhong/Zhou Jianmin published a review article on "Plant Immune Signals: Two Frontier Research Progresses".
Time of Update: 2020-07-23
this review summarizes the latest achievements in the field of plant immunity, especially discusses the activation mechanism of PRRS on the surface of plant cell membrane and NLRs protein, dynamic regulation and molecular mechanism of activating downstream immune signals.
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Tang Dingzhong/Zhou Jianmin co-published the "Plant Immune Signals: Two Frontier Research Progress" review article.
Time of Update: 2020-07-23
this review summarizes the latest achievements in the field of plant immunity, especially discusses the activation mechanism of PRRS on the surface of plant cell membrane and NLRs protein, dynamic regulation and molecular mechanism of activating downstream immune signals.
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Professor Ping's team, Science, published a paper that solved the mystery of lupus with new ideas for fighting cancer.
Time of Update: 2020-07-23
If you know a patient named qingwufeiyang, you are exposed to age (photo source: 123rf) in this study, scientists found that when mice were lack of immunosuppressive factor pd-1h, more than one-third of young female mice developed skin damage symptoms such as hair loss and lupus erythematosus, and half of them developed heart and other organ problems.
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Science Sub-journal: "Twin Killer" - TGF-beta - walking at both ends of cancer's "positive evil"
Time of Update: 2020-07-23
the results showed that TGF - β secreted by tumor can not only damage the metabolism and mitochondrial activity of CD4 T cells, but also produce a key anti-tumor molecule, IFN - γ, which is related to the phosphorylation of Smad Protein (which plays a key role in the process of transferring TGF - β signal from cell surface receptor to nucleus), but not to nuclear translocation.
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Structural damage to mid-axis spinal arthritis, which can cause these hazards to patients!
Time of Update: 2020-07-23
results univariate analysis showed that body mass index (BMI), smoking time, symptom duration, delayed diagnosis, hip involvement and sacroiliac arthritis classification were significantly associated with the modified stoke ankylosing spondylitis spine score (msasss) (Table 1).
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Often mouth ulcers, with these symptoms? Beware of white-stuffed disease!
Time of Update: 2020-07-23
According to Professor Yang Xiuyan, the most common symptoms of Behcet's disease are oral ulcer and vulvar ulcer.
According to Professor Yang Xiuyan, Behcet's disease may also be manifested on the skin, such as severe acne, nodular erythema, difficult wound healing and acupuncture reaction.
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Nat E. Zhou Rongbin/Jiang Wei/Zhu Shu cooperation reveals the role and mechanism of intestinal symbiotic virus in maintaining the immune stability of the intestinal mucosa.
Time of Update: 2020-07-23
these results suggest that enterosymbiotic viruses are important for maintaining the homeostasis of IELs. subsequently, in order to explore how the enterosymbiotic virus is perceived and regulated by the body, researchers used a variety of innate immune recognition receptors and their downstream signal protein deficient mice to analyze the proportion and number of intestinal IELs cell subsets.
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Nature. In a major new discovery, Tsinghua University's Bohai team has revealed a mechanism by which men's immunity is lower than women's.
Time of Update: 2020-07-23
The study identified gpr174 as the receptor of CCL21, and revealed that its chemotaxis on activated B cells was the mechanism of humoral response and autoimmune dimorphism.
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Science: "Listening to" bacterial dialogue, another evolutionary strategy of an "arms race" between somatic cells and bacteria.
Time of Update: 2020-07-23
By analyzing the infection process of Pseudomonas aeruginosa in zebrafish, mice and human cells, the researchers found that host cells could detect the communication between bacteria through aromatic receptor (AHR).
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Immunity: Luben team decrypts bacterial infection-induced clotting response mechanism, CellPress dialogue scientist.
Time of Update: 2020-07-23
in December 2019, Professor Lu Ben from Xiangya Third Hospital of Central South University elaborated caspase-11 and its enzyme digestion substrate gasdermin-11 in the journal immunity of cell press cell publishing house D (gsdmd) plays a key role in the process of DIC induced by bacterial infection, which reveals the molecular mechanism of DIC induced by gram-negative bacteria, and provides a new idea for the prevention and treatment of septic DIC in the future.
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Expert Perspectives . . . Shouldpatients with autoimmune diseases not receive immunotherapy?
Time of Update: 2020-07-23
However, due to immune related adverse events (Irae), patients with previous autoimmune diseases are often excluded from the clinical trials of immunotherapy Whether patients can benefit from immunotherapy is doubtful.
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Professor Zhang Xiao: For patients with hard skin, it is recommended to do high-resolution CT in the lungs once a year.
Time of Update: 2020-07-23
Based on the data from the senscis study, the U.S. drug administration (FDA) approved the extension of indications for idiopathic pulmonary fibrosis (IPF) to SSC ILD, and became the first and only drug to slow down the decline of lung function in patients with SSc ILD.
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Treatment of aggressive spina bifida, do you use anti-steroidal anti-inflammatory drugs?
Time of Update: 2020-07-23
★ basic medication principles: ① the elderly often choose drugs with short half-life, and the dosage should be smaller to ensure safety; ② patients with severe disease activity and pain usually choose acemetacin and indomethacin, etc.; ③ if patients are accompanied with 2-3 gastrointestinal risk factors, they should add drugs to prevent gastric ulcer or use selective cyclooxygenase-2 (COX-2) If there is a renal risk factor, NSAIDs should be selected carefully.
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PNAS: Cytotoxic CD4 T cells are the key to longevity.
Time of Update: 2020-07-23
Using single cell RNA analysis, scientists from RIKEN Integrated Medical Science Center (IMS) and Keio University Medical School found that super centenarians (over 110 years old) have an immune cell called cytotoxic CD4 T cells.
