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Why are the "antibody factories" in men and women not the same? The Bohai team today published a paper in Nature revealing important mechanisms.
Time of Update: 2020-07-23
today, a research team led by Professor Qi Hai of Tsinghua University published a paper online in nature, a top academic journal, to help us understand why there are differences in humoral immune response between men and women, and to reveal the cellular mechanism behind this phenomenon.
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PNAS . . . The rebirth of a corn mutant--analyzes the dual regulation mechanism of corn G protein for development and immunity.
Time of Update: 2020-07-23
Maize is not only an important crop in China and the world, but also a model plant for genetics and developmental biology. the improvement of comprehensive yield of maize depends on the optimization o
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Cell . . . Important advances in neuroimmune - Skin TRPV1 neurons activate type 17 to prevent the immune system.
Time of Update: 2020-07-23
Some of these tentacles sense temperature and some feel pressure, while neurons expressing TRPV1 specifically sense physical pain and transmit the pain sensation to the spine and brain [1]; the other is immune cells When there are external bacteria and viruses invading or their own diseases occur, they quickly gather and release cytokines to resist foreign enemies.
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Professor Ping's team, Science, published a paper that solved the mystery of lupus with new ideas for fighting cancer.
Time of Update: 2020-07-23
If you know a patient named qingwufeiyang, you are exposed to age (photo source: 123rf) in this study, scientists found that when mice were lack of immunosuppressive factor pd-1h, more than one-third of young female mice developed skin damage symptoms such as hair loss and lupus erythematosus, and half of them developed heart and other organ problems.
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Express . . . For the treatment of rheumatoid arthritis, Gilead used priority review vouchers to submit a new jak1 inhibitor application.
Time of Update: 2020-07-23
▎ yaomingkant / report today, Gilead Sciences announced that it has submitted a new drug application (NDA) for Jak1 inhibitor filgtinib to the U.S. FDA for the treatment of adult patients with moderate to severe rheumatoid arthritis.
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Wang Hongyan/Wei Bin collaboration reveals a new mechanism for cholesterol metabolism regulation of innate immune resistance to infection, cellPress dialogue scientists.
Time of Update: 2020-07-23
Viral infection can induce host cells to change the expression of cholesterol metabolizing enzymes and metabolites, and cholesterol metabolism can also regulate the antiviral response of host cells.
recent international frontier work indicates that targeting individual key cholesterol metabolic enzymes and metabolites can improve the function of antiviral infection [1] [2] [3].
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Tang Dingzhong/Zhou Jianmin co-published the "Plant Immune Signals: Two Frontier Research Progress" review article.
Time of Update: 2020-07-23
this review summarizes the latest achievements in the field of plant immunity, especially discusses the activation mechanism of PRRS on the surface of plant cell membrane and NLRs protein, dynamic regulation and molecular mechanism of activating downstream immune signals.
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The Tian Zhendong team and collaborators at Huazhong Agricultural University revealed the mechanisms by which two E3 ubiquitin-linked enzyme cascades regulate the plant immune response.
Time of Update: 2020-07-23
many E3 ubiquitin ligases regulate plant immune response positively or negatively by promoting the degradation of their substrates.
the above research system reveals how the two E3 ubiquitin ligases can finely regulate plant immune response through cascading degradation of their respective targets.
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Tang Dingzhong team and Zhou Jianmin team published a review of "Plant Immune Signals: Two Frontier Research Advances"
Time of Update: 2020-07-23
this review summarizes the latest achievements in the field of plant immunity, especially discusses the activation mechanism of PRRS on the surface of plant cell membrane and NLRs protein, dynamic regulation and molecular mechanism of activating downstream immune signals.
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Often mouth ulcers, with these symptoms? Beware of white-stuffed disease!
Time of Update: 2020-07-23
According to Professor Yang Xiuyan, the most common symptoms of Behcet's disease are oral ulcer and vulvar ulcer.
According to Professor Yang Xiuyan, Behcet's disease may also be manifested on the skin, such as severe acne, nodular erythema, difficult wound healing and acupuncture reaction.
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Tang Dingzhong/Zhou Jianmin published a review article on "Plant Immune Signals: Two Frontier Research Progresses".
Time of Update: 2020-07-23
this review summarizes the latest achievements in the field of plant immunity, especially discusses the activation mechanism of PRRS on the surface of plant cell membrane and NLRs protein, dynamic regulation and molecular mechanism of activating downstream immune signals.
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Two Mol Plants reveal new mechanisms by which CAMTA transcription factors participate in regulating plant immune response.
Time of Update: 2020-07-23
recently, molecular plant published online a paper entitled Arabidopsis camta transcription factors regularize piperic acid biosynthesis and priming of immunity genes by Michael thomashow research group of Michigan State University in the United States and Xin Li research group of University of British Columbia in Canada entitled redundant Camta transcription factors negatively regulate the biosynthesis of salicylic acid and n-hydroxypeptic acid by modulating the expression of sard1 and cbp60g.
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Two MP articles reveal the molecular mechanisms of plant suppression of autoimmune!
Time of Update: 2020-07-23
in conclusion, the results suggest that camta inhibits the biosynthesis of SA and NHP by regulating the expression of sard1 and cbp60g, and the SA and NHP pathways cooperate with each other to optimize the immune response of plants.
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Immunity . . . The Whine group clarified the conjugate relationship between tumor immunotherapy targets.
Time of Update: 2020-07-23
on November 19, 2019, the team of Enfu Hui of the University of California, San Diego (UCSD) published a long article "PD-L1: CD80 CIS heterodimer triggers the co stitution receptor CD28 while expressing the inhibitor PD-1 and CTLA-4 Pathways "reveals an unexpected conjugation between PD-1 and CTLA-4 pathways, and explains why blocking PD-L1 and CTLA-4 at the same time can more effectively activate the anti-tumor immunity of T cells.
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PNAS: Cytotoxic CD4 T cells are the key to longevity.
Time of Update: 2020-07-23
Using single cell RNA analysis, scientists from RIKEN Integrated Medical Science Center (IMS) and Keio University Medical School found that super centenarians (over 110 years old) have an immune cell called cytotoxic CD4 T cells.
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Yale scientists have developed a new cancer immunotherapy.
Time of Update: 2020-07-23
Chen said: "this is a new immunotherapy, which can induce anti-tumor immunity through multiple activation of tumor endogenous genes.
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Expert Perspectives . . . Shouldpatients with autoimmune diseases not receive immunotherapy?
Time of Update: 2020-07-23
However, due to immune related adverse events (Irae), patients with previous autoimmune diseases are often excluded from the clinical trials of immunotherapy Whether patients can benefit from immunotherapy is doubtful.
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JIPB Tang Dingzhong/Zhou Jianmin co-published the "Plant Immune Signals: Two Frontier Research Progress" review article.
Time of Update: 2020-07-23
this review summarizes the latest achievements in the field of plant immunity, especially discusses the activation mechanism of PRRS on the surface of plant cell membrane and NLRs protein, dynamic regulation and molecular mechanism of activating downstream immune signals.
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Science: Why do some skin care products and cosmetics cause skin allergies?
Time of Update: 2020-07-23
a recent study in science immunology showed that some components in skin products combine with CD1a on the skin surface to replace the natural fat in skin cells, thus activating immune T cells and causing allergy.
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Professor Zhang Xiao: For patients with hard skin, it is recommended to do high-resolution CT in the lungs once a year.
Time of Update: 2020-07-23
Based on the data from the senscis study, the U.S. drug administration (FDA) approved the extension of indications for idiopathic pulmonary fibrosis (IPF) to SSC ILD, and became the first and only drug to slow down the decline of lung function in patients with SSc ILD.