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Nature: The Tsinghua Bohai Task Force found a new mechanism for the difference between the sexes in the antibody immune response.
Time of Update: 2020-07-23
On December 26, Professor Qi Hai, from the Institute of immunology, Tsinghua University, published a report entitled "a gpr174-ccl21 module imparts sexual dimorphism to human" in nature In this paper, we found a new mechanism leading to the difference of antibody immune response between men and women, which provided new ideas and potential new targets for enhancing the effect of vaccination and the treatment of antibody mediated autoimmune diseases.
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Immunity is of particular interest. Potential disadvantages and solutions for the Cre-Loxp system.
Time of Update: 2020-07-23
for the immune system, CRE loxP system is widely used in various scientific problems, to solve cell type specific knockout, mutation, rearrangement and other issues, as well as to conduct lineage tracking research.
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Express . . . Treatment of lupus nephritis, GSK lupus treatment reached the end of phase 3.
Time of Update: 2020-07-23
▎ pharmaceutic Kant / report today, GSK announced that its intravenous infusion therapy of benlysta (belimumab) has achieved the primary and all secondary endpoints of the phase 3 trial bliss-ln for patients with lupus nephritis (LN).
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It revealed that glutamine blocking overcomes tumor immune evasion mechanism.
Time of Update: 2020-07-23
chemical structures of Don and jhu-083, a glutamine antagonist, are shown in translational oncology, 2019, doi:10.1016/j.tranon.2019.05.013 。 to this end, Jonathan Powell, deputy director of the Institute of cancer immunotherapy, Kimmel Cancer Center, Johns Hopkins University, and his team prepared its precursor drug jhu-083 by adding chemical groups to Don and blocking its carboxyl and amino groups.
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Chen Zhijian, Winner of the Science Breakthrough Award: Grasping the "Brake" and "Throttle" of the Immune System
Time of Update: 2020-07-23
Chen Zhijian also pointed out that the combination of cgamp and PD-L1 inhibitors can play a better anti-cancer effect by stepping on the "accelerator" and releasing the "brake".
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New Knowledge Of human immune guards "combat effectiveness" upgrade "secret"
Time of Update: 2020-07-23
Virus infecting human body is just like an alien invading our home earth. To deal with these "extremely destructive" invaders, how to strengthen "defense" and "army construction" to protect human home
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Biologics can be "addictive" after a long time? That rheumatic patient can't fight, how to fight?
Time of Update: 2020-07-23
in fact, most of the patients who use biological agents can reduce or even stop using biological agents after their condition is stable.
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Ash is the world's first BCMA-CD19 composite CAR for autoantibodies-mediated diseases.
Time of Update: 2020-07-23
a recent study in the authoritative journal Nature showed that in mouse model, using CD19 car-t to remove B cells in the treatment of SLE, the effect of significantly reducing antibody was observed, and the clinical symptoms were reversed.
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Science sub-journal: Finally know why some skin care products and cosmetics are prone to skin allergies.
Time of Update: 2020-07-23
} allergens in skin care products and cosmetics are common causes of contact dermatitis (photo source: 123rf).
This natural product is a common contact allergen and can cause severe rashes in allergic individuals (photo source: public) CD1a is a kind of antigen presenting molecule.
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Our powerful intestinal immune function may have been formed from the age of 14...
Time of Update: 2020-07-23
Image Source: konnikova, a developmental cell, said: "we were surprised to find that in the gut, almost complete immune function was formed as early as 14 weeks and remained stable throughout infancy.
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Immunity . . . With new developments, The Dong Chen team at Tsinghua University revealed that transcription factor Tox2 can promote the development of T-cells by regulating chromatin accessibility.
Time of Update: 2020-07-23
integrated whole genome BCL6 occupation and differential gene expression analysis in TFH cells suggested that transcription factor tox2 played an important role in the differentiation of TFH cells.
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The plant immunization team at Northwest Agricultural and Forestry University reported that pathogenic fungi regulate the pathogenic mechanism of host immunity by attacking chlorophyre.
Time of Update: 2020-07-23
recently, the plant immunity research team of northwest agricultural and Forestry University published an online report entitled "an effector protein of the wheat strip rust fungus targets chloroplast and suppresses chloroplast function" in the journal Nature communications It is the first time to report the pathogenic mechanism that pathogenic fungi regulate plant immunity by attacking chloroplast, and reveal a new way of infection and pathogenicity by living vegetative parasitic fungi.
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The Sophien Kamoun research team at Imperial College London identified the MADA base sequence, a conservative NLR body function component in the plant.
Time of Update: 2020-07-23
recently, Sophien kamoun research group of Imperial College London, UK, published a report entitled "an N-terminal motion in NLR immune receptors is functionally observed across distantly related plant" In this study, a cc-nlr helper protein nrc4 was identified by using a random truncated library constructed by Mu transposition system in vitro.
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Nature Sub-Journal: Cao Xuetao's team has reissued a top-level paper, making new advances in congenital immunity, revealing a new type of non-coding RNA regulatory network.
Time of Update: 2020-07-23
this study found that miR-1 promoted IFN - γ - mediated Listeria clearance in macrophages by degrading lncrna sros1 and indirectly stabilizing STAT1 mRNA.
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Why are the "antibody factories" in men and women not the same? The Bohai team today published a paper in Nature revealing important mechanisms.
Time of Update: 2020-07-23
today, a research team led by Professor Qi Hai of Tsinghua University published a paper online in nature, a top academic journal, to help us understand why there are differences in humoral immune response between men and women, and to reveal the cellular mechanism behind this phenomenon.
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Express . . . For the treatment of rheumatoid arthritis, Gilead used priority review vouchers to submit a new jak1 inhibitor application.
Time of Update: 2020-07-23
▎ yaomingkant / report today, Gilead Sciences announced that it has submitted a new drug application (NDA) for Jak1 inhibitor filgtinib to the U.S. FDA for the treatment of adult patients with moderate to severe rheumatoid arthritis.
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Wang Hongyan/Wei Bin collaboration reveals a new mechanism for cholesterol metabolism regulation of innate immune resistance to infection, cellPress dialogue scientists.
Time of Update: 2020-07-23
Viral infection can induce host cells to change the expression of cholesterol metabolizing enzymes and metabolites, and cholesterol metabolism can also regulate the antiviral response of host cells.
recent international frontier work indicates that targeting individual key cholesterol metabolic enzymes and metabolites can improve the function of antiviral infection [1] [2] [3].
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Immunity . . . Wang Hongyan/Wei Bin cooperation reveals a new mechanism for cholesterol metabolism regulation of congenital immune resistance to infection.
Time of Update: 2020-07-23
In the case of viral or bacterial infection, host cells can participate in anti infection through a variety of effective ways. among them, viral infection can induce host cells to change the expressio
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The Tian Zhendong team and collaborators at Huazhong Agricultural University revealed the mechanisms by which two E3 ubiquitin-linked enzyme cascades regulate the plant immune response.
Time of Update: 2020-07-23
many E3 ubiquitin ligases regulate plant immune response positively or negatively by promoting the degradation of their substrates.
the above research system reveals how the two E3 ubiquitin ligases can finely regulate plant immune response through cascading degradation of their respective targets.
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The recent scientific research progress of Huazhong Agricultural University!
Time of Update: 2020-07-23
To reveal the adaptive immune response mechanism of fish oropharyngeal mucosa, recently, Professor Xu Zhen of Fisheries College of Huazhong Agricultural University published "convergent evolution of m
