The recent scientific research progress of Huazhong Agricultural University!

To reveal the adaptive immune response mechanism of fish oropharyngeal mucosa, recently, Professor Xu Zhen of Fisheries College of Huazhong Agricultural University published "convergent evolution of mucosal immune responses at the buccal cavity of teleost fish and pharyngeal immunity in early" in the Journal of immunology In this paper, we found that diffuse oropharyngeal mucosa associated lymphoid tissue existed in early lower vertebrates such as fish, and revealed the molecular mechanism of adaptive immune response in the process of anti infection.the oropharyngeal cavity is the beginning of the respiratory system and digestive system of vertebrates, and is the cavity connecting the body with the outside world.in the process of feeding and breathing, the invasion of pathogenic microorganisms will bring different degrees of threat to the body.studies have shown that the oropharyngeal cavity of higher vertebrates evolves a set of mucosal barrier, which contains mucosa associated lymphoid tissue (MALT), and has a perfect immune protection system, which can effectively protect the body from invasion. In addition, saliva plays an important role in oropharyngeal microecology by secreting SIgA into saliva and combining with pathogenic microorganisms.different from higher mammals, there are no salivary glands in the oropharyngeal mucosa of fish, but there are a large number of mucus secreting cells. Moreover, the molecular immune mechanism of fish oropharyngeal mucosa against infection is still unclear.in order to explore the evolutionary origin of oropharyngeal mucosal immunity and the mechanism of its action in lower vertebrates, Professor Xu Zhen's research group took rainbow trout as the research object, and revealed the existence of diffuse malt in the oropharyngeal mucosa of fish.through further parasite infection, it was found that the oropharyngeal cavity of fish can also produce local natural and adaptive immune response similar to that of mammals.in addition, the research team also found that immunoglobulin IGT plays an important role in the oral mucosa anti infection process. Sigt can transfer to the oropharyngeal mucus through the poly immunoglobulin receptor (pIgR) secreted by epithelial cells to resist the invasion of pathogens.when infected by pathogens, the local proliferation of IGT + B lymphocytes in oropharyngeal mucosa was significant.the results showed that malt existed in the oropharyngeal cavity of non tetrapod for the first time, and played an important role in protecting organism, preventing pathogen invasion and maintaining microbial homeostasis.born in Huazhong Agricultural University, Yongyao and Kong Weiguang are the co first authors of the paper, and Xu Zhen, a professor of Fisheries College, is the corresponding author of the two articles.the research was supported by the national key R & D program and the National Natural Science Foundation of China.new progress has been made in the study of safe production, selenium enrichment dynamics and regulation mechanism of selenium rich rice. Recently, the environmental pollution remediation team of the school of resources and environment of Huazhong Agricultural University published the topics of dynamics of selenium uptake, specialty in international academic journals Science of the total environment and environmental pollution, And antioxidant response in rice at different panicle initiation stages and nitro Oxide Alleviates selenium toxicity in Rice by regulating antioxidation, selenium uptake, speciation and gene expression.the latest progress of safe production and regulation mechanism of selenium rich rice was reported.selenium is an essential micronutrient for human body, which plays an important role in enhancing human immunity, preventing cancer and cancer, and resisting various diseases.nearly 70% of China's population live in soil selenium deficient areas, so it is urgent to supplement selenium scientifically.rice is the main food crop in the world, so it is very important to research and develop selenium rich and safe rice. the results showed that low Se concentration (& lt; 5 mg / kg) promoted rice photosynthesis, improved rice antioxidant capacity and increased rice yield, but high concentration of selenium could cause toxicity. organic forms of SeCys and SeMet were the main selenium forms in rice, and their contents decreased with the increase of selenium treatment level. Under the condition of 10-20mg / kg high selenium treatment, inorganic selenium appeared in brown rice, mainly se (IV) and Se (VI), which may be harmful to human health. according to the results of this study, 0.5-5mg/kg selenium in soil can be used as a safe dose for selenium rich rice production. the mechanism of no alleviating high Se stress in rice was also reported. the results showed that no effectively increased the resistance to selenium stress and alleviated the high selenium toxicity of rice. the main mechanism is to promote rice growth and photosynthesis, increase antioxidant capacity, down regulate the expression of ospt2, ossams1 and ossbp1 genes in roots, down regulate the expression of ospt2, OSCs and ossbp1 genes in shoot, and reduce the absorption and accumulation of selenium in rice. Dai Zhihua, Ph.D. student from the school of resources and environment, Huazhong Agricultural University, is the first author of the paper, and Professor Tu Shuxin is the corresponding author. the research was supported by the Ministry of agriculture's industry special project (201303106) and Guangxi innovation driven development special fund (guike aa17202026). what we share today is only a part of the recent scientific research results of Huazhong Agricultural University.