Tang Dingzhong/Zhou Jianmin co-published the "Plant Immune Signals: Two Frontier Research Progress" review article.

Please click "plant reports" above to follow us! The first time to understand the latest progress in plant science! Recently, jipb published an online review of "plant immune signaling: advancing on two frontiers" by Tang Dingzhong's team and Zhou Jianmin's team from Institute of genetics and developmental biology, Chinese Academy of Sciences.this review summarizes the latest achievements in the field of plant immunity, especially discusses the activation mechanism of PRRS on the surface of plant cell membrane and NLRs protein, dynamic regulation and molecular mechanism of activating downstream immune signals.in this review, the future development trend and challenges in the field of plant immunity were also prospected.plants will be invaded by a variety of pathogenic microorganisms in the whole process of growth and development.in order to resist the invasion of pathogens, plants have evolved two levels of innate immune system.the first level is the PTI immune response triggered by the conservative related molecular mode of pathogens; the second level is the ETI immune response triggered by pathogen effector factors.immune receptor proteins play an indispensable role in the production and transmission of immune signals at these two levels.when pathogens invade, PRRS, which are located on the surface of plant cell membrane, can quickly recognize the conserved components of the pathogen itself and produce a series of immune responses, such as activation of MAPKs cascade signal pathway, activation of calcium dependent protein kinase cpks pathway, outbreak of reactive oxygen species (ROS) and closure of stomata Ti immune response.in this process, the activation and dynamic regulation of PRRS proteins are the key to immune signal generation.at the same time, in order to transmit immune signals, PRRS proteins need to form complexes with downstream acting elements (such as intracellular cytoplasmic receptor like kinase rlcks, etc.).recent research progress has directly linked the production of many PTI reactions with PRRS complexes. This review describes the molecular mechanism of these reactions in detail.in order to inhibit the PTI immune response of plants, some pathogens can secrete effector factors into host cells to make plants susceptible.facing the invasion of pathogens, plants have evolved NLRs, which can recognize effector factors, and activate a stronger immune response, namely ETI immune response.NLRs can be divided into three groups according to their N-terminal variable domains: CNLS, tnls and RNLS.recently, great breakthroughs have been made in the study of NLRs.for example, for the first time, we successfully analyzed the structure of plant full-length CNL protein ZAR1; for the first time, it was found that tnls protein induced programmed cell death depended on NAD + enzyme activity of TIR domain; in addition, NRG1 and ADR1 of RNLS were identified as helper proteins to participate in tnls and CNLS mediated ETI reaction. These important findings were discussed in detail in this review.Dr. Wang Wei of Tang Dingzhong team is the first author of the paper, Professor Feng Baomin of plant immunity center of Fujian agriculture and Forestry University participated in the writing of the paper, and Professor Tang Dingzhong and researcher Zhou Jianmin are co authors. the project is supported by the National Natural Science Foundation of China. is transferred from JIPB official account. please click "read original" in the lower left corner to view the original paper. long press the QR code below to follow plant reports! Pay attention to the latest research progress of agricultural science and plant science!