Yale scientists have developed a new cancer immunotherapy.

|Original compilation, reprint must indicate the source! Photo source: Yale immunotherapy has revolutionized the treatment of cancer, but existing therapies don't work for all patients and don't work for some cancers at all.because it sometimes fails to recognize all the molecular camouflage of cancer cells, it greatly reduces the therapeutic effect.in a new study published in Nature Immunology on October 15, Beijing time, a new system developed by Yale University research team can help the immune system find and eliminate tumors that cannot be recognized by other forms of immunotherapy.in order to solve the problem that existing therapies cannot recognize all the molecular camouflage of cancer cells, Sidi Chen's laboratory, an assistant professor in the Department of genetics and the center for cancer system biology of Yale University, has developed a new system combining viral gene therapy with CRISPR gene editing technology.the new system is called multiplex activation of endogenous genes as immunity (maegi).the new system reduced or eliminated melanoma, triple negative breast and pancreatic tumors in mice, and even eliminated the spread of cancer cells far away from the primary tumor, the researchers said.the new system is not to search and edit DNA fragments and insert new genes, but to activate endogenous genes as immunotherapy, launch a large-scale search for thousands of cancer related genes, and then mark their locations and amplify signals like GPS.Chen said: "this is a new immunotherapy, which can induce anti-tumor immunity through multiple activation of tumor endogenous genes.we used CRISPR to directly enhance the in situ expression of endogenous genes, thus enhancing the expression of tumor antigen, leading to significant anti-tumor immune response."maegi can label tumor cells for immune destruction, thus transforming cold tumors (lack of immune cells) into hot tumors (with immune cells).Chen said this is equivalent to the molecular equivalent of wrapping tumor cells in orange jumpsuits, allowing immune system police to quickly detect and eliminate lethal cells.Image Source: Yale Chen said: "once these cells are recognized, if they appear in the future, the immune system will recognize them immediately."in theory, the new system should be able to effectively treat a variety of cancers, including those currently resistant to immunotherapy.next, they will optimize the system to simplify the manufacturing process and prepare for clinical trials in cancer patients.