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Nature sub-journal: Scientists have mapped the body's immune response to the new coronavirus for the first time.
Time of Update: 2020-07-22
in general, this study provides a new contribution to understanding the breadth and dynamics of the immune response in non severe covid-19 cases.
end reference: [1] doctors map body's coved-19 immune response: study [2] bread of consistent immune responses prior to patient recovery: a case report of non-severe coved-19
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Annual Review of Plant Biology. A review of the evolution of plant NLR immunoreceptor proteins.
Time of Update: 2020-07-22
tip: when adding small wechat and after joining the group, please be sure to note the name of school or unit + at the end of PI, we will invite you to join Pi group.
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Cell . . . Propylene acid slows the development of autoimmune diseases by improving immune regulation and steady state.
Time of Update: 2020-07-22
Supplementation of propionic acid can enhance immune cell function and improve mitochondrial homeostasis, thus delaying the development of multiple sclerosis.
Propionic acid supplementation can activate the function of Treg cells, improve the symptoms of immune disorders and neurodegenerative diseases, which is an effective treatment for autoimmune diseases such as multiple sclerosis Means.
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Cell . . . Lymphoma-driven mutations lead to the production of diseased autoantibodies.
Time of Update: 2020-07-22
through single cell DNA sequencing analysis, lymphoma driven mutation gene can cause abnormal B cells to produce more autoantibodies, leading to the occurrence of pathogenic cryoglobulinemia vasculitis.
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PLOS Pathog: Henan Agricultural Da Baibe/Yang Guoyu and other analysis of BRD4 in the anti-viral natural immunity of the important function.
Time of Update: 2020-07-22
the highlight of this work is the first time to reveal the inhibition of Brd4 to activate antiviral innate immunity through DNA damage dependent CGAs / sting / tbk1 / IRF3 pathway.
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Another mechanism of plant identification of bacterial infection is analyzed! The molecular mechanism of fatty acids produced by bacteria that stimulate plant immune response.
Time of Update: 2020-07-22
On January 10, 2020, the EMBO journal published a research paper entitled tyrosine phosphorylation of the lectin receptor like kinase lore regulations plant immunity by Liu Jun, researcher team of Institute of Microbiology, Chinese Academy of Sciences and center of excellence in biological interaction, reporting the molecular mechanism of plant immune response stimulated by fatty acids produced by bacteria.
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2 in a row. Breakthrough, Tongji University Gobao And others found the host for the new type of mycobacterium tuberculosis immune regulation mechanism.
Time of Update: 2020-07-22
on January 15, 2020, GE Baoxue of Tongji University and Rao Zihe of Shanghai University of science and technology published an online publication entitled "host mediated ubiquitation of a mycobacterial protein suppresses" in nature This study found that host E3 ubiquitin ligase anapc2 (core subunit of late promoter complex / loop) interacts with Mycobacterium protein rv0222, and promotes the attachment of ubiquitin chain of lysine 11 to lysine 76 of rv0222, thus inhibiting the expression of proinflammatory cytokines.
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Nat E. Ni Yu's new team reveals a new mechanism for tumor immunity.
Time of Update: 2020-07-22
on January 13, 2020, Professor Yin Yuxin from the Institute of Systems Biomedicine, Peking University published the title of "the phosphotase PAC1 acts as a T cell suppressor and attenuates host antitumor" in the journal Nature Immunology As a negative regulator of immune system, phosphatase PAC1 can specifically inhibit T lymphocyte defense function and promote tumor immune escape.
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Cancer Cell: Bacteria-derived nanocells can payload cell toxins while stimulating innate and adaptive anti-tumor immune responses.
Time of Update: 2020-07-22
in the new study, the engeneic dream vector (EDV) is introduced ™) The technology can stimulate innate and adaptive immune responses, and describe the strong anti-tumor ability of EDV nanocells and the ability to prolong the remission period of tumors.
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The EMBO Journal: Bacterial free fatty acids stimulate an immune response in plants.
Time of Update: 2020-07-22
On January 10, 2020, the EMBO journal published a research paper entitled "tyrosine phosphorylation of the lore lectin receptor like kinase analogues plant immunity" by Liu Jun, Institute of Microbiology, Chinese Academy of Sciences and center of excellence in biological interaction( DOI:10.15252/embj.2019102856 )The molecular mechanism of plant immune response stimulated by fatty acids carried by bacteria was reported.
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Experts commented on the key role and mechanismof the meninges' lymphatic tubes in anti-brain tumor immunity.
Time of Update: 2020-07-22
on February 25, 2020, Professor Luo Jincai of the Institute of molecular medicine of Peking University and his collaborators published a research paper entitled "meningeal lymphatic vessels regular brain tumor drainage and immunity" in cell research.
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Yan Minhong's team revealed a new tumor immune escape mechanism.
Time of Update: 2020-07-22
The authors suggest that inhibition of the clearance of apoptotic tumor cells by MERTK antibody can increase the release of ATP and cgamp into the tumor microenvironment.
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The Liu Jun Research Group of the Institute of Microbiology reveals a new mechanism for plants to identify pathogenic bacteria.
Time of Update: 2020-07-22
this study revealed that immune receptors on plant cell membranes recognize the medium chain length 3-hydroxyfatty acids carried by pathogenic bacteria, which are important components of lipopolysaccharide (LPS) synthesis.
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The paper's picks that severe peanut allergies may be "intestinal instinctive reactions"; neither natural nor related to parenting: fruit fly sex originates from neurodevelopment.
Time of Update: 2020-07-22
this paper, published in science immunology and accompanied by an article published in the perspective column of science, examined IgE producing B cell samples from intestinal tissues of study participants, who are starting clinical trials of oral peanut protein immunotherapy.
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The prediction of the new coronavirus immune response target promotes effective vaccine design.
Time of Update: 2020-07-22
In January 31, 2020, the novel coronavirus Cell Press bilingual resource center was officially opened.
you can find the contribution policy of covid-19 related papers, as well as the published papers on epidemic situation and virus published in the journals of cell press.
The Chinese official account of novel coronavirus, WeChat public No.
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Nature. Gender differences in Treg cells.
Time of Update: 2020-07-22
In conclusion, this study demonstrated the gender dimorphism of the number and phenotype of Treg cells in visceral adipose tissue of mice, and elaborated the detailed mechanism, which further increased the understanding of the difference of immune response between the two sexes.
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The rheumatism drug treats 14 critically ill patients with new coronary pneumonia.
Time of Update: 2020-07-22
according to Xinhua news agency, academician Zhou Qi, Deputy Secretary General of the Chinese Academy of Sciences, spoke at a press conference of the joint prevention and control mechanism of the State Council on February 15: "researchers are screening some old drugs to inhibit the emergence of inflammatory factor storm, including some drugs that have been proved to be effective in rheumatism and other fields.
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The study reveals a new mechanism of immune to the targeting of lymph nodes.
Time of Update: 2020-07-22
On March 2, Zhu Mingzhao, Key Laboratory of infection and immunity, Institute of Biophysics, Chinese Academy of Sciences, published an article paper in Nature Nanotechnology: dual targeting nanoparticle vaccine elicits a therapeutic antibody response against chronic diseases B.
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New advances in the therapeutic hepatitis B vaccine in Nat Nanotech, Zhu Mingzhao group reveal editing new mechanisms for the targeting of nano-vaccine immunization in lymph nodes.
Time of Update: 2020-07-22
on March 2, 2020, Zhu Mingzhao, Key Laboratory of infection and immunology, Institute of Biophysics, Chinese Academy of Sciences, published a long article "dual targeting nanoparticle vaccine elicits a therapeutic antibody response against chronic diseases B" in Nature Nanotechnology.
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Trends in Immunology , Pasteur Institute uses single-cell sequencing to study animal cell-level immune response, laying the foundation for predicting the spread potential of the virus!
Time of Update: 2020-07-22
in this study, the authors emphasized the need for a better understanding of insect immune responses at organ and cell population levels.