The rheumatism drug treats 14 critically ill patients with new coronary pneumonia.

Novel coronavirus pneumonia is a key inflammatory factor in IL-6.according to Xinhua news agency, academician Zhou Qi, Deputy Secretary General of the Chinese Academy of Sciences, spoke at a press conference of the joint prevention and control mechanism of the State Council on February 15: "researchers are screening some old drugs to inhibit the emergence of inflammatory factor storm, including some drugs that have been proved to be effective in rheumatism and other fields.there are some drugs that have been verified in the early stage and have an effect on the cell level.The First Affiliated Hospital of University of science and technology of China has performed 14 cases of severe and critical patients, the oldest of which is 82 years old. The treatment results of these patients are encouraging.a multicenter randomized controlled trial is being conducted, and more than 100 patients will be enrolled in the study."after the outbreak of Xinguan, the research team of China University of science and technology found that interleukin-6 (IL-6) is an important pathway to induce inflammatory storm. Based on the preliminary understanding of the mechanism, we successfully used" tochizumab "as an inhibitor, and achieved initial clinical effect. Further multi center clinical trials are under way.01. Inflammatory storm, a life-threatening killer inflammatory storm, namely cytokine storm, is an excessive activation of the immune system caused by infection, drugs or some diseases. Once it occurs, it can rapidly cause single organ or multiple organ failure and eventually threaten life.inflammatory storm is an important cause of death in SARS, mers and influenza. In this new outbreak, inflammatory storm is also an important cause of death of many patients.the so-called inflammatory storm is actually caused by the immune system overreaction."when the virus comes, the immune system will throw bombs at them, and the firepower is not enough to control the virus; in another case, the immune system has just recognized the virus, and dropped too many bombs at once, but it has hurt itself."explained Professor Wei.novel coronavirus can enter the cells through angiotensin-converting enzyme 2 (ACE2) after infection. Therefore, high expression of ACE2 and direct contact with the lung tissue outside the body become the main invasion target of the new coronavirus.the lung immune cells are over activated and produce a large number of inflammatory factors, which form inflammatory storm through the mechanism of positive feedback circulation.a large number of immune cells and tissue fluid accumulate in the lung, which can block the gas exchange between alveoli and capillaries, leading to acute respiratory distress syndrome.once an inflammatory storm is formed, the immune system not only kills the virus, but also kills a large number of normal lung cells, which seriously destroys the lung ventilation function. On CT scan of the lung, it shows a large white area, namely "white lung". The patient will suffer from respiratory failure until death due to hypoxia.novel coronavirus and immune cells are also highly expressed in human tissues, heart, kidney, liver and digestive tract. All organs and organs that express ACE2 may be the battlefield of new coronavirus and immune cells, eventually leading to multiple organ failure and life threatening.therefore, finding out the key cytokines of inflammatory storm induced by new coronavirus infection and blocking its signal transduction will greatly reduce the lung tissue and multiple organ damage caused by inflammatory reaction. The novel coronavirus pneumonia outbreak after the outbreak of 02.IL-6, through the support of emergency projects in Anhui and China University of science and technology, Wei Haiming's team moved the laboratory to the affiliated hospital infection area for the first time, and launched joint research with Xu Xiaoling's chief physician team. there are countless immune molecules. Which one is the key factor leading to the inflammatory storm? This is the key problem faced by Wei Haiming's team. Professor Wei Haiming works in the biosafety laboratory. The novel coronavirus pneumonia novel coronavirus infection was the novel coronavirus infection mechanism. The Wang Dongsheng photographic research team analyzed the 30 blood immunological parameters of 33 new crown pneumonia patients, and discovered the key mechanism of severe coronavirus infection severe inflammatory pneumonia storm. After the new coronavirus infection, the pathogenic T cells were activated rapidly, and the granulocyte macrophage colony stimulating factor GM-CSF and IL-6 were produced. GM-CSF can further activate CD14 + CD16 + inflammatory monocytes, produce more IL-6 and other inflammatory factors, thus forming an inflammatory storm, leading to severe lung and other organ immune damage. novel coronavirus pneumonia and IL-6 are the two inflammatory factors that cause inflammation in the patients with new crown pneumonia. The announcement of the novel coronavirus pneumonia diagnostic and therapeutic plan for severe and severe cases (trial version second) issued by the office of the national health and Health Committee and the office of the State Administration of traditional Chinese medicine in February 14th has clearly made the IL-6 progressive rise as a clinical warning indicator for the deterioration of the disease. The novel coronavirus pneumonia novel coronavirus novel coronavirus pneumonia is a new drug for the treatment of severe pneumonia. The team speculated that the anti IL-6 receptor monoclonal antibody, "
03.IL-6", could block the inflammatory storm of the new crown pneumonia and quickly formulated a new treatment plan of "monumab plus conventional therapy". 。 the first recombinant humanized monoclonal antibody against IL-6 receptor in the world is a first-line drug for the treatment of autoimmune diseases (such as rheumatoid arthritis) with elevated IL-6. in 2017, the U.S. Food and Drug Administration (FDA) expanded the indications for tochizumab, including the treatment of cytokine release syndrome (cytokine storm) caused by car-t cell therapy. the research team carried out clinical trials according to the new treatment plan, and the results of the first stage basically verified the team's explanation of the mechanism of inducing inflammatory storm. novel coronavirus pneumonia in 14 clinical cases (maximum age 82 years, male 12 cases, female 2 cases, 9 cases of severe cases, 2 cases of critical illness), two lung diffuse lesions before treatment, 11 cases of continuous fever. the new treatment scheme of "tochizumab + conventional treatment" was used. at present, the body temperature of 11 patients with fever fell to normal within 24 hours, and has been stable up to now, lasting for 9 days at most; the oxygenation index of respiratory function has been improved in varying degrees; the absorption of lung CT lesions in 4 patients has improved, and 1 patient with critical endotracheal intubation has been successfully offline. the existing clinical data suggest that this new treatment may block the inflammatory storm and prevent the patients from turning into severe and critical illness and reduce the death rate. the multi center research project of inflammatory storm has been officially established on February 6, 2020. at present, five hospitals have joined the multi center clinical research, and gradually expand to the disaster areas. Doctor Zhang Dingyu, President of Wuhan Jinyintan hospital, said that the treatment of critically ill patients is a great bottleneck, so far there is still no good treatment. novel coronavirus pneumonia is also being used to prevent the progression of severe acute respiratory syndrome to the early onset of pneumonia. this article is organized from Xinhua news agency, official website of China University of science and technology, China Biotechnology website, and China Science Journal. Editor: Fenghe responsible editor: Fenghe end love me, please give me a good look!