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Wu Qingfa team found a new mechanism of natural immunity mediated by long non-coding RNA.
Time of Update: 2020-07-22
on January 8, 2020, Professor Wu Qingfa, School of life, University of science and technology of China published an article lncrna sensing of a viral suppressor of RNAi activates non canonical innate immune signaling in the journal Cell Host microbe Drosophila, for the first time, reported that the host perceives the viral VSR through long noncoding RNA, and then activates a new nonclassical innate immune pathway.
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A war without smoke, the immune system of small plants.
Time of Update: 2020-07-22
NLR receptors located in cells can directly or indirectly recognize effectors and make plants make a second layer of immune response, which is called ETI (effector triggered immunity).
ETI and PTI induce similar immune responses [5] the interaction of PRRS and NLR can make plants resist the infection of most pathogens.
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Cell reveals the root causes of autoimmune diseases: the original "rogue" immune cells are screwing up.
Time of Update: 2020-07-22
the evolution of the disease, researchers found that the pathogenic immune cells of patients with vasculitis had accumulated a large number of mutations before the production of rheumatoid factor.
moreover, some of the initial gene mutations that occur in these rogue cells can cause lymphoma (immune cell canceration).
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How is folate levels associated with the risk of death in RA patients? Can metformin treat SLE? A week of wind and clouds.
Time of Update: 2020-07-22
Serum folic acid levels are associated with cardiovascular death risk in RA patients.
that is to say, when the serum folic acid level of RA patients is not lower than 4.3 ng / ml, the risk of cardiovascular death will be reduced.
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Cell . . . Multi-functional antibodies that target NKp46 activate the anti-tumor immunity of NK cells.
Time of Update: 2020-07-22
recently, Eric Vivier and Laurent Gauthier from France published a paper on cell entitled multifunctional natural killer cell engagers targeting NKp46 trigger protective tumor immunity, which reported three functional nature killer cell engagers targeting NK activated receptors NKp46, CD16 and tumor antigen Nkces can activate NK cells, control the growth of solid tumors and invasive tumors, and have the pharmacokinetics similar to IgG antibody, and have no off target effect.
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Major Discoveries . . . The Lu Jiahai team at Sun Yat-sen University has revealed that anti-SARS-CoV antibodies can be present for at least 12 years and may have an immune effect on coronaviruses such as 2019-nCoV.
Time of Update: 2020-07-22
it is worth noting that 2019 ncov is very similar to severe acute respiratory syndrome coronavirus (SARS CoV), characterized by high mortality and infectivity.
in this study, 34 medical staff with SARS CoV infection were followed up for 13 years.
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Nature Sub-Journal: The new team of YuYu Yu of Peking University has revealed a new mechanism for cancer immunity.
Time of Update: 2020-07-22
in 2003, Professor Yin Yuxin's research group reported for the first time that PAC1 was involved in the occurrence and development of tumors in nature, and proposed that PAC1, as a phosphatase specifically expressed in the immune system, may participate in the formation and remodeling of tumor microenvironment.
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Nature's Gobbo/RaoZi and the team revealed new mechanisms for TB escape and immunity against TB.
Time of Update: 2020-07-22
Tuberculosis (TB) is caused by Mycobacterium tuberculosis (MTB) infection. It is one of the most widespread bacterial diseases in the world. It is still one of the top ten causes of death in the world
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The Liu Jun Research Group of the Institute of Microbiology reveals a new mechanism for plants to identify pathogenic bacteria.
Time of Update: 2020-07-22
this study revealed that immune receptors on plant cell membranes recognize the medium chain length 3-hydroxyfatty acids carried by pathogenic bacteria, which are important components of lipopolysaccharide (LPS) synthesis.
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New advances in the therapeutic hepatitis B vaccine in Nat Nanotech, Zhu Mingzhao group reveal editing new mechanisms for the targeting of nano-vaccine immunization in lymph nodes.
Time of Update: 2020-07-22
on March 2, 2020, Zhu Mingzhao, Key Laboratory of infection and immunology, Institute of Biophysics, Chinese Academy of Sciences, published a long article "dual targeting nanoparticle vaccine elicits a therapeutic antibody response against chronic diseases B" in Nature Nanotechnology.
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Cell . . . Propylene acid slows the development of autoimmune diseases by improving immune regulation and steady state.
Time of Update: 2020-07-22
Supplementation of propionic acid can enhance immune cell function and improve mitochondrial homeostasis, thus delaying the development of multiple sclerosis.
Propionic acid supplementation can activate the function of Treg cells, improve the symptoms of immune disorders and neurodegenerative diseases, which is an effective treatment for autoimmune diseases such as multiple sclerosis Means.
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The rheumatism drug treats 14 critically ill patients with new coronary pneumonia.
Time of Update: 2020-07-22
according to Xinhua news agency, academician Zhou Qi, Deputy Secretary General of the Chinese Academy of Sciences, spoke at a press conference of the joint prevention and control mechanism of the State Council on February 15: "researchers are screening some old drugs to inhibit the emergence of inflammatory factor storm, including some drugs that have been proved to be effective in rheumatism and other fields.
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Nature. Gender differences in Treg cells.
Time of Update: 2020-07-22
In conclusion, this study demonstrated the gender dimorphism of the number and phenotype of Treg cells in visceral adipose tissue of mice, and elaborated the detailed mechanism, which further increased the understanding of the difference of immune response between the two sexes.
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Science . . . A panoramic view of plant immune response triggered by effect factors.
Time of Update: 2020-07-22
the researchers further screened NLRs related to 19 ETI elicitor families in Arabidopsis thaliana, expressed each ETI elicitor in DC3000, then infected different NLR mutant plants, confirmed the corresponding relationship in ETI response through phenotypic experiment, and finally identified the NLR protein that can be induced by all ETI elicitors.
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How does the influenza virus, which kills hundreds of thousands of people around the world in silence every year, escape the recognition of the body's immune system?
Time of Update: 2020-07-22
this study reports the biological effects of influenza virus NS1 protein binding to host receptor protein RIG-I, which directly eliminates the alarm of activating cellular innate immunity.
this study highlights the importance of how mutations in the NS1 protein of influenza virus strains affect their ability to respond to host cell immunity.
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Nature. A new immune mechanism that regulates fat sympathetic nerves and heat production.
Time of Update: 2020-07-22
In particular, in heat source adipose tissue, γ δ T cells and il-17rc jointly regulate sympathetic innervation and thermogenesis through TGF β 1 pathway.
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See only the elderly? Pain is hallucinations? You have these three misconceptions about fibromyalgia!
Time of Update: 2020-07-22
For some people with fibromyalgia syndrome, the pain may be very serious, accompanied by fatigue, sleep disorders, morning stiffness, depression, anxiety and other mental symptoms, greatly reduce the quality of life of patients, and even affect the normal study, work and life.
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What are the effects of short-term deactivation of methotrexate on disease activity in RA patients? Which type of RA patient is more likely to quit smoking?
Time of Update: 2020-07-22
What are the effects of short-term discontinuation of methotrexate on disease activity in patients with rheumatoid arthritis?
the researchers indicated that it was safe to discontinue methotrexate for 2 weeks, while withdrawal for 4 weeks might increase the risk of disease activity in RA patients.
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The memory B cells are cloned bottlenecks during the Cell-secondary immune response - old ideas for vaccine design or changes.
Time of Update: 2020-07-22
it has to be said that a thorough understanding of the rules governing GC re-entry of memory B cells is important for any attempt to induce amplification and high-frequency mutation of B-cell clones with specific characteristics by repeatedly recalling MBCs into continuous GC reactions, just as it is believed that vaccination is needed to produce generalized neutralizing antibodies (bnabs) against influenza and HIV Like.
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Immunity . . . Li Xiaoxue and others reveal how fruit flies cope with THE accumulation of ROS in the body.
Time of Update: 2020-07-22
in this paper, the authors used Drosophila melanogaster as a model, and found that pathogen infection or tissue damage could lead to the excretion of lipids from haemolymph (insect blood) by the Malpighian tubules (insect kidney).