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Does the intestinal flora aggravate osteoarthritis? Cyclophosphamide cures disease or causes cancer? A week of "wind" clouds.
Time of Update: 2020-07-22
in a study involving 1427 patients with OA, the relative and absolute abundance of Streptococcus species in fecal microbiota samples were associated with the severity of OA disease and the increased knee pain associated with OA.
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The Lancet Sub-Journal: New Uses of Metformin? It is expected to improve metabolic health in patients with chronic inflammation.
Time of Update: 2020-07-22
in phase 2 clinical trials, metformin can improve metabolic health and reduce the serious side effects of glucocorticoid treatment in patients with chronic inflammatory diseases.
Image Source: pixabay based on these studies, the research team of Queen Mary University in London led the phase II clinical trial of this randomized, double-blind, placebo-controlled, proof of concept.
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A randomized trial for the treatment of gout by epwhoseine and autumn daffodils was compared.
Time of Update: 2020-07-22
in the UK trial, 399 patients with acute gout were randomly assigned to either the naproxen group (initial dose 750 mg; followed by 250 mg tid for 1 week) or the colchicine group (0.5 mg tid for 4 days).
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Cell . . . The intestinal nervous system participates in the mucous membrane immune barrier by secreting IL18.
Time of Update: 2020-07-22
previous studies have deeply analyzed the important role of the interaction between epithelial cells and immune system in maintaining intestinal homeostasis in intestinal tissues, but how ens and epithelial cells interact, what are the mediators, and what is the mode of action are still unknown.
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What are the commongines? What do I need to pay attention to when taking medication?
Time of Update: 2020-07-22
the drugs for the treatment of hyperuricemia and gout are mainly the drugs for inhibiting the production of uric acid (allopurinol, febuxostat, etc.), promoting the excretion of uric acid (benzbromarone, etc.), uric acid oxidase (labilise, prekexil, pegolose), alkalizing urine drugs (sodium bicarbonate, citrate preparation), drugs for acute gout attack (non steroidal anti-inflammatory drugs, Qiushui) In addition, there was no significant difference between the two groups.
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A new regulatory mechanism of innate immunity of plants.
Time of Update: 2020-07-22
in conclusion, our results elucidate a new regulatory mechanism that PLD δ is transported through the exocytosis pathway, which helps plants to perform penetrating defense responses against fungal pathogens.
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How does the body's immune system protect itself when a new coronavirus invades? The SARS-CoV-2 immune response is that things.
Time of Update: 2020-07-22
in this process, macrophages recognize antigens and phagocytize the components of the host's innate immune system, and detect virus infection by using pattern recognition receptors (PRRS) to recognize pathogen related molecular patterns (PAMPs) · Immature dendritic cells (DCS) have a strong ability to phagocytize antigens.
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Viela Bio targets CD40 antibodies domestically declared clinically.
Time of Update: 2020-07-22
vib4920 is an antibody like drug targeting CD40, which is made of Tn3 scaffold fusion protein that specifically binds to CD40.
viela bio is committed to developing new mechanisms of autoimmune drugs to meet clinical needs.
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Express . . . The positive results of the long-term trial of the first immunotherapy in patients with peanut allergy were positive.
Time of Update: 2020-07-22
taking palforzia for a long time can not only make peanut allergy patients continue to desensitize to peanut protein, but also improve their quality of life.
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Tsinghua University and other units for the first time found the immunological characteristics of the newly recovered patients.
Time of Update: 2020-07-22
on March 20, 2020, Dong Chen team of Institute of immunology of Tsinghua University, Chen Fang team of Chuiyangliu Hospital Affiliated to Tsinghua University and Qin Chengfeng team of Academy of Military Medical Sciences published a research paper entitled "characterization of anti-virus immunity in recovered individuals affected by sars-cov-2" in medrxiv.
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Zhang Xiaoyan/Jun-O Jin team found that new adjuzers can be used in tumor immunotherapy.
Time of Update: 2020-07-22
on March 4, 2020, the Co-PI jun-o Jin group of Co-PI jun-o Jin team, Shanghai Public Health Clinical Center affiliated to Fudan University and Biomedical Research Institute of Fudan University, published an online paper on nature communications The adjuvant effect of E.coli adhesin FimH in cancer immunotherapy was revealed in mice and human peripheral blood cells, providing a new candidate for adjuvant in cancer immunotherapy.
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Science Advances . . . Breakthrough, Zhejiang University Tang Ruikang / Wang Ben developed a universal panda blood, is expected to solve the problem of rare blood type blood transfusion.
Time of Update: 2020-07-22
on March 21, 2020, Tang Ruikang and Wang Ben of Zhejiang University published a joint communication entitled "surface anchored framework for generating RHD epitope steady red blood" Cells "research paper, which is designed to produce RhD negative RBC through the three-dimensional (3D) cross-linked skeleton of a rational design of polysialic acid (PSA) tyramine hydrogel to produce negative RBC, has a flexible texture to ensure cell membrane stability.
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Is the "Rheuphys Ivy" indicator positive is rheumatic disease? Wrong!
Time of Update: 2020-07-22
at 4-6 weeks after infection, Aso increased in 80% of patients with rheumatic fever, often accompanied by rapid ESR and leukocytosis, which is helpful for differential diagnosis.
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Latest! China's systematic lupus diagnosis and treatment guidelines issued, these 12 updates a text to master! Guide time.
Time of Update: 2020-07-22
Stamp "read the original text" and check the original guide! Systemic lupus erythematosus (SLE) is a systemic autoimmune disease, its diagnosis and treatment are very complex. it is imperative to form
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Is this case of multiple skin loss and mucosa affected by the patient, is white plug disease?
Time of Update: 2020-07-22
2017.02.009) diagnosis: combined with the morphology and distribution of skin mucosal lesions, laboratory examination and pathological examination, the final diagnosis was chronic lichenoides (keratosis lichenoides) chronica,KLC)。 treatment: Isotretinoin 40mg / D, skin rash was significantly improved, but oral ulcer and eyelid conjunctivitis were not improved.
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Nature sub-issue: The immune system calls you to eat on time! Scientists have found that the gut's inherent immune function increases at the time of eating, preventing the infection of the eating pathogen.
Time of Update: 2020-07-22
in this week, the circadian rhythm of mice had not changed significantly, but at T4, compared with the day eating mice who had just started eating, the ilc3 of the mice who had just eaten at night was significantly more active, and the proportion of cells secreting IL-22 was about 2 times higher.
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Express . . . Treatment of rare immune diseases, precision anti-cancer therapy Phase 2 data positive.
Time of Update: 2020-07-22
▎ today, blueprint medicine announced that its oral kit and pdapritinib, an oral inhibitor of PDGFR α, have significantly improved the comprehensive symptoms of patients with systemic mastocytosis (SM) in the phase II clinical trial of Pioner in the treatment of systemic mastocytosis (SM).
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Science . . . A panoramic view of plant immune response triggered by effect factors.
Time of Update: 2020-07-22
the researchers further screened NLRs related to 19 ETI elicitor families in Arabidopsis thaliana, expressed each ETI elicitor in DC3000, then infected different NLR mutant plants, confirmed the corresponding relationship in ETI response through phenotypic experiment, and finally identified the NLR protein that can be induced by all ETI elicitors.
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What are the effects of short-term deactivation of methotrexate on disease activity in RA patients? Which type of RA patient is more likely to quit smoking?
Time of Update: 2020-07-22
What are the effects of short-term discontinuation of methotrexate on disease activity in patients with rheumatoid arthritis?
the researchers indicated that it was safe to discontinue methotrexate for 2 weeks, while withdrawal for 4 weeks might increase the risk of disease activity in RA patients.
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How does the influenza virus, which kills hundreds of thousands of people around the world in silence every year, escape the recognition of the body's immune system?
Time of Update: 2020-07-22
this study reports the biological effects of influenza virus NS1 protein binding to host receptor protein RIG-I, which directly eliminates the alarm of activating cellular innate immunity.
this study highlights the importance of how mutations in the NS1 protein of influenza virus strains affect their ability to respond to host cell immunity.