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Nature. A new immune mechanism that regulates fat sympathetic nerves and heat production.
Time of Update: 2020-07-22
In particular, in heat source adipose tissue, γ δ T cells and il-17rc jointly regulate sympathetic innervation and thermogenesis through TGF β 1 pathway.
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Is this case of multiple skin loss and mucosa affected by the patient, is white plug disease?
Time of Update: 2020-07-22
2017.02.009) diagnosis: combined with the morphology and distribution of skin mucosal lesions, laboratory examination and pathological examination, the final diagnosis was chronic lichenoides (keratosis lichenoides) chronica，KLC）。 treatment: Isotretinoin 40mg / D, skin rash was significantly improved, but oral ulcer and eyelid conjunctivitis were not improved.
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Zhang Xiaoyan/Jun-O Jin team found that new adjuzers can be used in tumor immunotherapy.
Time of Update: 2020-07-22
on March 4, 2020, the Co-PI jun-o Jin group of Co-PI jun-o Jin team, Shanghai Public Health Clinical Center affiliated to Fudan University and Biomedical Research Institute of Fudan University, published an online paper on nature communications The adjuvant effect of E.coli adhesin FimH in cancer immunotherapy was revealed in mice and human peripheral blood cells, providing a new candidate for adjuvant in cancer immunotherapy.
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Rheumatic stomatism these drugs should be careful! Waist thickening, knee osteoarthritis may worsen? A week of wind and clouds.
Time of Update: 2020-07-22
for patients with knee osteoarthritis, there is a risk of decreased physical function in the second year after the increase in waist circumference, which may be reduced by maintaining the waist circumference, according to the researchers.
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Latest! China's systematic lupus diagnosis and treatment guidelines issued, these 12 updates a text to master! Guide time.
Time of Update: 2020-07-22
Stamp "read the original text" and check the original guide! Systemic lupus erythematosus (SLE) is a systemic autoimmune disease, its diagnosis and treatment are very complex. it is imperative to form
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What are the commongines? What do I need to pay attention to when taking medication?
Time of Update: 2020-07-22
the drugs for the treatment of hyperuricemia and gout are mainly the drugs for inhibiting the production of uric acid (allopurinol, febuxostat, etc.), promoting the excretion of uric acid (benzbromarone, etc.), uric acid oxidase (labilise, prekexil, pegolose), alkalizing urine drugs (sodium bicarbonate, citrate preparation), drugs for acute gout attack (non steroidal anti-inflammatory drugs, Qiushui) In addition, there was no significant difference between the two groups.
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Science . . . A panoramic view of plant immune response triggered by effect factors.
Time of Update: 2020-07-22
the researchers further screened NLRs related to 19 ETI elicitor families in Arabidopsis thaliana, expressed each ETI elicitor in DC3000, then infected different NLR mutant plants, confirmed the corresponding relationship in ETI response through phenotypic experiment, and finally identified the NLR protein that can be induced by all ETI elicitors.
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Viela Bio targets CD40 antibodies domestically declared clinically.
Time of Update: 2020-07-22
vib4920 is an antibody like drug targeting CD40, which is made of Tn3 scaffold fusion protein that specifically binds to CD40.
viela bio is committed to developing new mechanisms of autoimmune drugs to meet clinical needs.
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Sci Adv . . . Xu Wenyue's team reveals new mechanisms for malaria parasite immunity.
Time of Update: 2020-07-22
Malaria is one of the three most serious infectious diseases in the world. There are nearly 200 million malaria cases and 450000 deaths in the world every year. although the discovery of the antimalar
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See only the elderly? Pain is hallucinations? You have these three misconceptions about fibromyalgia!
Time of Update: 2020-07-22
For some people with fibromyalgia syndrome, the pain may be very serious, accompanied by fatigue, sleep disorders, morning stiffness, depression, anxiety and other mental symptoms, greatly reduce the quality of life of patients, and even affect the normal study, work and life.
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The memory B cells are cloned bottlenecks during the Cell-secondary immune response - old ideas for vaccine design or changes.
Time of Update: 2020-07-22
it has to be said that a thorough understanding of the rules governing GC re-entry of memory B cells is important for any attempt to induce amplification and high-frequency mutation of B-cell clones with specific characteristics by repeatedly recalling MBCs into continuous GC reactions, just as it is believed that vaccination is needed to produce generalized neutralizing antibodies (bnabs) against influenza and HIV Like.
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Immunity . . . Li Xiaoxue and others reveal how fruit flies cope with THE accumulation of ROS in the body.
Time of Update: 2020-07-22
in this paper, the authors used Drosophila melanogaster as a model, and found that pathogen infection or tissue damage could lead to the excretion of lipids from haemolymph (insect blood) by the Malpighian tubules (insect kidney).
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How does the body's immune system protect itself when a new coronavirus invades? The SARS-CoV-2 immune response is that things.
Time of Update: 2020-07-22
in this process, macrophages recognize antigens and phagocytize the components of the host's innate immune system, and detect virus infection by using pattern recognition receptors (PRRS) to recognize pathogen related molecular patterns (PAMPs) · Immature dendritic cells (DCS) have a strong ability to phagocytize antigens.
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Express . . . The positive results of the long-term trial of the first immunotherapy in patients with peanut allergy were positive.
Time of Update: 2020-07-22
taking palforzia for a long time can not only make peanut allergy patients continue to desensitize to peanut protein, but also improve their quality of life.
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Tsinghua University and other units for the first time found the immunological characteristics of the newly recovered patients.
Time of Update: 2020-07-22
on March 20, 2020, Dong Chen team of Institute of immunology of Tsinghua University, Chen Fang team of Chuiyangliu Hospital Affiliated to Tsinghua University and Qin Chengfeng team of Academy of Military Medical Sciences published a research paper entitled "characterization of anti-virus immunity in recovered individuals affected by sars-cov-2" in medrxiv.
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The Lancet Sub-Journal: New Uses of Metformin? It is expected to improve metabolic health in patients with chronic inflammation.
Time of Update: 2020-07-22
in phase 2 clinical trials, metformin can improve metabolic health and reduce the serious side effects of glucocorticoid treatment in patients with chronic inflammatory diseases.
Image Source: pixabay based on these studies, the research team of Queen Mary University in London led the phase II clinical trial of this randomized, double-blind, placebo-controlled, proof of concept.
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A new regulatory mechanism of innate immunity of plants.
Time of Update: 2020-07-22
in conclusion, our results elucidate a new regulatory mechanism that PLD δ is transported through the exocytosis pathway, which helps plants to perform penetrating defense responses against fungal pathogens.
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What are the effects of short-term deactivation of methotrexate on disease activity in RA patients? Which type of RA patient is more likely to quit smoking?
Time of Update: 2020-07-22
What are the effects of short-term discontinuation of methotrexate on disease activity in patients with rheumatoid arthritis?
the researchers indicated that it was safe to discontinue methotrexate for 2 weeks, while withdrawal for 4 weeks might increase the risk of disease activity in RA patients.
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Science Advances . . . Breakthrough, Zhejiang University Tang Ruikang / Wang Ben developed a universal panda blood, is expected to solve the problem of rare blood type blood transfusion.
Time of Update: 2020-07-22
on March 21, 2020, Tang Ruikang and Wang Ben of Zhejiang University published a joint communication entitled "surface anchored framework for generating RHD epitope steady red blood" Cells "research paper, which is designed to produce RhD negative RBC through the three-dimensional (3D) cross-linked skeleton of a rational design of polysialic acid (PSA) tyramine hydrogel to produce negative RBC, has a flexible texture to ensure cell membrane stability.
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How does the influenza virus, which kills hundreds of thousands of people around the world in silence every year, escape the recognition of the body's immune system?
Time of Update: 2020-07-22
this study reports the biological effects of influenza virus NS1 protein binding to host receptor protein RIG-I, which directly eliminates the alarm of activating cellular innate immunity.
this study highlights the importance of how mutations in the NS1 protein of influenza virus strains affect their ability to respond to host cell immunity.
