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Nature. A new immune mechanism that regulates fat sympathetic nerves and heat production.
Time of Update: 2020-07-22
In particular, in heat source adipose tissue, γ δ T cells and il-17rc jointly regulate sympathetic innervation and thermogenesis through TGF β 1 pathway.
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Systemic lupus patients, what are the characteristics of men and women?
Time of Update: 2020-07-21
Is gender related to the clinical manifestations and prognosis of systemic lupus erythematosus?
There is a significant gender difference in incidence.
Comparison of clinical characteristics of male and female patients with systemic lupus erythematosus in child-bearing age.
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Suffering from "rheumatoid arthritis" for 2 years, 26-year-old I almost died suddenly. Wind list is finalized.
Time of Update: 2020-07-21
some scholars believe that the increased risk of acute coronary syndrome (ACS) in SLE patients is associated with obesity, dyslipidemia, hypertension, type 2 diabetes, sedentary lifestyle, male, smoking, old age, hyperhomocysteinemia, renal insufficiency, family history of coronary heart disease and antiphospholipid antibodies.
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B-cell critical pathways open a new era in lupus targeted therapy.
Time of Update: 2020-07-21
baileyumab can be used in the treatment of systemic lupus erythematosus, which can control disease activity, reduce hormone dosage and recurrence risk, reduce organ damage, and its safety is similar to placebo.
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Immunity . . . Dong Chen/Chen Fang/Qin Chengfeng found that patients recovering from new coronary pneumonia can produce specific antibodies against the new coronavirus.
Time of Update: 2020-07-21
in general, this study provides a basis for further analysis of protective immunity against sars-cov-2 and for understanding the pathogenesis of covid-19, especially in severe cases.
this study provides a basis for further analysis of protective immunity against sars-cov-2 and for understanding the pathogenesis of covid-19, especially in severe cases.
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Inflammation, fat deposition and new bone formation: the mystery of the structural progression of strong straight spina bifida.
Time of Update: 2020-07-21
several MRI studies have confirmed that during the follow-up of axspa patients, the changes of "inflammation → fat deposition → new bone formation" can be observed from MRI and X-ray examination results over time.
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Immunity . . . The cooperation between Gao Yimeng/Li Huabing and others reveals the important role of m6A in natural immunity and hematopoietic development.
Time of Update: 2020-07-21
In higher mammals, RNA, as an intermediate carrier of genetic material, has been a research hotspot in various fields, including alternative splicing, post transcriptional processing, translation init
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EULAR 2020 Wonderful Express: Anti-TNF-alpha Monotatre Latest Progress to see first!
Time of Update: 2020-07-21
the results of several studies published in this eular2020 confirmed that the long-term withdrawal rate of golimumab is low, and the drug retention rate is relatively high, which is conducive to the long-term stable treatment of patients with rheumatic immune disease.
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Does methotrexate not increase the risk of RA lung disease? These "lung care" methods are known to know about the seULAR 2020.
Time of Update: 2020-07-21
an oral report at the 2020 EULAR annual meeting (Abstract: 0p0035) [4] included 8963 RA patients diagnosed from the discussion analytics jointman database to assess the epidemiological and clinical characteristics of rheumatoid arthritis with interstitial lung disease (ra-ild).
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"Promotions" in clinical guidelines recommended by Treasury
Time of Update: 2020-07-21
in 2016, in the management guidelines for axial spondyloarthritis (axspa) published by ASAS / EULAR [1], patients with as who are still at disease activity after NSAIDs treatment and patients who fail TNF inhibitor (tnfi) treatment can choose IL-17 inhibitors for treatment (A-level Recommendation / evidence level 1b, figure 1).
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Science Back-to-Back . . . Natural immunity or DNA vaccine immunity can provide effective memory immunity protection for rhesus monkey SARS-CoV-2 reinfection.
Time of Update: 2020-07-21
it is important that the specific antibody and cellular immune responses of sars-cov-2 were observed in all rhesus monkeys on the 35th day, and the T cell response of the high-dose group was more intense.
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Express . . . Lilly IL-17A inhibitors have been approved by the FDA for the treatment of mid-axis spinal arthritis.
Time of Update: 2020-07-21
Lilly, editor of the content team of Wuxi apptec, announced today that the US FDA has approved the extended indications of taltz (ixekizumab), an IL-17A antagonist developed by the company, for the treatment of patients with active non radiologic axial spondylitis (NR axspa) with objective inflammatory symptoms.
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Nature. The mechanism by which autophagy promotes immune escape for pancreatic cancer.
Time of Update: 2020-07-21
Kimmelman of New York University School of medicine in nature In PDAC, we report that nbr1, an autophagic cargo receptor protein, targets and selects MHC-I molecules on the cell surface and downregulates MHC-I through autophagy dependent lysosomal degradation pathway.
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There have been "Reynolds phenomenon", is sudden lower limb numbness, urination difficulties, this is the dragonfly?
Time of Update: 2020-07-21
Figure 1 physical examination showed swelling of hands, ulcer of fingertips, patchy brown rash and pigmentation on both lower limbs.
Fig. 2 pathological biopsy of skin rash ▎ immunological indexes are as follows: correct answer: mixed connective tissue disease (MCTD).
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More than 15% of rheumatic clinics are seeing this? The focus of the diagnosis and treatment once clear!
Time of Update: 2020-07-21
Professor Daniel clausw pointed out: FMS is a kind of disease caused by abnormal amplification of "volume" of central pain processing regulator.
Professor Daniel clausw pointed out that in clinical practice, many doctors ignore the screening of FMS when they are faced with chronic pain patients with certain primary diseases, resulting in patients receiving wrong treatment.
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Worried about knee osteoarthritis, try these exercises?!
Time of Update: 2020-07-21
Alison Chang, the author of the study, said: "our findings convey a welcome message that people at high risk of knee OA can safely engage in moderate intensity long-term vigorous exercise to improve their overall health.
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EULAR heavy lupus research interpretation , biological agents to treat lupus nephritis future has come.
Time of Update: 2020-07-21
Professor Zhang Fengchun, chairman of the conference and director of the Department of internal medicine of Peking Union Medical College Hospital, introduced: "six years ago, a Northeast Asian Study of 500 patients with baileyumab also showed that the drug can reduce the double stranded DNA level and increase the complement level of lupus patients, and the symptoms of LN patients have been improved, and the hormone dose is reduced.
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Cell Res . . . Breakthrough, Wuhan University's zhongbo team found that ubiquitin adjusts the stability of cGAS and promotes cellular antiviral response and autoimmune.
Time of Update: 2020-07-21
therefore, the findings reveal the key role of usp29 in innate antiviral response to DNA viruses and autoimmune diseases, and provide insights into the regulation of CGAs. the innate immune response to viral infection is triggered by pattern recognition receptors (PRRS), including toll like receptors (TLRs), RIG-I-like receptors and cytoplasmic DNA sensors.
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Plant Cell. A new mechanism for the control of immunity in plant pores.
Time of Update: 2020-07-21
In conclusion, sif2 participates in ABA and flg22 mediated stomatal closure through interaction and phosphorylation with the anion channel slac1 of guard cells, thus playing a key role in stomatal immunity of plants to bacteria.
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The Team Dong Chen of Tsinghua University and others reported in Immunity on the body fluids and cell immunity caused by the new coronavirus.
Time of Update: 2020-07-21
This article is reprinted by emmeck, source: Center for advanced innovation in structural biology, May 6, 2020 / emedclub news News / - the team of Dong Chen (cooperative PI), the team of Chen Fang of