Worried about knee osteoarthritis, try these exercises?!

A week of wind and cloud, waiting for you to see! Knee osteoarthritis high-risk groups, strenuous exercise can also?! People at high risk for knee osteoarthritis (OA) may be reluctant to participate in strenuous physical activities, such as jogging, cycling, tennis and skiing.but a 10-year study of high-risk people in the northwest of the United States shows that these strenuous exercises do not increase their risk of knee OA, and may even protect them from knee OA.Alison Chang, the author of the study, said: "our findings convey a welcome message that people at high risk of knee OA can safely engage in moderate intensity long-term vigorous exercise to improve their overall health."according to the Centers for Disease Control and prevention, OA is the most common joint disease in the United States, affecting 32.5 million adults, of which the knee is the most frequently involved joint.overweight, history of joint injury or surgery, aging and chronic knee symptoms increase the risk of knee OA.although regular physical exercise and fitness can bring a variety of health benefits, it is still uncertain whether intensive physical exercise will cause pain and further tissue damage.this study analyzed data on 1194 people (aged 45-79 years) from four communities in the United States at risk or increased risk of knee arthritis.during a 10-year follow-up, subjects underwent X-ray examination of both knees to determine the status of OA disease of the knee, and reported their weekly strenuous physical activity and sitting posture.This observational study found that long-term physical activity was not associated with the risk of knee OA (as diagnosed by imaging).Alison Chang said: "adults at high risk of knee OA can safely engage in moderate intensity long-term strenuous exercise."in addition, the researchers' analysis showed that 50% of the high-risk groups of knee OA were those who had not engaged in any strenuous physical activity in eight years.in the treatment of Sjogren's syndrome, this method is worth trying! Primary Sjogren's syndrome is a systemic autoimmune disease characterized by dysfunction of the secretory glands. There is no effective treatment.based on the complementary properties of leflunomide and hydroxychloroquine in inhibiting the activation of key immune cells in primary Sjogren's syndrome, the lancet rheumatology published a study to evaluate the clinical efficacy and safety of leflunomide hydroxychloroquine in the treatment of primary Sjogren's syndrome.a placebo-controlled, double-blind, phase 2A randomized clinical trial was conducted at the medical center of Utrecht University in the Netherlands.all eligible patients were between 18 and 75 years old. The EULAR Sjogren's syndrome activity index (essdai) score of the European Union Against Rheumatism (EULAR) Sjogren's syndrome activity index (essdai) score was 5 or higher, and the lymphocyte focus index was 1 or higher.the study included 29 patients (28 women and 1 male) who received leflunomide 20 mg and hydroxychloroquine 400 mg (n = 21) or placebo (n = 8) daily. After 24 weeks, the essdai score was evaluated.from 0 to 24 weeks, the baseline adjusted essdai score of leflunomide hydroxychloroquine group was - 4.35 (P = 0.0078).in addition, no serious adverse events occurred in the leflunomide hydroxychloroquine group. The most common adverse reactions were gastrointestinal discomfort and moderate transient elevation of alanine aminotransferase.in conclusion, the efficacy and safety of leflunomide hydroxychloroquine in the treatment of primary Sjogren's syndrome are worth looking forward to, but further evaluation of leflunomide hydroxychloroquine combination therapy is still needed in larger clinical trials.in recent years, more and more patients with Ana positive? Antinuclear antibody (ANA), as an important biomarker of autoimmune diseases, is the most widely used and basic group of autoantibodies.at present, Ana is the general term of autoantibodies that take various components of eukaryotic cells as target antigens, mainly including: various components of deoxyribonucleoprotein (DNP), deoxyribonucleic acid (DNA), extractable nuclear antigen (ENA) and ribonucleic acid (RNA).there is increasing evidence of an increase in the prevalence of autoimmune diseases, but the results are limited by the lack of systematic data and evolving methods and definitions.a study investigated the prevalence of ANA positive in the United States over a period of 25 years in order to understand the changes in the prevalence of autoimmune diseases (AID).as an important biological marker of aid, Ana is common in patients with systemic (non organ specific) aid such as systemic lupus erythematosus, Sjogren's syndrome and systemic sclerosis (Table 1).Table 1 clinical application of ANA in this study, standard indirect immunofluorescence assay was used to determine the clinical application of ana, The prevalence of ANA was 11.0% (95% CI 9.7% - 12.6%) in 1988-1991, 11.5% (95% CI 10.3% - 12.8%) in 1999-2004 and 15.9% (95% CI 14.3% - 17.6%; P & lt; 0.0001) in 2011-2012, affecting 22 million, 27 million and 41 million people, respectively.in the study, there was a significant increase in the prevalence of ANA in adolescents aged 12-19 years, while it did not appear to be associated with weight (obesity / overweight), smoking or alcohol intake among men, the elderly (age ≥ 50 years) and non Hispanic whites.research shows that the incidence rate of ANA positive has been increasing rapidly in the United States in recent years, suggesting that other countries should also be vigilant.the potential factors of increasing ana positive prevalence may clarify the causes of aid and help to formulate preventive measures, but further exploration is still needed.reference source: [1] # seccestitle10 [3]