Immunity . . . Dong Chen/Chen Fang/Qin Chengfeng found that patients recovering from new coronary pneumonia can produce specific antibodies against the new coronavirus.

Due to the rapid increase of new cases, coronavirus disease (covid-19) in 2019 has attracted worldwide attention. The pathogen was identified as sars-cov-2.novel coronavirus pneumonia has been diagnosed in more than 3 million 230 thousand cases worldwide by April 30th (April 30th), and the death toll is 220 thousand.these figures are updated daily and are expected to increase further.however, there is limited understanding of the immune response, especially the adaptive immune response to sars-cov-2 infection.on May 3, 2020, Dong Chen of Tsinghua University, Chen Fang and Qin Chengfeng, Academy of military medicine, Academy of Military Sciences jointly published an online bulletin entitled "detection of sars-cov-2-specific human and cellular immunity in covid-19 consistent" In this study, blood was collected from patients with covid-19 who were recently virus-free and therefore discharged, and sars-cov-2-specific humoral and cellular immunity was detected in 8 newly discharged patients.two weeks after discharge, the follow-up analysis of another group of 6 patients also showed high titer of IgG antibody.it is worth noting that there is a strong correlation between the titer of neutralizing antibody and the number of virus specific T cells.in general, this study provides a basis for further analysis of protective immunity against sars-cov-2 and for understanding the pathogenesis of covid-19, especially in severe cases.it also has an impact on the development of an effective vaccine against sars-cov-2 infection.due to the rapid increase of new cases, coronavirus disease (covid-19) in 2019 has quickly attracted global attention.novel coronavirus infection is believed to be transmitted from animal, and the pathogen is identified as SARS-CoV-2.by January 2020, it is suspected that the initial infected patients were infected with the virus through human to human transmission.since January 2020, the virus has spread rapidly to most parts of China and other countries.novel coronavirus pneumonia has been diagnosed in more than 3 million 230 thousand cases worldwide by April 30th (April 30th), according to the real-time statistics published by the Johns Hopkins University. The total mortality rate is over 6%.the genome sequence of sars-cov-2 shared 96% and 79.5% identity with bat coronavirus and SARS CoV respectively.like SARS CoV and mers CoV, sars-cov-2 belongs to the β - coronavirus of the coronnaviridae family.clinically, in severe cases, most patients with covid 19 develop lymphocytopenia and pneumonia, and the plasma levels of inflammatory cytokines are higher, suggesting that the host immune system is involved in the pathogenesis.neutralization antibody titer measurement in convalescent individuals of covid-19 (picture from immunity) previously reported that patients infected with SARS CoV or mers cov had antibody response, but showed deficient expression of IFN type I and type II, indicating poor protective immune response.however, up to now, there are few studies on characterizing immune response, especially adaptive immune response to sars-cov-2 infection.studies have shown that covid-19 patients show specific antibody response to nucleocapsid protein (NP). IgM of one patient reaches the peak on the 9th day after onset, and then turns to IgG on the 2nd day.they also reported that sera from several patients inhibited the entry of sars-cov-2 into target cells, indicating its involvement in humoral immunity.however, the relationship between virus specific T lymphocytes and neutralizing antibody titer in patients with covid-19 has not been identified.the study collected blood from patients with covid-19 who were recently virus-free and therefore discharged. Sars-cov-2 specific humoral and cellular immunity was detected in 8 newly discharged patients.two weeks after discharge, the follow-up analysis of another group of 6 patients also showed high titer of IgG antibody.it is worth noting that there is a strong correlation between the titer of neutralizing antibody and the number of virus specific T cells.this study provides a basis for further analysis of protective immunity against sars-cov-2 and for understanding the pathogenesis of covid-19, especially in severe cases.it also has an impact on the development of an effective vaccine against sars-cov-2 infection.reference message: