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Treatment of gout, 7 types of situation hasten to take medication, 3 types of food to eat less! Guide time.
Time of Update: 2020-07-21
(level of evidence: medium) for those who can not achieve Su standard after xoi, uric acid excretion drugs and other interventions, but gout attacks are not frequent (< 2 times / year) and there is no subcutaneous gout stone, it is strongly recommended to continue the current ult treatment scheme instead of converting to peglotase treatment.
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Nature Plants . . . The team of Tsuda, a Japanese professor at Huazhong Agricultural University, used in situ bacterial transcription and proteomics in plants to identify pathogen proteins attacked by the immune system!
Time of Update: 2020-07-21
Professor, School of plant science and technology, State Key Laboratory of agricultural microbiology, Huazhong Agricultural University, and independent PI Kenichi Tsuda of Mapu Plant Breeding Research Institute are the corresponding authors of the paper.
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Express . . . The innovative monoantitherapy of lupus reached the clinical end of Phase 2 and significantly improved skin symptoms.
Time of Update: 2020-07-21
▎ Yao Ming Kant content team editor yesterday, Biogen at the European rheumatology Conference (EULAR 2020), announced the company's development of monoclonal antibody therapy biib059 treatment of skin lupus erythematosus (CLE) phase II clinical data.
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The Nat Comm-Channing team published the results of the new multivalent cervical cancer vaccine.
Time of Update: 2020-07-21
Persistent infection of human papillomavirus (HPV) can lead to proliferative lesions of epithelial tissues and a variety of benign and malignant tumors. more than 200 types of HPV have been identified
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Many children are "weird disease", the new crown virus is really "the culprit"?
Time of Update: 2020-07-21
data 3 in the United States, the New York City Department of Health reported in May 4, 2020 that 15 children aged 2 to 15 years showed mis-c symptoms, including persistent fever and elevated levels of inflammatory markers, as well as rashes, abdominal pain, vomiting or diarrhea; 10 of the 15 children were positive for sars-cov-2 infection.
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From the update of the guidelines, look at the therapeutic status of biologics in systemic lupus.
Time of Update: 2020-07-21
as the first and only biological agent approved for SLE treatment in the world, baileyumab can significantly control disease activity, reduce hormone dosage, reduce organ damage, reduce the risk of serious recurrence, and has good safety.
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These 20 common rheumatic syndromes, some even doctors do not know?!
Time of Update: 2020-07-21
You should not be aware of the common rheumatic syndrome.
there are many common syndromes in rheumatology department.
Xiaobian will rheumatology doctors need to be familiar with the daily work of 20 classic syndrome sorting, love to learn you quickly collect it!
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Nature Highlights . . . Antibody salivary acid modification affects allergic reactions.
Time of Update: 2020-07-21
the authors used mass spectrometry to analyze the N-glycan modification of IgE in these samples, and finally found that sialylation of allergic IgE increased specifically.
allergic reactions can be alleviated by removing sialic acid from IgE or by treating with desialylated glycoprotein.
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The immunoasive profile of leukemia predicts the benefits of drug resistance and immunotherapy.
Time of Update: 2020-07-21
By analyzing 442 samples from three groups of children and adults with acute myeloid leukemia (AML), the researchers identified a new immune category for the disease, which can predict the possibility of drug resistance and positive response to immunotherapy.
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Can't lupus patients ever have children? Management Advice says it's great to be! . . . 510 World Lupus Day - Mother's Day.
Time of Update: 2020-07-21
more than half of SLE patients will relapse or worsen during pregnancy, endangering the safety of fetus and pregnant women.
therefore, it is very important and necessary to standardize the perinatal management of SLE patients to improve the pregnancy success rate and reduce the maternal and infant mortality rate.
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Uric acid high gout, low depression? People with psoriasis arthritis are eating this way!
Time of Update: 2020-07-21
recently, a study published in Arts Research & amp; therapy showed that low serum uric acid levels were associated with the prevalence of depression in the elderly.
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New Phytol. The Chinese Agricultural University, in collaboration with the French Academy of Agricultural Sciences, has revealed a new mechanism for root knot nematodes to inhibit plant immune response.
Time of Update: 2020-07-21
Recently, Professor Jian Heng of China Agricultural University and Professor Pierre abad of Sophia Institute of agricultural biotechnology, French Academy of Agricultural Sciences, published the "root knot nematode effector mipdi1 targets a stress associated protein, SAP", To establish disease in Solanaceae and Arabidopsis "revealed the molecular mechanism of Meloidogyne incognita inhibiting plant immune response and enhancing its parasitism by secreting effector mipdi1.
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Cytokine storms: the time of immune response to new crown pneumonia or exacerbation of the disease.
Time of Update: 2020-07-21
text in their study, Du and Yuan adopted a general mathematical model called "target cell restriction model" to understand how the immune system of patients with covid-19 reacts compared with those with influenza.
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Science's new research upends cognition and is expected to solve the problem that has plagued organ transplants for more than 60 years, netizens: biology textbooks have to be changed.
Time of Update: 2020-07-21
The key point is that innate myeloid immune cells such as macrophages and monocytes can also produce antigen-specific immune memory.
in further experiments, the researchers tried to block pir-a with antibody and knock out pir-a site gene respectively, and found that without pir-1, monocytes and macrophages of mice would not produce specific immune memory for antigen.
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Yu Xiaobo/Li Yongzhe team used SARS-CoV-2 full proteomic chip to fully reveal the expression and distribution of viral antibodies in serum in patients with early neo-coronapneumonia.
Time of Update: 2020-07-21
The Proteome-wide analysis of differentially-expressed SARS-CoV-2 antibodies in in [2] was used to detect and analyze the expression and distribution of new crown virus antibodies in the serum of patients with early new coronavirus pneumonia and suspected patients (Fig. 1).
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Nature. Bohai/Hu Wei/Zhong Yi collaborated to report on the new mechanism of brain-spleen neural loop control antibody immune response.
Time of Update: 2020-07-21
through the mouse model, this study found a neural pathway from the CRH neurons in the amygdala and paraventricular nucleus to the spleen; this pathway promotes the antibody immune response induced by vaccination and regulates the immune response in response to somatic behavioral stimuli.
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Too cunning, Chinese and American scholars have confirmed that the new crown virus can use the body's immune system, open the door to invasion, enhance infection and transmission capacity.
Time of Update: 2020-07-21
novel coronavirus pneumonia, which is generally confirmed by the two studies, indicates that the new crown virus can enhance its ability of infection and transmission by inducing its receptor ACE2 expression.
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"Guidelines for primary diagnosis and treatment of gout and hyperuric acid (2019)" was published! Guide sharing.
Time of Update: 2020-07-21
Suggestions of antiuricemic drug treatment: ① for gout patients who meet the following clinical conditions, we can start drug uric acid lowering therapy (special note: we need to pay attention to the adverse reactions of uric acid reducing drugs): ➤ gouty arthritis attacks ≥ 2 times / year.
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Inflammation, fat deposition and new bone formation: the mystery of the structural progression of strong straight spina bifida.
Time of Update: 2020-07-21
several MRI studies have confirmed that during the follow-up of axspa patients, the changes of "inflammation → fat deposition → new bone formation" can be observed from MRI and X-ray examination results over time.
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EULAR heavy lupus research interpretation , biological agents to treat lupus nephritis future has come.
Time of Update: 2020-07-21
Professor Zhang Fengchun, chairman of the conference and director of the Department of internal medicine of Peking Union Medical College Hospital, introduced: "six years ago, a Northeast Asian Study of 500 patients with baileyumab also showed that the drug can reduce the double stranded DNA level and increase the complement level of lupus patients, and the symptoms of LN patients have been improved, and the hormone dose is reduced.