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Inflammation, fat deposition and new bone formation: the mystery of the structural progression of strong straight spina bifida.
Time of Update: 2020-07-21
several MRI studies have confirmed that during the follow-up of axspa patients, the changes of "inflammation → fat deposition → new bone formation" can be observed from MRI and X-ray examination results over time.
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More than 15% of rheumatic clinics are seeing this? The focus of the diagnosis and treatment once clear!
Time of Update: 2020-07-21
Professor Daniel clausw pointed out: FMS is a kind of disease caused by abnormal amplification of "volume" of central pain processing regulator.
Professor Daniel clausw pointed out that in clinical practice, many doctors ignore the screening of FMS when they are faced with chronic pain patients with certain primary diseases, resulting in patients receiving wrong treatment.
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Can't lupus patients ever have children? Management Advice says it's great to be! . . . 510 World Lupus Day - Mother's Day.
Time of Update: 2020-07-21
more than half of SLE patients will relapse or worsen during pregnancy, endangering the safety of fetus and pregnant women.
therefore, it is very important and necessary to standardize the perinatal management of SLE patients to improve the pregnancy success rate and reduce the maternal and infant mortality rate.
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Nature. Bohai/Hu Wei/Zhong Yi collaborated to report on the new mechanism of brain-spleen neural loop control antibody immune response.
Time of Update: 2020-07-21
through the mouse model, this study found a neural pathway from the CRH neurons in the amygdala and paraventricular nucleus to the spleen; this pathway promotes the antibody immune response induced by vaccination and regulates the immune response in response to somatic behavioral stimuli.
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Science Back-to-Back . . . Natural immunity or DNA vaccine immunity can provide effective memory immunity protection for rhesus monkey SARS-CoV-2 reinfection.
Time of Update: 2020-07-21
it is important that the specific antibody and cellular immune responses of sars-cov-2 were observed in all rhesus monkeys on the 35th day, and the T cell response of the high-dose group was more intense.
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Cell Reports . . . Wen Jinsheng and others reveal the protective mechanisms of dengue virus/Zika virus cross-reactive CD4 plus T cells.
Time of Update: 2020-07-21
these results indicate that dengue virus / Zika virus cross reactive CD4 + T cells can play an anti Zika virus infection role by secreting IFN - or TNF.
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Express . . . For the treatment of rare immune diseases, Roche IL-6 antibodies were treated with long-term safety data.
Time of Update: 2020-07-21
Today, Genentech, a Roche company, released long-term safety data on its IL-6 antibody satralizumab in the treatment of adult and adolescent patients with neuromyelitis optica spectrum disorder (nmosd).
"reference: [1] new long term data reinforcement safety of Genentech's satralizumab in adults and adolescents with neuromyelitis optica spectrum disorder (nmosd).
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Too cunning, Chinese and American scholars have confirmed that the new crown virus can use the body's immune system, open the door to invasion, enhance infection and transmission capacity.
Time of Update: 2020-07-21
novel coronavirus pneumonia, which is generally confirmed by the two studies, indicates that the new crown virus can enhance its ability of infection and transmission by inducing its receptor ACE2 expression.
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EULAR Express . . . Data on the efficacy and safety of Bellitum was confirmed in the population with active lupus nephritis.
Time of Update: 2020-07-21
bliss-ln: a randomized, double-blind, global, phase III study to evaluate the efficacy and safety of baileyumab for injection in patients with active lupus erythematosus.
Compared with the traditional treatment, baileyumab combined with standard treatment can significantly improve the renal response of patients with lupus nephritis, with good safety.
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Cytokine storms: the time of immune response to new crown pneumonia or exacerbation of the disease.
Time of Update: 2020-07-21
text in their study, Du and Yuan adopted a general mathematical model called "target cell restriction model" to understand how the immune system of patients with covid-19 reacts compared with those with influenza.
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EULAR heavy lupus research interpretation , biological agents to treat lupus nephritis future has come.
Time of Update: 2020-07-21
Professor Zhang Fengchun, chairman of the conference and director of the Department of internal medicine of Peking Union Medical College Hospital, introduced: "six years ago, a Northeast Asian Study of 500 patients with baileyumab also showed that the drug can reduce the double stranded DNA level and increase the complement level of lupus patients, and the symptoms of LN patients have been improved, and the hormone dose is reduced.
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Does methotrexate not increase the risk of RA lung disease? These "lung care" methods are known to know about the seULAR 2020.
Time of Update: 2020-07-21
an oral report at the 2020 EULAR annual meeting (Abstract: 0p0035) [4] included 8963 RA patients diagnosed from the discussion analytics jointman database to assess the epidemiological and clinical characteristics of rheumatoid arthritis with interstitial lung disease (ra-ild).
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Many children are "weird disease", the new crown virus is really "the culprit"?
Time of Update: 2020-07-21
data 3 in the United States, the New York City Department of Health reported in May 4, 2020 that 15 children aged 2 to 15 years showed mis-c symptoms, including persistent fever and elevated levels of inflammatory markers, as well as rashes, abdominal pain, vomiting or diarrhea; 10 of the 15 children were positive for sars-cov-2 infection.
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Express . . . Lilly IL-17A inhibitors have been approved by the FDA for the treatment of mid-axis spinal arthritis.
Time of Update: 2020-07-21
Lilly, editor of the content team of Wuxi apptec, announced today that the US FDA has approved the extended indications of taltz (ixekizumab), an IL-17A antagonist developed by the company, for the treatment of patients with active non radiologic axial spondylitis (NR axspa) with objective inflammatory symptoms.
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Science: Why dust mites cause allergies and asthma may be the lack of such immune cells in our bodies.
Time of Update: 2020-07-21
In a recent study published in the journal Science immunology, scientists from the La Jolla Institute of Immunology (LJI) provided a clue - they found a previously unknown T-cell subset that can control allergic immune responses and asthma from house dust mites and other possible allergens.
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From the update of the guidelines, look at the therapeutic status of biologics in systemic lupus.
Time of Update: 2020-07-21
as the first and only biological agent approved for SLE treatment in the world, baileyumab can significantly control disease activity, reduce hormone dosage, reduce organ damage, reduce the risk of serious recurrence, and has good safety.
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Immunity . . . Dong Chen/Chen Fang/Qin Chengfeng found that patients recovering from new coronary pneumonia can produce specific antibodies against the new coronavirus.
Time of Update: 2020-07-21
in general, this study provides a basis for further analysis of protective immunity against sars-cov-2 and for understanding the pathogenesis of covid-19, especially in severe cases.
this study provides a basis for further analysis of protective immunity against sars-cov-2 and for understanding the pathogenesis of covid-19, especially in severe cases.
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Cell Res . . . Breakthrough, Wuhan University's zhongbo team found that ubiquitin adjusts the stability of cGAS and promotes cellular antiviral response and autoimmune.
Time of Update: 2020-07-21
therefore, the findings reveal the key role of usp29 in innate antiviral response to DNA viruses and autoimmune diseases, and provide insights into the regulation of CGAs. the innate immune response to viral infection is triggered by pattern recognition receptors (PRRS), including toll like receptors (TLRs), RIG-I-like receptors and cytoplasmic DNA sensors.
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Immunity . . . The cooperation between Gao Yimeng/Li Huabing and others reveals the important role of m6A in natural immunity and hematopoietic development.
Time of Update: 2020-07-21
In higher mammals, RNA, as an intermediate carrier of genetic material, has been a research hotspot in various fields, including alternative splicing, post transcriptional processing, translation init
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White plug disease mouth ulcers, these treatment options are all brilliant! EULAR 2020.
Time of Update: 2020-07-21
at present, the most popular drug in the treatment of Behcet's disease is aprost (4-phosphodiesterase inhibitor), which has been proved to be effective in treating oral ulcer of Behcet's disease by phase 3 clinical studies (relief).
