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White plug disease mouth ulcers, these treatment options are all brilliant! EULAR 2020.
Time of Update: 2020-07-21
at present, the most popular drug in the treatment of Behcet's disease is aprost (4-phosphodiesterase inhibitor), which has been proved to be effective in treating oral ulcer of Behcet's disease by phase 3 clinical studies (relief).
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B-cell critical pathways open a new era in lupus targeted therapy.
Time of Update: 2020-07-21
baileyumab can be used in the treatment of systemic lupus erythematosus, which can control disease activity, reduce hormone dosage and recurrence risk, reduce organ damage, and its safety is similar to placebo.
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Express . . . Novartis heavy IL-17A inhibitors have won the fourth FDA indication to treat mid-axis spinal arthritis.
Time of Update: 2020-07-21
▎ recently, Novartis announced that the US FDA has approved the expansion of cosentyx (secukinumab), a heavyweight IL-17A inhibitor, for the treatment of active non radiologic axial spondylitis (NR axspa).
"References: [1] Novartis cosentyx Receives FDA approval for new indication to treat active non-radiological axial spondyloarthritis.
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"Promotions" in clinical guidelines recommended by Treasury
Time of Update: 2020-07-21
in 2016, in the management guidelines for axial spondyloarthritis (axspa) published by ASAS / EULAR [1], patients with as who are still at disease activity after NSAIDs treatment and patients who fail TNF inhibitor (tnfi) treatment can choose IL-17 inhibitors for treatment (A-level Recommendation / evidence level 1b, figure 1).
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Yu Xiaobo/Li Yongzhe team used SARS-CoV-2 full proteomic chip to fully reveal the expression and distribution of viral antibodies in serum in patients with early neo-coronapneumonia.
Time of Update: 2020-07-21
The Proteome-wide analysis of differentially-expressed SARS-CoV-2 antibodies in in [2] was used to detect and analyze the expression and distribution of new crown virus antibodies in the serum of patients with early new coronavirus pneumonia and suspected patients (Fig. 1).
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Nature. The mechanism by which autophagy promotes immune escape for pancreatic cancer.
Time of Update: 2020-07-21
Kimmelman of New York University School of medicine in nature In PDAC, we report that nbr1, an autophagic cargo receptor protein, targets and selects MHC-I molecules on the cell surface and downregulates MHC-I through autophagy dependent lysosomal degradation pathway.
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Express . . . The innovative monoantitherapy of lupus reached the clinical end of Phase 2 and significantly improved skin symptoms.
Time of Update: 2020-07-21
▎ Yao Ming Kant content team editor yesterday, Biogen at the European rheumatology Conference (EULAR 2020), announced the company's development of monoclonal antibody therapy biib059 treatment of skin lupus erythematosus (CLE) phase II clinical data.
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Science's new research upends cognition and is expected to solve the problem that has plagued organ transplants for more than 60 years, netizens: biology textbooks have to be changed.
Time of Update: 2020-07-21
The key point is that innate myeloid immune cells such as macrophages and monocytes can also produce antigen-specific immune memory.
in further experiments, the researchers tried to block pir-a with antibody and knock out pir-a site gene respectively, and found that without pir-1, monocytes and macrophages of mice would not produce specific immune memory for antigen.
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Eradicating Helicobacter pylori, actually has this effect on the white plug disease?
Time of Update: 2020-07-21
In this study, the researchers comprehensively analyzed the correlation between HP and BS through meta-analysis, and discussed the impact of HP eradication on the symptoms of BS, that is, the HP infection rate of BS patients was higher than that of healthy people.
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Immunity . . . The Tsinghua Dongchen team reported on the body fluids and cellular immune responses of patients recovering from new crown pneumonia.
Time of Update: 2020-07-21
using the purified sars-cov-2 N protein (nucleocapsid protein), major protease and s-rbd (spike glycoprotein receptor binding region) expressed and purified in vitro, the researchers detected specific IgM and IgG antibodies against these proteins in the sera of convalescent patients.
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Nature. Chen Huan and others revealed the mechanism of action of the intestinal lymphatic tissue birth center in mice under physiological conditions.
Time of Update: 2020-07-21
in this paper, we found that a series of antibodies appeared in many mice, which were called public antibodies It is the first time to reveal the role of B lymphocyte clone proliferation, B cell receptor specific screening and affinity maturation in the innate germinal center of the small intestine.
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Lu Yuanqiang, Zhejiang University, etc.: Lei Gongto's application of immune-mediated inflammatory diseases: research progress and prospects.
Time of Update: 2020-07-21
because Tripterygium wilfordii has significant curative effect on autoimmune diseases and has no side effects of hormones, it has attracted the attention of researchers at home and abroad in recent years, and a large number of studies have begun to explore the potential mechanism of anti-inflammatory and immunosuppression.
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Take methotrexate, folic acid to make up so! . . . you "drugs" know.
Time of Update: 2020-07-21
Don't want to miss Jiemei's push? Poke the blue word "medical rheumatism and nephropathy channel" to pay attention to us, and click the "··" menu in the upper right corner, and select "set as star" to
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Organ transplantation in the last 60 years of difficulties ushered in important progress! The latest Science finds new immune mechanisms to prevent chronic rejection.
Time of Update: 2020-07-21
experimental results in mice showed that the survival time of transplanted organs such as kidney and heart was prolonged several times by treating immune cells based on this finding.
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The Nutrition and Health Institute has discovered a new mechanism for TRIM24 in antiviral immunity.
Time of Update: 2020-07-21
On April 23, the international academic journal Journal of empirical medicine published online the research paper "trim24 facilities anti infection through mediating k63 linked traf3 ubiquitation" by Xiao Yichuan, Key Laboratory of tumor and microenvironment, Shanghai Institute of nutrition and health, Chinese Academy of Sciences.
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Cell . . . The latest and most comprehensive, Zhou Jianmin/ Zhang Yuelin system inventory plant immune perception and signal overview (worth collecting)
Time of Update: 2020-07-21
in addition, the review highlights recent breakthroughs in biosynthesis and perception of the major defense hormone salicylic acid (SA), which plays a key role in enhancing PRR and NLR mediated signal transduction.
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Latest! 6 general rules , 12 recommendations, psoriasis arthritis diagnosis and treatment guidelines a piece of knowledge.
Time of Update: 2020-07-21
10 patients with active axial arthritis who have a good response to NSAIDs should be considered for treatment with bdmads (TNF inhibitors are preferred according to current clinical practice), and IL-17 inhibitors may be preferred (Revised) when skin involvement is involved.
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Nature: Super-magical new immune mechanism! Scientists have discovered for the first time that ordinary cells release exosomes as bait to trap and neutralise the lethal toxin seditoids released by superbugs.
Time of Update: 2020-07-21
(source: med.nyu.edu ）Based on previous studies, Cadwell and Torres have known that the pore forming toxin secreted by bacteria will bind with ADAM10 on the cell surface, resulting in cell membrane perforation [5].
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Science reveals new details about human immunity: protein "bomb" of killer T cells
Time of Update: 2020-07-21
Recently, in a new study published in science, research teams from Oxford University and University of Toulouse in France have revealed more details of how killer T cells attack "foreign enemies": they use protein "bombs" loaded with lethal chemicals to bomb target cells.
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Nat Comm . . . The ichitian team proposed a new strategy for treating autoimmune diseases.
Time of Update: 2020-07-21
for such patients, one possible therapy is to use gene editing to repair gene mutations in Treg in situ in patients, so as to restore Treg function, reverse inflammation and treat diseases.
