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Treat lupus nephritis and get to know eULAR's latest recommendations!
Time of Update: 2020-07-21
for type III and type IV (± V) lupus nephritis, glucocorticoids combined with oral mycophenolate mofetil (MMF, 2-3g / day) or intravenous low-dose cyclophosphamide (500mg every 2 weeks, 6 times) is still recommended as the first-line treatment because of the most abundant evidence.
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Plant Com reviews a variety of disease-causing ways of fungal and intracellular-effect proteins.
Time of Update: 2020-07-21
Professor Paul birch of Dundee University / James Hatton Institute published the title "all roads lead to feasibility: the many modes of action of fungal and oomycete intracellular" in plant communications In this review, we summarized and discussed the research progress of intracellular effector proteins and their target interactions in oomycetes and fungi, and proposed the important research directions in the future.
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Take methotrexate, folic acid to make up so! . . . you "drugs" know.
Time of Update: 2020-07-21
Don't want to miss Jiemei's push? Poke the blue word "medical rheumatism and nephropathy channel" to pay attention to us, and click the "··" menu in the upper right corner, and select "set as star" to
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Nat Comm . . . The ichitian team proposed a new strategy for treating autoimmune diseases.
Time of Update: 2020-07-21
for such patients, one possible therapy is to use gene editing to repair gene mutations in Treg in situ in patients, so as to restore Treg function, reverse inflammation and treat diseases.
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CHOM . . . Wu Xueling's team selected the broad-spectrum neutralizing antibodies converted into IgG and IgA using the HIV surface membrane proteins shown by VSV.
Time of Update: 2020-07-21
Finally, the team analyzed the epitope recognition of the two broad-spectrum neutralizing antibodies on the surface protein of the virus, and found that both of them recognized new epitope.
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Systemic sclerosis-related interstitial pulmonary disease, the first treatment drug approved in China!
Time of Update: 2020-07-21
The approval of nidanib marks that patients with SSc ILD are out of the dilemma of no medicine to treat, which is of milestone significance for the treatment of the disease. on June 8, 2020, bringer I
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Clinical trial information for patients with moderate and severe rheumatoid arthritis (methotrexate treatment).
Time of Update: 2020-07-21
▎ the editor's finger is purple (photo: Wikimedia Commons, author: waltfletcher / CC) Background information we are conducting a multicenter, randomized, double-blind, parallel, positive controlled phase III clinical trial to evaluate the safety and efficacy of lzm008 injection and tuozhumab injection (yamero) in patients with moderate to severe active rheumatoid arthritis with poor response to methotrexate.
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Cell . . . The latest and most comprehensive, Zhou Jianmin/ Zhang Yuelin system inventory plant immune perception and signal overview (worth collecting)
Time of Update: 2020-07-21
in addition, the review highlights recent breakthroughs in biosynthesis and perception of the major defense hormone salicylic acid (SA), which plays a key role in enhancing PRR and NLR mediated signal transduction.
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Victory over Adamu Single Resistance, again over Abassup, Abbvie continued to build on.
Time of Update: 2020-07-21
select PSA 1 is a multicenter, randomized, double-blind, parallel group, active and placebo-controlled clinical phase 3 study to evaluate the safety and efficacy of rinvoq?
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Nature. Chen Huan and others revealed the mechanism of action of the intestinal lymphatic tissue birth center in mice under physiological conditions.
Time of Update: 2020-07-21
in this paper, we found that a series of antibodies appeared in many mice, which were called public antibodies It is the first time to reveal the role of B lymphocyte clone proliferation, B cell receptor specific screening and affinity maturation in the innate germinal center of the small intestine.
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Latest! 6 general rules , 12 recommendations, psoriasis arthritis diagnosis and treatment guidelines a piece of knowledge.
Time of Update: 2020-07-21
10 patients with active axial arthritis who have a good response to NSAIDs should be considered for treatment with bdmads (TNF inhibitors are preferred according to current clinical practice), and IL-17 inhibitors may be preferred (Revised) when skin involvement is involved.
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Science heavyweight: The immune textbook has to be changed again! Scientists have confirmed for the first time that myelin-like innate immune cells, such as macrophages, can even form antigen-specific immune memory scientific discoveries.
Time of Update: 2020-07-21
recently, a joint research team composed of researchers from the University of Pittsburgh and Cornell University found that congenital myeloid immune cells, such as macrophages and monocytes, can also form antigen-specific immune memory, and stimulate a stronger immune response after meeting the specific antigen next time [1].
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CHOM . . . Huang, etc., reveals multiple protective mechanisms in the bodies of Marburg virus survivors.
Time of Update: 2020-07-21
in this study, the researchers found that the non neutralizing antibody mr228 alone could completely protect mice in the infection experiment of mice, indicating that antibody neutralizing virus was not the only factor to protect the survival of patients.
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Good news for recovered patients: To stop the new coronavirus, scientists have found that our immune system has many ways.
Time of Update: 2020-07-21
in two research papers recently published in the top academic journals Science and cell, scientists have found a variety of neutralizing antibodies specific to new coronavirus and strong anti-virus immune response in the immune system of convalescent patients.
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The "gatedog" of small glial cells in the olfactory ball protects the brain from infection.
Time of Update: 2020-07-21
although the location of nasal neurons and their exposure to the external environment make them easy targets for airborne viral infections, viral respiratory infections rarely spread from the olfactory bulb to other parts of the brain that could cause fatal encephalitis.
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Science reveals new details about human immunity: protein "bomb" of killer T cells
Time of Update: 2020-07-21
Recently, in a new study published in science, research teams from Oxford University and University of Toulouse in France have revealed more details of how killer T cells attack "foreign enemies": they use protein "bombs" loaded with lethal chemicals to bomb target cells.
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Gout also has a "fake"? 6 joint diseases to be identified! Experts are playing fakes like this...
Time of Update: 2020-07-21
Editor's note: on April 20, the theme activity of "fighting gout, we are in action" jointly launched by "rheumatism and nephropathy channel of medical circles" and Clinical Immunology Department of Xijing Hospital of Air Force Military Medical University is still continuing.
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Gout only pain "foot", you are too naive! This patient has hand pain, abdominal pain, skin pain...
Time of Update: 2020-07-21
2015, joint swelling and pain aggravated, multiple subcutaneous nodules in limbs, and repeated skin ulceration of feet; blood uric acid of 700umol / l was checked to diagnose "gout", and irregular diagnosis and treatment were carried out.
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Nearly 40,000 people data: Not just gout, low or elevated uric acid are associated with a risk of death.
Time of Update: 2020-07-21
According to a new study presented by the Massachusetts General Hospital team of Harvard Medical School at the European Union against Rheumatology (EULAR) online scientific conference, data analysis of 40000 people shows that urinary acid levels may also affect the risk of death.
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Treating cytomegalocyte arteritis, these dynamics and progressions to understand! EULAR 2020.
Time of Update: 2020-07-21
First of all, from the Department of Rheumatology, Massachusetts General Hospital John.Stone The professor introduced the results of giacta study on TCZ treatment of GCA in the following two years, focusing on the recurrence of the disease.