Nearly 40,000 people data: Not just gout, low or elevated uric acid are associated with a risk of death.

▎ high uric acid levels are closely related to the well-known onset of gout. According to a new study presented by the Massachusetts General Hospital team of Harvard Medical School at the European Union against Rheumatology (EULAR) online scientific conference, data analysis of 40000 people shows that urinary acid levels may also affect the risk of death.screenshot source: EULAR this is a large cross-sectional study with data from the national health and Nutrition Survey (NHANES), which is a representative sample of the U.S. population. The research team focused on the population in which the uric acid data were obtained.of the 19954 male subjects with a median follow-up of 13.7 years, a total of 5714 deaths were recorded.at baseline, the proportion of hypertension patients with higher serum uric acid level was also higher; while the population with the lowest serum uric acid level was more likely to suffer from diabetes; in addition, with the increase of serum uric acid level, glomerular filtration rate (EGFR) decreased (indicating worse renal function), and total cholesterol increased.after further adjustment for age, weight, education level, lifestyle and comorbidities, statistical analysis showed that there was a U-shaped relationship between serum uric acid level and mortality.in other words, high or low serum uric acid levels in men may pose a risk.(Note: in general, hyperuricemia is defined as uric acid level > 7 mg / dl [420 μ mol / l].) compared with men with serum uric acid level of 5-6 mg / dl (300-360 μ mol / L), men with serum uric acid level > 8 mg / dl (480 μ mol / L) had a 52% increased risk of all-cause death; men with uric acid level < 4 mg / dl (240 μ mol / L) also had a 33% increased risk of all-cause death.further analysis of specific causes of death showed that the risk of death associated with diabetes increased by 229% when serum uric acid level was lower than 4 mg / dl; cardiovascular death risk was increased by 22% when serum uric acid level was higher than 8 mg / DL, and the risk of death related to chronic lower respiratory disease nearly doubled by 91%.one of the authors of the study, Dr. Kristin d'silva of Massachusetts General Hospital, added: "in men with low uric acid levels, the increase in mortality is mainly caused by diabetes, which may be due to polyuria caused by hyperglycemia."image source: pixabay, however, the trend of female data from the NHANES cohort was not entirely consistent.the median follow-up time of 21853 women was 14.6 years, during which 4901 deaths occurred.at the time of joining the study, people with higher serum uric acid levels were older, had higher body mass index, had more common hypertension, diabetes and elevated total cholesterol, and had a more significant decrease in EGFR.women's risk is mainly manifested in high uric acid level, while low uric acid level has no significant impact.compared with serum uric acid level of 5-6 mg / dl, women with serum uric acid level > 7 mg / dl had a 45% increased risk of all-cause death and 66% higher risk of diabetes related death.however, the team also noted that previous studies in Asian populations have shown that low serum uric acid levels lead to higher mortality in both men and women.Dr. Kristin d'silva believes that "the association between uric acid levels and the risk of death may vary among ethnic groups. "interestingly, the men and women with the highest serum uric acid levels in this study had a 77% and 45% lower risk of Alzheimer's disease-related death. Dr. Kristin d'silva further pointed out that "uric acid has antioxidant properties, and serum uric acid is negatively correlated with the risk of Alzheimer's disease and Parkinson's disease. therefore, the latest EULAR gout management recommendations do not maintain serum uric acid below 3 mg / dl (180 μ mol / L) for a long time. "in addition, we still need to further study to determine the causal mechanism behind these associations. references (slide up and down) [1] d'silva K, et al., (2020). Sex specific U-shaped relationship between two series ture and Modernity in the United States general population. EULAR 2020, abstract op0015. [2] for men, both low and high urea risk. Retrieved June 8, 2020, Note: the purpose of this article is to introduce the progress of medical and health research, not to recommend treatment options. if you need guidance on treatment plan, please go to a regular hospital.